Pain Research Forum

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  • Investigators need a solid grounding in cellular and molecular mechanisms of pain to make effective translation possible, says PRF science advisor Ru-Rong Ji. Read the full interview.

  • Insulin-like growth factor promotes pain via a novel signaling pathway that modulates T-type calcium channels to boost neuron excitability. Read more...

  • Rocky Mountain Highlights: Pain and the Brain

    Exclusive coverage of Keystone Symposium on The Brain: Adaptation and Maladaptation in Chronic Pain. See Part 1, Part 2, and Part 3.


  • Registration is now open for a November 24 webinar with Nathaniel Katz. For more information see here.

  • PRF science advisor Howard Fields is working to understand addiction and the best ways to prevent and treat it. Read the full interview here.


Nov 12 2014
Interactions of tumor cells and nerves are complex and reciprocal, according to Brian Schmidt at World Congress on Pain
blog Conferences
Nov 05 2014
Part 3 of coverage of the Keystone Symposium on The Brain: Adaptation and Maladaptation in Chronic Pain
news Conferences | Research
Nov 04 2014
Part 2 of coverage of the Keystone Symposium on The Brain: Adaptation and Maladaptation in Chronic Pain
news Conferences | Research
Nov 03 2014
Coverage of the Keystone Symposium on The Brain: Adaptation and Maladaptation in Chronic Pain
news Conferences | Research

Papers of the Week

Community & Resource Updates

24 Nov 2014 to 28 Nov 2014
Cape Town, South Africa
The European Pain Federation EFIC in cooperation with Grünenthal
Deadline for applications:
31 Dec 2014
Minneapolis, Minnesota, US

Community Updates Lower block


Nov 18 2014

This is the third in a series of Forum interviews with PRF’s...

Nov 17 2014

Editors' Note: Tim Meeker, a PhD student working with Joel Greenspan and David Seminowicz at the University of Maryland,...

journal club

Recent Comments

Nov 21 2014
I really like this new paper from Lavanya Moparthi and colleagues that...
Nov 03 2014
The study by Zhang et al. is exciting to me for two reasons. One is that...
Nov 03 2014
I read the paper by Dr. Zhang et al. with great interest. They showed IGF-...
Oct 30 2014
There has been considerable recent interest in possible autoimmune...
Oct 09 2014
“Why are opioids not very effective in neuropathic pain, or why do...
Sep 16 2014
Ed Perl was at the International Union of Physiological Sciences (IUPS)...
Sep 02 2014
Ed Perl was a major figure in the development of the modern science of...
Aug 15 2014
This comment was coauthored by Christine Dobek, Queen’s University,...
Aug 14 2014
Viviana Gradinaru’s laboratory has published a fascinating article...
Aug 13 2014
In a recent article published in the Journal of Pain, Dobek and colleagues...
Aug 12 2014
Paracetamol (acetaminophen), discovered in the 1950s, is prescribed for a...
Aug 11 2014
For those of us who have been engaged in studies of primary afferents and...
Aug 07 2014
The study by van Gorp and colleagues addressed an important issue related...
Aug 06 2014
The news of Dr. Edward Perl’s death struck me like the loss of an...
Aug 06 2014
I am saddened to learn of Ed Perl's death.  Alan Light has composed an...
Aug 06 2014
This is an important paper, since fulranumab was the second most...
Aug 04 2014
Thanks for the webinar. I  run a Chronic Fatigue Syndrome and Fibromyalgia...
Jul 17 2014
This comment was co-authored by Jonathan Lee, University of Birmingham,...
Jul 16 2014
By: Ted Price
This paper marks a very interesting advance for the field and furthers the...
Jul 14 2014
The hypothesis that has not been considered in this discussion is one...
Jul 07 2014
A paper describing this work has now been published: Connexin-43 induces...
Jul 02 2014
A blogger for Health Rising, a forum dedicated to fibromyalgia and chronic...
May 30 2014
Some researchers have expressed concern that a new NIH mandate calling for...
May 21 2014
By: Min Zhuo
This comment was co-authored by Tao Chen, University of Toronto, Canada...
May 16 2014
SCN11A (and its protein product Nav1.9) now has its due recognition...

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Research Resources

Information for the new researcher or veteran in the field, Pain 101 is our growing collection of topical articles on important issues in pain research. Check out our articles on modeling pain in lower organisms, the role of glia in chronic pain, and transcranial magnetic stimulation. Our Pain Genes Resource will have the most up-to-date information on the genetics of pain sensitivity, risk of chronic pain and response to analgesics, presented in a format that makes it easy to keep current. We're in the process of pulling together data on the first  53 genes—you can help this resource grow by submitting new genes and studies. Stay tuned for more resources to come, including our Drug Pipeline database.