Capsaicin receptor TRPV1 maintains quiescence of hepatic stellate cells in the liver via recruitment of SARM1.

Source: J Hepatol 2023 Jan 17; . doi: 10.1016/j.jhep.2022.12.031Authors: Tao L, Yang G, Sun T, Tao J, Zhu C, Yu H, Cheng Y, Yang Z, Xu M, Jiang Y, Zhang W, Wang Z, Ma W, Wu L, Xue D, Wang D, Yang W, Zhao Y, Horsefield S, Kobe B, et al.

Capsaicin receptor, also known as transient receptor potential vanilloid 1 (TRPV1), is involved in pain physiology and neurogenic inflammation. Herein, we discovered the presence of TRPV1 in hepatic stellate cells (HSCs) and aimed to delineate its function in this cell type and liver fibrosis.

Pubmed ID: http://www.ncbi.nlm.nih.gov/pubmed/36669703?dopt=Abstract