PACAP inhibition alleviates neuropathic pain by modulating Nav1.7 through the MAPK/ERK signaling pathway in a rat model of chronic constriction injury.

Source: Neuropeptides 2023 Feb 15; 99. doi: 10.1016/j.npep.2023.102327Authors: Liu M, He F, Shao M, Li T, Wang L, Wang Y, Xu W

Trigeminal neuralgia is a common chronic maxillofacial neuropathic pain disorder, and voltage-gated sodium channels (VSGCs) are likely involved in its pathology. Prior studies report that pituitary adenylate cyclase-activating polypeptide (PACAP), a neuropeptide highly expressed in the trigeminal ganglion, may contribute to dorsal root ganglion neuron excitability by modulating the Nav1.7.

Pubmed ID: https://pubmed.ncbi.nlm.nih.gov/36842389/