The Biology of Pain – Through the Rheumatology Lens.

Source: Arthritis Rheumatol 2023 Jan 04; . doi: 10.1002/art.42429Authors: Sunzini F, Schrepf A, Clauw DJ, Basu N

Chronic pain is a major socio-economic burden globally. The most frequent origin for chronic pain is musculoskeletal. In inflammatory musculoskeletal diseases, such as rheumatoid arthritis (RA), chronic pain is a primary determinant of deleterious quality of life. The pivotal role of peripheral inflammation in the initiation and perpetuation of nociceptive pain is well-established among these patients. However, the persistence of pain, even after the apparent resolution of peripheral inflammation, alludes to the co-existence of different pain states. Recent advances in neurobiological knowledge have highlighted the importance of nociplastic pain mechanisms. In this review we aim to explore the biology of pain with a particular focus on nociplastic pain and RA. This article is protected by copyright. All rights reserved.

Pubmed ID: http://www.ncbi.nlm.nih.gov/pubmed/36599071?dopt=Abstract