Eplerenone modulates the inflammatory response in monosodium iodoacetate-induced knee osteoarthritis in rats: Involvement of RANKL/OPG axis.

Source: Life Sci 2023 Jan 18; . doi: 10.1016/j.lfs.2023.121405Authors: Mostafa RE, Salama AAA

Osteoarthritis (OA) is a multifactorial degenerative disease marked by the progressive deterioration of articular cartilage with inflammation of the synovium. OA’s main symptoms include pain and function loss. Monosodium Iodoacetate (MIA) experimental model is widely-used for OS induction since it produces symptoms comparable to those occurring in humans.

Pubmed ID: http://www.ncbi.nlm.nih.gov/pubmed/36681186?dopt=Abstract