September 9-15, 2023
Showing 1-25 of 114.
Halide Perovskites-based Diffusive Memristors for Artificial Mechano-Nociceptive System.
Source: Adv Mater 2023 Sep 14;. doi: 10.1002/adma.202307334 Authors: Im IH, Baek JH, Kim SJ, Kim J, Park SH, Kim JY, Yang JJ, Jang HW Numerous efforts for emulating organ systems comprised of multiple functional units have driven substantial advancements in bio-realistic electronics and systems….
Human OPRM1 and murine Oprm1 promoter driven viral constructs for genetic access to μ-opioidergic cell types.
Source: Nat Commun 2023 Sep 13; 14(1). doi: 10.1038/s41467-023-41407-2 Authors: Salimando GJ, Tremblay S, Kimmey BA, Li J, Rogers SA, Wojick JA, McCall NM, Wooldridge LM, Rodrigues A, Borner T, Gardiner KL, Jayakar SS, Singeç I, Woolf CJ, Hayes MR, De Jonghe BC, Bennett FC,…
Galcanezumab Efficacy Through the Dosing Interval in Japanese Patients with Episodic Migraine: Post Hoc Analysis of a Phase 2 Randomized Trial.
Source: Neurol Ther 2023 Sep 12; . doi: 10.1007/s40120-023-00534-0Authors: Shibata M, Nihira A, Tanji Y, Ozeki A, Imagawa H, Komori M The efficacy and safety of galcanezumab as a preventive treatment in Japanese patients with episodic migraine was demonstrated in a phase 2, randomized, placebo-controlled…
Placebo analgesia and nocebo hyperalgesia in patients with Alzheimer disease and healthy participants.
Source: Pain 2023 Sep 08; . doi: 10.1097/j.pain.0000000000003035Authors: Matthiesen ST, Sieg M, Andersen SS, Amanzio M, Finnerup NB, Jensen TS, Gottrup H, Vase L The role of placebo analgesia and nocebo hyperalgesia in patients with Alzheimer disease (AD) is largely unknown, with only few studies…
M2 macrophage polarization: a potential target in pain relief.
Source: Front Immunol 2023; 14. doi: 10.3389/fimmu.2023.1243149Authors: Zhao W, Ma L, Deng D, Zhang T, Han L, Xu F, Huang S, Ding Y, Chen X Pain imposes a significant urden on patients, affecting them physically, psychologically, and economically. Despite numerous studies on the pathogenesis of…
Perspective on salutogenic approaches to persistent pain with a focus on mindfulness interventions.
Source: Front Pain Res (Lausanne) 2023; 4. doi: 10.3389/fpain.2023.1188758Authors: Paley CA, Johnson MI In this article, we provide a unique perspective on the use of mindfulness interventions in a whole health framework embedded within the theory of salutogenesis and the concept of painogenic environments. We…
Potential Mechanism of Fatigue Induction and Its Management by JAK Inhibitors in Inflammatory Rheumatic Diseases.
Source: J Inflamm Res 2023; 16. doi: 10.2147/JIR.S414739Authors: Felis-Giemza A, Massalska M, Roszkowski L, Romanowska-Próchnicka K, Ciechomska M It is well known that fatigue is a highly disabling symptom commonly observed in inflammatory rheumatic diseases (IRDs). Fatigue is strongly associated with a poor quality of…
PACAP38-related modulation of the cranial parasympathetic projection: a novel mechanism and therapeutic target in severe primary headache.
Source: Br J Pharmacol 2023 Sep 14; . doi: 10.1111/bph.16242Authors: Akerman S, Goadsby PJ, Romero-Reyes M Little is known of how the presence of cranial autonomic symptoms (CAS) in cluster headache and migraine may contribute to their severe headache phenotype. However, this strong association points…
Content and Quality of Mobile Apps for the Monitoring of Musculoskeletal or Neuropathic Pain in Australia: Systematic Evaluation.
Source: JMIR Mhealth Uhealth 2023 Sep 13; 11. doi: 10.2196/46881Authors: Simmich J, Ross MH, Andrews NE, Vaezipour A, Russell TG Mobile apps offer a potential mechanism for people with persistent pain to monitor pain levels conveniently within their own environment and for clinicians to remotely…
Cryotherapy following total knee replacement.
Source: Cochrane Database Syst Rev 2023 Sep 14; 9. doi: 10.1002/14651858.CD007911.pub3Authors: Aggarwal A, Adie S, Harris IA, Naylor J Total knee replacement (TKR) is a common intervention for people with end-stage symptomatic knee osteoarthritis, resulting in significant improvements in pain, function and quality of life…
Immediate hypnosis effects and outcome predictors in chronic nociplastic pain.
Source: Am J Clin Hypn 2023 Sep 14; . doi: 10.1080/00029157.2023.2243618Authors: Kaczmarska AD, Rutkowski K, Mielimąka M This study used data from a randomized controlled trial on the efficacy of hypnosis with analgesic suggestions relative to hypnosis with nonspecific suggestions to explore two areas. The…
Hypothetical framework for post-COVID 19 condition based on a fibromyalgia pathogenetic model.
Source: Clin Rheumatol 2023 Sep 14; . doi: 10.1007/s10067-023-06743-0Authors: Martínez-Lavín M, Miguel-Álvarez A There is a clear clinical overlap between fibromyalgia, myalgic encephalomyelitis, and post-COVID 19 condition. Chronic fatigue, cognitive impairment, and widespread pain characterize these 3 syndromes. A steady line of investigation posits fibromyalgia…
Fully Implantable Neurostimulation System for Long-term Behavioral Animal Study.
