The Role of IL-6 and TMEM100 in Lumbar Discogenic Pain and the Mechanism of the Glycine-Serine-Threonine Metabolic Axis: A Metabolomic and Molecular Biology Study.

Source: J Pain Res 2023; 16. doi: 10.2147/JPR.S400871Authors: Guo Z, Ma Y, Wang Y, Xiang H, Yang SY, Guo Z, Wang R, Chen W, Xing D, Chen B, Tao H, Wu X

It is well established that discogenic low back pain (DLBP) is often caused by the inflammatory response during intervertebral disc degeneration (IDD). However, it remains unclear how inflammatory mediators such as Interleukin-6 (IL-6) are involved in discogenic pain caused by degeneration and intervertebral disc (IVD) metabolism. The purpose of this study is to study the relationship between IL-6 and Transmembrane protein 100 (TMEM100), and to analyze the different metabolites and metabolic pathways in various rat intervertebral discs by metabonomics.

Pubmed ID: https://pubmed.ncbi.nlm.nih.gov/36815126/