The Preemptive Analgesic Effect of Capsaicin Involves Attenuations of Epidermal Keratinocytes Proliferation and Expression of Pro-Inflammatory Mediators After Plantar Incision in Rats.

PAPERS | January 21 - February 3, 2023 | |

Source: J Pain Res 2023; 16. doi: 10.2147/JPR.S395065Authors: Guo R, Qiu H, Li H, Ma D, Guan Y, Wang Y

Subcutaneous infiltration of capsaicin, which initially activates transient receptor potential vanilloid 1 (TRPV1) receptors, can subsequently desensitize TRPV1-expressing nociceptors and induce analgesia in different pain models. Yet, whether the modulation of keratinocytes may also contribute to the analgesic action of capsaicin treatment remains unclear. In a rat model of postoperative pain, we tested the hypothesis that subcutaneous injection of capsaicin inhibited the proliferation of epidermal keratinocytes and their expression of pronociceptive inflammatory mediators after plantar incision.

Pubmed ID: http://www.ncbi.nlm.nih.gov/pubmed/36704542?dopt=Abstract