Source: IEEE Trans Neural Syst Rehabil Eng 2023 Sep 14; PP. doi: 10.1109/TNSRE.2023.3315371Authors: Kang W, Lee J, Choi W, Kim J, Kim J, Park SM Spinal cord stimulation (SCS) is an emerging therapeutic option for patients with neuropathic pain due to spinal cord injury (SCI)….
Virtual reality facilitated exercise improves pain perception: A crossover study.
Source: J Clin Anesth 2023 Sep 12; 91. doi: 10.1016/j.jclinane.2023.111257Authors: Rodriguez ST, Makarewicz N, Wang EY, Zuniga-Hernandez M, Titzler J, Jackson C, Suen MY, Rosales O, Caruso TJ Both virtual reality (VR) and exercise are recognized for their analgesic and anxiolytic properties. The purpose of…
Truxillic acid monoamides as fatty acid binding protein 5 inhibitors.
Source: Bioorg Med Chem 2023 Sep 04; 94. doi: 10.1016/j.bmc.2023.117464Authors: Zhu C, Schutz L, Jayanetti K, Takemura K, Doswell F, Wang L, Ojima I, Kaczocha M Fatty acid binding proteins (FABPs) are intracellular chaperones that deliver bioactive lipids to cytosolic enzymes and nuclear receptors, thereby…
Activation of kappa opioid receptor (KOR) inhibits estrogen receptor (ER)-positive breast cancer through the KOR-ER-XBP1 pathway.
Source: Biomed Pharmacother 2023 Sep 12; 167. doi: 10.1016/j.biopha.2023.115462Authors: Shi Y, Zhang Y, Yu S, Luo J, Pan Z, Wang X, Tian J Opioids are commonly used in patients with breast cancer (BC), both for perioperative analgesia and for the relief of chronic cancer pain….
Impact of state opioid laws on prescribing in trauma patients.
Source: Surgery 2023 Sep 12; . doi: 10.1016/j.surg.2023.08.006Authors: Kelm JD, Aubry ST, Cain-Nielsen AH, Scott JW, Oliphant BW, Sangji NF, Waljee JF, Hemmila MR Excessive opioid prescribing has resulted in opioid diversion and misuse. In July 2018, Michigan’s Public Act 251 established a state-wide policy…
Folate-conjugated near-infrared fluorescent perfluorocarbon nanoemulsions as theranostics for activated macrophage COX-2 inhibition.
Source: Sci Rep 2023 Sep 14; 13(1). doi: 10.1038/s41598-023-41959-9Authors: Vichare R, Crelli C, Liu L, McCallin R, Cowan A, Stratimirovic S, Herneisey M, Pollock JA, Janjic JM Activated macrophages play a critical role in the orchestration of inflammation and inflammatory pain in several chronic diseases….
Fatty acid binding proteins are novel modulators of synaptic epoxyeicosatrienoic acid signaling in the brain.
Source: Sci Rep 2023 Sep 14; 13(1). doi: 10.1038/s41598-023-42504-4Authors: Glaser ST, Jayanetti K, Oubraim S, Hillowe A, Frank E, Jong J, Wang L, Wang H, Ojima I, Haj-Dahmane S, Kaczocha M Fatty acid binding proteins (FABPs) govern intracellular lipid transport to cytosolic organelles and nuclear…
rTMS targeted to the secondary somatosensory cortex influences sleep in CRPS patients, as measured with the OURA ring.
Source: Brain Behav 2023 Sep 12; . doi: 10.1002/brb3.3252Authors: Vanhanen J, Kujala J, Liljeström M, Kalso E, Virkkala J, Harno H Chronic pain associates with various sleep problems. Patients with complex regional pain syndrome (CRPS) often report impaired sleep, but objective measurements of sleep in…
Global research trends of nanotechnology for pain management.
Source: Front Bioeng Biotechnol 2023; 11. doi: 10.3389/fbioe.2023.1249667Authors: Zhu Y, Yao Y, Kuang R, Chen Z, Du Z, Qu S Nanotechnology has been increasingly used in healthcare during recent years. However, the systematic evaluation of research on nanotechnology for pain management is lacking. In this…
The Role of Neuroinflammation in Complex Regional Pain Syndrome: A Comprehensive Review.
Source: J Pain Res 2023; 16. doi: 10.2147/JPR.S423733Authors: Wen B, Pan Y, Cheng J, Xu L, Xu J Complex Regional Pain Syndrome (CRPS) is an excess and/or prolonged pain and inflammation condition that follows an injury to a limb. The pathogenesis of CRPS is multifaceted…
Development of the Chronic Pain Cognition Scale: A Culture-Sensitive Pain Measurement in Chinese.
Source: J Pain Res 2023; 16. doi: 10.2147/JPR.S422197Authors: Wu CH, Chou WH, Long YH, Yang HH, Lin T, Yang CC, Sun WZ, Chen CC, Lin CP People with pain problems are highly vulnerable to cultural disparities, and it is imperative to reduce these inequalities. This…
Elucidating individual differences in chronic pain and whole person health with allostatic load biomarkers.
Source: Brain Behav Immun Health 2023 Nov; 33. doi: 10.1016/j.bbih.2023.100682Authors: Mickle AM, Tanner JJ, Olowofela B, Wu S, Garvan C, Lai S, Addison A, Przkora R, Edberg JC, Staud R, Redden D, Goodin BR, Price CC, Fillingim RB, Sibille KT Chronic pain is a stressor…
Role of the GRP/GRPR System in Regulating Brain Functions.
Source: ACS Chem Neurosci 2023 Sep 13; . doi: 10.1021/acschemneuro.3c00392Authors: Zhao T, Chen A, Dai D, Li Z, Gao XF, Xiong L Re-examining the relationship between neuropeptide systems and neural circuits will help us to understand more intensively the critical role of neuropeptides in brain…