Each week, PRF editors highlight a few papers of particular interest. This list shows current and past Editors' Picks. Take a look, choose your favorites, and make a comment or recommend them to your colleagues.
Glauser DA, Chen WC, Agin R, Macinnis BL, Hellman AB, Garrity PA, Tan M-W, Goodman MB
Genetics. 2011 May; 188(1):91-103. Epub 2011 Mar 02.
By studying wild isolates and mutants of C. elegans, Glauser et al. provide evidence that the threshold for heat avoidance in worms is genetically set and regulated by neuropeptide- and TRPV-dependent signaling pathways.
Hildebrand ME, Smith PL, Bladen C, Eduljee C, Xie JY, Chen L, Fee-Maki M, Doering CJ, Mezeyova J, Zhu Y, Belardetti F, Pajouhesh H, Parker D, Arneric SP, Parmar M, Porreca F, Tringham E, Zamponi GW, Snutch TP
Pain. 2011 Apr; 152(4):833-43. Epub 2011 Feb 23.
A new compound stabilizes voltage-gated sodium and calcium channels in their slow-inactivated state to reduce the excitability of nociceptors and dorsal horn neurons, resulting in a reduction in neuropathic pain signaling.
Rhudy JL, Martin SL, Terry EL, France CR, Bartley EJ, Delventura JL, Kerr KL
Pain. 2011 Apr; 152(4):794-801.
Does temporal summation of pain ratings reflect temporal summation of nociceptive processes? Rhudy et al. show that catastrophizing is associated with temporal summation based on pain ratings but not spinal nociceptive processes.
Pain. 2011 Mar; 152(3 Suppl):S1. Epub 2010 Dec 07.
From the journal PAIN and the IASP, a special compilation of reviews from 13 leaders in the field, reflecting the plenary lecture topics at the recent World Congress on Pain in Montreal. For a complete list of articles, view the comment.