September 30-October 6, 2023
Showing 1-25 of 76.
A humanized chemogenetic system inhibits murine pain-related behavior and hyperactivity in human sensory neurons.
Source: Sci Transl Med 2023 Oct 04; 15(716). doi: 10.1126/scitranslmed.adh3839 Authors: Perez-Sanchez J, Middleton SJ, Pattison LA, Hilton H, Ali Awadelkareem M, Zuberi SR, Renke MB, Hu H, Yang X, Clark AJ, St John Smith E, Bennett DL Hyperexcitability in sensory neurons is known to…
Role of pattern recognition receptors in chemotherapy-induced neuropathic pain.
Source: Brain 2023 Oct 03;. doi: 10.1093/brain/awad339 Authors: Araldi D, Khomula EV, Bonet IJM, Bogen O, Green PG, Levine JD Progress in the development of effective chemotherapy is producing a growing population of patients with acute and chronic painful chemotherapy-induced peripheral neuropathy (CIPN), a serious…
MYL3 protects chondrocytes from senescence by inhibiting clathrin-mediated endocytosis and activating of Notch signaling.
Source: Nat Commun 2023 Oct 04; 14(1). doi: 10.1038/s41467-023-41858-7 Authors: Cao H, Yang P, Liu J, Shao Y, Li H, Lai P, Wang H, Liu A, Guo B, Tang Y, Bai X, Li K As the unique cell type in articular cartilage, chondrocyte senescence is…
Pain and Hazardous Alcohol Use in Veterans in Primary Care: The Role of Affective Pain Interference and Alcohol Pain-Coping Perceptions.
Source: J Pain 2023 Sep 30; . doi: 10.1016/j.jpain.2023.09.020Authors: Moskal D, Loughran TA, Funderburk JS, Scharer J, Buckheit KA, Beehler GP Chronic pain and unhealthy alcohol use commonly co-occur and are associated with negative health outcomes. Veterans may be particularly vulnerable to these conditions, yet…
Photic Sensitization is Mediated by Cortico-Accumbens Pathway in Rats with Trigeminal Neuropathic Pain.
Source: Prog Neurobiol 2023 Sep 28; . doi: 10.1016/j.pneurobio.2023.102533Authors: Ma J, Huang X, Li Z, Wang S, Yan X, Huang D, Zhou H Exposure to light stimuli may trigger or exacerbate perception of pain, also known as a common yet debilitating symptom of photophobia in…
Presynaptic glutamate receptors in nociception.
Source: Pharmacol Ther 2023 Sep 30; . doi: 10.1016/j.pharmthera.2023.108539Authors: Xie RG, Xu GY, Wu SX, Luo C Chronic pain is a frequent, distressing and poorly understood health problem. Plasticity of synaptic transmission in the nociceptive pathways after inflammation or injury is assumed to be an…
miR-199a-3p suppresses neuroinflammation by directly targeting MyD88 in a mouse model of bone cancer pain.
Source: Life Sci 2023 Sep 30; . doi: 10.1016/j.lfs.2023.122139Authors: Saadh MJ, Rashed AB, Jamal A, Castillo-Acobo RY, Kamal MA, Cotrina-Aliaga JC, Gonzáles JLA, Alothaim AS, Alhoqail WA, Ahmad F, Lakshmaiya N, Amin AH, Younus DG, Rojas GGR, Bahrami A, Akhavan-Sigari R Pain is a profoundly…
Discovery of novel TLR4/MD-2 inhibitors: Receptor structure-based virtual screening studies and anti-inflammatory evaluation.
Source: Bioorg Chem 2023 Sep 27; 141. doi: 10.1016/j.bioorg.2023.106880Authors: Zhang T, Xing S, Du J, Xia J, Dong S, Li Z, Liu Z, Song Y In this study, a receptor structure-based virtual screening strategy was constructed using a computer-aided drug design. First, the compounds were…
RALY participates in nerve trauma-induced nociceptive hypersensitivity through triggering eIF4G2 gene expression in primary sensory neurons.
