Primary somatosensory cortex and periaqueductal gray functional connectivity as a marker of the dysfunction of the descending pain modulatory system in fibromyalgia.

Source: Korean J Pain 2023 Jan 01; 36(1). doi: 10.3344/kjp.22225Authors: Soldatelli M, de Franco Á O, Picon F, Duarte J Á, Scherer R, Bandeira J, Zortea M, da Torres I L S, Fregni F, Caumo W

Resting-state functional connectivity (rs-FC) may aid in understanding the link between pain-modulating brain regions and the descending pain modulatory system (DPMS) in fibromyalgia (FM). This study investigated whether the differences in rs-FC of the primary somatosensory cortex in responders and non-responders to the conditioned pain modulation test (CPM-test) are related to pain, sleep quality, central sensitization, and the impact of FM on quality of life.

Pubmed ID: http://www.ncbi.nlm.nih.gov/pubmed/36581601?dopt=Abstract