Human-specific duplicate CHRFAM7A gene is associated with more severe osteoarthritis and amplifies pain behaviours.
PAPERS | January 7-13, 2023 | |
Source: Ann Rheum Dis 2023 Jan 10; . doi: 10.1136/ard-2022-223470Authors: Courties A, Olmer M, Myers K, Ordoukhanian P, Head SR, Natarajan P, Berenbaum F, Sellam J, Lotz MK
CHRFAM7A is a uniquely human fusion gene that functions as a dominant negative regulator of alpha 7 acetylcholine nicotinic receptor (α7nAChR) in vitro. This study determined the impact of CHRFAM7A on α7nAChR agonist responses, osteoarthritis (OA) severity and pain behaviours and investigated mechanisms.
Pubmed ID: http://www.ncbi.nlm.nih.gov/pubmed/36627169?dopt=Abstract