Source: Br J Pharmacol 2023 Oct 02; . doi: 10.1111/bph.16259Authors: Huang L, Sharma D, Feng X, Pan Z, Wu S, Munoz D, Bekker A, Hu H, Tao YX Peripheral nerve trauma-induced dysregulation of pain-associated genes in the primary sensory neurons of dorsal root ganglion (DRG)…
Mechanosensing Piezo channels in gastrointestinal disorders.
Source: J Clin Invest 2023 Oct 02; 133(19). doi: 10.1172/JCI171955Authors: Swain SM, Liddle RA All cells in the body are exposed to physical force in the form of tension, compression, gravity, shear stress, or pressure. Cells convert these mechanical cues into intracellular biochemical signals; this…
Recent advances in the study of anesthesia-and analgesia-related mechanisms of S-ketamine.
Source: Front Pharmacol 2023; 14. doi: 10.3389/fphar.2023.1228895Authors: Zhou JS, Peng GF, Liang WD, Chen Z, Liu YY, Wang BY, Guo ML, Deng YL, Ye JM, Zhong ML, Wang LF Ketamine is a racemic mixture of equal amounts of R-ketamine and S-ketamine and is well known…
Mapping Structural Distribution and Gating-Property Impacts of Disease-Associated Missense Mutations in Voltage-Gated Sodium Channels.
Source: bioRxiv 2023 Sep 23; . doi: 10.1101/2023.09.20.558623Authors: Ahangar AA, Elhanafy E, Blanton H, Li J Thousands of voltage-gated sodium (Nav) channel variants contribute to a variety of disorders, including epilepsy, autism, cardiac arrhythmia, and pain disorders. Yet variant effects of more mutations remain unclear….
Intrinsic control of DRG sensory neuron diversification by Pten.
Source: bioRxiv 2023 Aug 06; . doi: 10.1101/2023.08.04.552039Authors: Fernandez A, Sarn N, Eng C, Wright KM Phosphatase and tensin homolog (PTEN) modulates intracellular survival and differentiation signaling pathways downstream of neurotrophin receptors in the developing peripheral nervous system (PNS). Although well-studied in the context of…
Single nucleotide polymorphisms and sickle cell disease-related pain: a systematic review.
Source: Front Pain Res (Lausanne) 2023; 4. doi: 10.3389/fpain.2023.1223309Authors: Gehling GM, Powell-Roach K, Wilkie DJ, Dungan JR Scientists have speculated genetic variants may contribute to an individual’s unique pain experience. Although research exists regarding the relationship between single nucleotide polymorphisms and sickle cell disease-related pain,…
Perspectives on the insidious nature of pain metaphor: we literally need to change our metaphors.
Source: Front Pain Res (Lausanne) 2023; 4. doi: 10.3389/fpain.2023.1224139Authors: Johnson MI, Hudson M, Ryan CG Metaphorical language is used to convey one thing as representative or symbolic of something else. Metaphor is used in figurative language but is much more than a means of delivering…
Chronic pain: its impact on the quality of life and gender.
Source: Front Pain Res (Lausanne) 2023; 4. doi: 10.3389/fpain.2023.1253460Authors: Pandelani FF, Nyalunga SLN, Mogotsi MM, Mkhatshwa VB Chronic pain poses a considerable challenge to individuals’ well-being, leading to decreased quality of life, limitations in daily functioning, and a higher reliance on healthcare services, resulting in…
Peripheral mechanisms of peripheral neuropathic pain.
Source: Front Mol Neurosci 2023; 16. doi: 10.3389/fnmol.2023.1252442Authors: Pacifico P, Coy-Dibley JS, Miller RJ, Menichella DM Peripheral neuropathic pain (PNP), neuropathic pain that arises from a damage or disease affecting the peripheral nervous system, is associated with an extremely large disease burden, and there is…
The pathological mechanisms of circRNAs in mediating intervertebral disc degeneration.
