Transient Receptor Potential Ankyrin 1 (TRPA1) Methylation and Chronic Pain: A Systematic Review.

Source: Genes (Basel) 2023 Feb 04; 14(2). doi: 10.3390/genes14020411Authors: Celsi F, Peri F, Cavasin J, Zupin L, Cozzi G, Barbi E, Crovella S

Chronic pain represents a major global health issue in terms of psycho-physiological, therapeutic, and economic burden, not limited to adults but also to the pediatric age. Despite its great impact, its molecular mechanisms have still not been completely unraveled. Focusing on the impact of epigenetics in the pain complex trait, we assessed the association between chronic pain and the methylation pattern of TRPA1, a key gene related to pain sensitivity.

Pubmed ID: https://pubmed.ncbi.nlm.nih.gov/36833338/