September 23-29, 2023
Showing 1-25 of 68.
Sex differences in visceral sensitivity and brain activity in a rat model of comorbid pain: a longitudinal study.
Source: Pain 2023 Sep 27;. doi: 10.1097/j.pain.0000000000003074 Authors: Da Silva JT, Hernandez-Rojas LG, Mekonen HK, Hanson S, Melemedjian O, Scott AJ, Ernst RK, Seminowicz DA, Traub RJ Temporomandibular disorder (TMD) and irritable bowel syndrome (IBS) are 2 chronic overlapping pain conditions (COPCs) that present with…
Thiostrepton alleviates experimental colitis by promoting RORγt ubiquitination and modulating dysbiosis.
Source: Cell Mol Immunol 2023 Sep 26;. doi: 10.1038/s41423-023-01085-y Authors: Luo Y, Liu C, Luo Y, Zhang X, Li J, Hu C, Yang S Thiostrepton (TST) is a natural antibiotic with pleiotropic properties. This study aimed to elucidate the therapeutic effect of TST on experimental…
The thalamic reticular nucleus-lateral habenula circuit regulates depressive-like behaviors in chronic stress and chronic pain.
Source: Cell Rep 2023 Sep 21; 42(10). doi: 10.1016/j.celrep.2023.113170 Authors: Wang XY, Xu X, Chen R, Jia WB, Xu PF, Liu XQ, Zhang Y, Liu XF, Zhang Y Chronic stress and chronic pain are two major predisposing factors to trigger depression. Enhanced excitatory input to…
Large-scale momentary brain co-activation patterns are associated with hyperalgesia and mediate focal neurochemistry and cross-network functional connectivity in fibromyalgia.
Source: Pain 2023 Sep 26; . doi: 10.1097/j.pain.0000000000002973Authors: Mawla I, Huang Z, Kaplan CM, Ichesco E, Waller N, Larkin TE, Zöllner HJ, Edden RAE, Harte SE, Clauw DJ, Mashour GA, Napadow V, Harris RE Fibromyalgia has been characterized by augmented cross-network functional communication between the…
Exploring the Effect of Pain Sensitive Questionnaire on Guiding Intravenous Analgesia After Cesarean Section: A Randomised Double Blind Controlled Trial.
Source: J Pain Res 2023; 16. doi: 10.2147/JPR.S412131Authors: Liu S, Liu S, Gu D, Zhao X, Zhang H, Deng C, Gu Y This study investigates the effect of the Pain Sensitivity Questionnaire (PSQ) in guiding patient controlled intravenous analgesia (PCIA) on postoperative analgesia in women…
UnCRMPing Nav1.7 to treat trigeminal neuropathic pain.
Source: Pain 2023 Sep 06; . doi: 10.1097/j.pain.0000000000003054Authors: Antunes FTT, Zamponi GW Pubmed ID: https://pubmed.ncbi.nlm.nih.gov/37751533/
Intranasal CRMP2-Ubc9 inhibitor regulates NaV1.7 to alleviate trigeminal neuropathic pain.
Source: Pain 2023 Sep 26; . doi: 10.1097/j.pain.0000000000003053Authors: Loya-Lopez SI, Allen HN, Duran P, Calderon-Rivera A, Gomez K, Kumar U, Shields R, Zeng R, Dwivedi A, Saurabh S, Korczeniewska OA, Khanna R Dysregulation of voltage-gated sodium NaV1.7 channels in sensory neurons contributes to chronic pain…
Effect of vitamin D supplementation on circulating level of autophagosome protein LC3A, inflammation, and physical performance in knee osteoarthritis.
Source: Clin Transl Sci 2023 Sep 25; . doi: 10.1111/cts.13646Authors: Saengsiwaritt W, Jittikoon J, Chaikledkaew U, Tawonsawatruk T, Honsawek S, Udomsinprasert W Aberrant autophagic activity is observed in osteoarthritic joints. Vitamin D was shown to alleviate not only osteoarthritis severity, but also autophagy process. However,…
ACCEPTANCE AND COMMITMENT THERAPY FOR CHRONIC PAIN: AN OVERVIEW OF SYSTEMATIC REVIEWS WITH META-ANALYSIS OF RANDOMIZED CLINICAL TRIALS.