Source: Noncoding RNA Res 2023 Dec; 8(4). doi: 10.1016/j.ncrna.2023.09.004Authors: Li Y, Zhou S, Hu X, Lu S Lower back pain (LBP) is a worldwide health problem associated with significant economic and social burden. Intervertebral disc degeneration (IVDD) is a leading cause of LBP. Several studies…
The influence of intervertebral disc overloading on nociceptor calcium flickering.
Source: JOR Spine 2023 Sep; 6(3). doi: 10.1002/jsp2.1267Authors: Gewiess J, Eglauf J, Soubrier A, Grad S, Alini M, Peroglio M, Ma J Mechanical overloading can trigger a degenerative-like cascade in an organ culture of intervertebral disc (IVD). Whether the overloaded IVD can influence the activation…
Influence of Poloxamer 188 on Anti-Inflammatory and Analgesic Effects of Diclofenac-loaded Nanoemulsion: Formulation, Optimization and In Vitro/In Vivo Evaluation.
Source: J Pharm Sci 2023 Sep 28; . doi: 10.1016/j.xphs.2023.09.022Authors: Karami Z, Zanjani MS, Andalib S, Babaie H, Aminoroaia P In this study, a polymer-stabilized nanoemulsion (PNE) was developed to improve the inflammatory and analgesic activities of diclofenac (DA). DA-PNEs were prepared from sesame oil…
White matter changes in young and middle-aged males with chronic prostatitis/chronic pelvic pain syndrome: Tract-based spatial statistics analysis.
Source: Eur J Neurosci 2023 Oct 01; . doi: 10.1111/ejn.16154Authors: Lan X, Zhu XY, Bai WX, Liu HP, Wang H, Dun WH, Guo CG, Zhang M, Niu X The supraspinal mechanism plays a key role in developing and maintaining chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS)….
Progesterone receptor activation regulates sensory sensitivity and migraine susceptibility.
Source: J Pain 2023 Sep 28; . doi: 10.1016/j.jpain.2023.09.017Authors: Joshi S, Williamson J, Moosa S, Kapur J Women develop chronic pain during their reproductive years more often than men, and estrogen and progesterone regulate this susceptibility. We tested whether brain progesterone receptor (PR) signaling regulates…
Achyranthes bidentate extracts protect the IL-1β-induced osteoarthritis of SW1353 chondrocytes.
Source: J Biosci Bioeng 2023 Sep 29; . doi: 10.1016/j.jbiosc.2023.09.008Authors: Xiong H, Huang TY, Chang YL, Su WT Osteoarthritis, the most common joint disease worldwide, is a degenerative disease characterized by cartilage degeneration and inflammation. The active ingredients in the traditional Chinese medicinal plant Achyranthes…
Development and validation of a caregiver-reported Numeric Rating Scale for measuring worst scratch/itch in patients aged 6 months to younger than 6 years with atopic dermatitis.
Source: J Am Acad Dermatol 2023 Sep 29; . doi: 10.1016/j.jaad.2023.08.104Authors: Paller AS, Siegfried E, Marron SE, Clark M, DiBenedetti D, Nelson L, Chao J, Bansal A, Chuang CC, Wang Z Pubmed ID: https://pubmed.ncbi.nlm.nih.gov/37778662/
A novel endomorphin-2/salmon calcitonin hybrid peptide with enhancing anti-allodynic and anti-anxiety effects.
Source: Peptides 2023 Sep 29; . doi: 10.1016/j.peptides.2023.171108Authors: Huo Y, Cheng C, Wang S, Li L, Rong Z, Su C, Li F, Li Y, Yang L Pain, a worldwide problem with a high incidence and complex pathogenesis, has attracted the attention of pharmaceutical enterprises for…