Inhibition of TRPM8 by the urinary tract analgesic drug phenazopyridine.

Source: Eur J Pharmacol 2023 Jan 16; . doi: 10.1016/j.ejphar.2023.175512Authors: Luyts N, Daniluk J, Freitas A, Bazeli B, Janssens A, Mulier M, Everaerts W, Voets T

and purpose: Phenazopyridine (PAP) is an over-the-counter drug widely used to provide symptomatic relief of bladder pain in conditions such as cystitis or bladder pain syndrome (BPS). Whereas the analgesic effect of PAP has been attributed to a local effect on the mucosa of the lower urinary tract (LUT), the molecular targets of PAP remain unknown. We investigated the effect of PAP on pain-related Transient Receptor Potential (TRP) channels expressed in sensory neurons that innervate the bladder wall.

Pubmed ID: http://www.ncbi.nlm.nih.gov/pubmed/36657655?dopt=Abstract