Source: J Pain 2023 Sep 23; . doi: 10.1016/j.jpain.2023.09.013Authors: Martinez-Calderon J, García-Muñoz C, Rufo-Barbero C, Matias-Soto J, Cano-García FJ This overview of reviews aimed to summarize the evidence from systematic reviews and meta-analysis of randomised clinical trials of the efficacy of Acceptance and Commitment Therapy…
Cannabis constituents for chronic neuropathic pain; reconciling the clinical and animal evidence.
Source: J Neurochem 2023 Sep 25; . doi: 10.1111/jnc.15964Authors: Sokolaj E, Assareh N, Anderson K, Aubrey KR, Vaughan CW Chronic neuropathic pain is a debilitating pain syndrome caused by damage to the nervous system that is poorly served by current medications. Given these problems, clinical…
2023 American College of Rheumatology and American Association of Hip and Knee Surgeons Clinical Practice Guideline for the Optimal Timing of Elective Hip or Knee Arthroplasty for Patients With Symptomatic Moderate-to-Severe Osteoarthritis or Advanced Symptomatic Osteonecrosis With Secondary Arthritis for Whom Nonoperative Therapy Is Ineffective.
Source: Arthritis Rheumatol 2023 Sep 25; . doi: 10.1002/art.42630Authors: Hannon CP, Goodman SM, Austin MS, Yates A, Guyatt G, Aggarwal VK, Baker JF, Bass P, Bekele DI, Dass D, Ghomrawi HMK, Jevsevar DS, Kwoh CK, Lajam CM, Meng CF, Moreland LW, Suleiman LI, Wolfstadt J,…
Subgrouping of facilitatory or inhibitory conditioned pain modulation responses in patients with chronic knee pain. Explorative analysis from a multicentre trial.
Source: Eur J Pain 2023 Sep 25; . doi: 10.1002/ejp.2185Authors: Larsen JB, Madeleine P, Sørensen LB, Sachau J, Otto JC, Baron R, Arendt-Nielsen L Facilitatory and inhibitory conditioned pain modulation (CPM) responses are observed in healthy volunteers and chronic pain patients, but the clinical implications…
Pioneers in Dermatology and Venereology: An interview with Professor Gil Yosipovitch.
Source: J Eur Acad Dermatol Venereol 2023 Oct; 37(10). doi: 10.1111/jdv.19396Authors: Yosipovitch G Pubmed ID: https://pubmed.ncbi.nlm.nih.gov/37746756/
A state-of-the-art review of functional magnetic resonance imaging technique integrated with advanced statistical modeling and machine learning for primary headache diagnosis.
Source: Front Hum Neurosci 2023; 17. doi: 10.3389/fnhum.2023.1256415Authors: Li ML, Zhang F, Chen YY, Luo HY, Quan ZW, Wang YF, Huang LT, Wang JH Primary headache is a very common and burdensome functional headache worldwide, which can be classified as migraine, tension-type headache (TTH), trigeminal…
Virtual reality in managing Complex Regional Pain Syndrome (CRPS): a scoping review.
Source: Front Neurol 2023; 14. doi: 10.3389/fneur.2023.1069381Authors: Arcos-Holzinger M, Biebl JT, Storz C, Gutmann M, Azad SC, Holzapfel BM, Kraft E Complex Regional Pain Syndrome (CRPS) is a severe pain disorder that does not yet have a specific treatment. Patients with CRPS not only suffer…
Dendrite intercalation between epidermal cells tunes nociceptor sensitivity to mechanical stimuli in Drosophila larvae.
Source: bioRxiv 2023 Sep 15; . doi: 10.1101/2023.09.14.557275Authors: Luedke KP, Yoshino J, Yin C, Jiang N, Huang JM, Huynh K, Parrish JZ An animal’s skin provides a first point of contact with the sensory environment, including noxious cues that elicit protective behavioral responses. Nociceptive somatosensory…
Effects of circadian disruption via dim light at night in C57BL6/J mice on recovery after spinal cord injury.
