Transient depletion of macrophages alters local inflammatory response at the site of disc herniation in a transgenic mouse model.
PAPERS | February 4-10, 2023 | |
Source: Osteoarthritis Cartilage 2023 Feb 06; . doi: 10.1016/j.joca.2023.01.574Authors: Xiao L, Matharoo J, Chi J, Ma J, Chen M, Manley B, Xu P, Shi W, Felder RA, Sung SJ, Jin L, Li X
Macrophages are abundantly detected at sites of disc herniation, however, their function in the disease progression is unclear. We aim to investigate the functions of macrophages in acute disc herniation using a macrophage Fas-induced apoptosis (MaFIA) transgenic mouse strain.
Pubmed ID: https://pubmed.ncbi.nlm.nih.gov/36754251/