Source: bioRxiv 2023 Sep 16; . doi: 10.1101/2023.09.15.557980Authors: Aldrich JC, Scheinfeld AR, Lee SE, Mahach KM, Van de Veire BC, Fonken LK, Gaudet AD Spinal cord injury (SCI) can cause long-lasting locomotor deficits, pain, and mood disorders. Anatomical and functional outcomes are exacerbated by inflammation…
The role of TRPV1 in RA pathogenesis: worthy of attention.
Source: Front Immunol 2023; 14. doi: 10.3389/fimmu.2023.1232013Authors: Qu Y, Fu Y, Liu Y, Liu C, Xu B, Zhang Q, Jiang P Transient receptor potential cation channel subfamily V member 1 (TRPV1) is a Capermeable, non-selective cation channel that is found primarily in sensory nerve fibres….
Characterisation of common genetic variants in P2RX7 and their contribution to chronic pain conditions.
Source: J Pain 2023 Sep 22; . doi: 10.1016/j.jpain.2023.09.011Authors: Zorina-Lichtenwalter K, Ase AR, Verma V, Parra AIM, Komarova S, Khadra A, Séguéla P, Diatchenko L The ATP-gated channel P2X7 is encoded by a gene enriched for common nonsynonymous variants. Many of these variants have functional…
Grieving “The Death of Possibility”: Memorable Messages of (Dis)Enfranchised Loss in Invisible, Physical Illness.
Source: Health Commun 2023 Sep 19; . doi: 10.1080/10410236.2023.2257942Authors: Gunning JN, Taladay-Carter C Guided by theories of communicative disenfranchisement (TCD) and memorable messages (ToMM), this study analyzes 60 open-ended survey responses detailing experiences of grief following the onset of invisible, physical illness (e.g. chronic overlapping…
Network analyses reveal the interaction between physical features, fear of movement and neck pain and disability in people with acute and chronic whiplash-associated disorders.
Source: Eur J Pain 2023 Sep 19; . doi: 10.1002/ejp.2184Authors: Anarte-Lazo E, Liew BXW, Devecchi V, Bernal-Utrera C, Rodriguez-Blanco C, Falla D A network analysis can be used to quantitatively assess and graphically describe multiple interactions. This study applied network analyses to determine the interaction…
Depression and anxiety mediate the relationship between illness representations and perceived distress in patients with chronic pain.
Source: Sci Rep 2023 Sep 19; 13(1). doi: 10.1038/s41598-023-42156-4Authors: Rometsch C, Teufel M, Skoda EM, Schweda A, Cosci F, Zipfel S, Stengel A, Salewski C Illness representations explain the individual’s perception and processing of health-related information. In a chronic condition such as persistent pain, illness…
Peripheral nerve stimulation for the treatment of chronic knee pain.
Source: Sci Rep 2023 Sep 20; 13(1). doi: 10.1038/s41598-023-42608-xAuthors: Früh A, Sargut TA, Hussein A, Muskala B, Kuckuck A, Brüßeler M, Vajkoczy P, Bayerl S The average age of our population is increasing, resulting in a high incidence of chronic degenerative knee pathologies. Several treatment…
Description of Novel Molecular Factors in Lumbar DRGs and Spinal Cord Factors Underlying Development of Neuropathic Pain Component in the Animal Model of Osteoarthritis.
Source: Mol Neurobiol 2023 Sep 21; . doi: 10.1007/s12035-023-03619-xAuthors: Malek N, Mlost J, Kostrzewa M, Rajca J, Starowicz K Osteoarthritis (OA) is one of the most common joint disorder, with pain accompanied by functional impairment, as the most pronounced clinical symptom. Currently used pharmacotherapy involves…
Fasting-mimicking diet alleviates inflammatory pain by inhibiting neutrophil extracellular traps formation and neuroinflammation in the spinal cord.
Source: Cell Commun Signal 2023 Sep 21; 21(1). doi: 10.1186/s12964-023-01258-2Authors: Li T, Yue Y, Ma Y, Zhong Z, Guo M, Zhang J, Wang Z, Miao C Neutrophil extracellular traps (NETs) promote neuroinflammation and, thus, central nervous system (CNS) disease progression. However, it remains unclear whether…