October 7-13, 2023
Showing 1-25 of 96.
Alleviation of neuropathic pain with neuropeptide Y requires spinal Npy1r interneurons that co-express Grp.
Source: JCI Insight 2023 Oct 12;. doi: 10.1172/jci.insight.169554 Authors: Nelson TS, Allen HN, Basu P, Prasoon P, Nguyen EK, Arokiaraj CM, Santos DF, Seal RP, Ross SE, Todd AJ, Taylor BK Neuropeptide Y targets the Y1 receptor (Y1) in the spinal dorsal horn (DH) to…
Functional and anatomical analyses of active spinal circuits in a mouse model of chronic pain.
Source: Pain 2023 Oct 10;. doi: 10.1097/j.pain.0000000000003068 Authors: Targowska-Duda KM, Peters D, Marcus JL, Zribi G, Toll L, Ozawa A Decades of efforts in elucidating pain mechanisms, including pharmacological, neuroanatomical, and physiological studies have provided insights into how nociceptive information transmits from the periphery to…
Spinal-specific super enhancer in neuropathic pain.
Source: J Neurosci 2023 Oct 05;. doi: 10.1523/JNEUROSCI.1006-23.2023 Authors: Tao Y, Wang QH, Li XT, Sun RH, Xu HJ, Liu Y, Zhang M, Li SY, Yang L, Wang HJ, Hao LY, Cao JL, Pan Z Dysfunctional gene expression in nociceptive pathways plays a critical role…
Recent advances in the repair of degenerative intervertebral disc for preclinical applications.
Source: Front Bioeng Biotechnol 2023; 11. doi: 10.3389/fbioe.2023.1259731Authors: Ying Y, Cai K, Cai X, Zhang K, Qiu R, Jiang G, Luo K The intervertebral disc (IVD) is a load-bearing, avascular tissue that cushions pressure and increases flexibility in the spine. Under the influence of obesity,…
Evidence of a genetic background predisposing to complex regional pain syndrome type 1.
Source: J Med Genet 2023 Oct 10; . doi: 10.1136/jmg-2023-109236Authors: Shaikh SS, Goebel A, Lee MC, Nahorski MS, Shenker N, Pamela Y, Drissi I, Brown C, Ison G, Shaikh MF, Kuttikat A, Woods WA, Dixit A, Stouffer K, Clarke MC, Menon DK, Woods CG Complex…
Ferroptosis: a new regulatory mechanism in neuropathic pain.
Source: Front Aging Neurosci 2023; 15. doi: 10.3389/fnagi.2023.1206851Authors: Li L, Guo L, Gao R, Yao M, Qu X, Sun G, Fu Q, Hu C, Han G Neuropathic pain (NP) is pain caused by damage to the somatosensory system. It is a common progressive neurodegenerative disease…
Neuropathic pain; what we know and what we should do about it.
Source: Front Pain Res (Lausanne) 2023; 4. doi: 10.3389/fpain.2023.1220034Authors: Smith PA Neuropathic pain can result from injury to, or disease of the nervous system. It is notoriously difficult to treat. Peripheral nerve injury promotes Schwann cell activation and invasion of immunocompetent cells into the site…
Editorial: Insights in pain mechanisms 2022.
Source: Front Pain Res (Lausanne) 2023; 4. doi: 10.3389/fpain.2023.1290621Authors: Alles SRA Pubmed ID: https://pubmed.ncbi.nlm.nih.gov/37810431/
Sensing of protease activity as a triggering mechanism of Th2 cell immunity and allergic disease.
Source: Front Allergy 2023; 4. doi: 10.3389/falgy.2023.1265049Authors: Meloun A, León B CD4 T-helper cell type 2 (Th2) cells mediate host defense against extracellular parasites, like helminths. However, Th2 cells also play a pivotal role in the onset and progression of allergic inflammatory diseases such as…
IL-1β-mediated inflammatory responses in intervertebral disc degeneration: Mechanisms, signaling pathways, and therapeutic potential.
Source: Heliyon 2023 Sep; 9(9). doi: 10.1016/j.heliyon.2023.e19951Authors: Li H, Pan H, Xiao C, Li H, Long L, Wang X, Luo S, Lyu K, Chen Y, Jiang L, Lu J, Shen H, Li S Intervertebral disc degeneration (IDD) has been widely recognized as the primary cause…
Transcriptome analysis in a humanized mouse model of familial dysautonomia reveals tissue-specific gene expression disruption in the peripheral nervous system.
Source: bioRxiv 2023 Oct 02; . doi: 10.1101/2023.09.28.559870Authors: Harripaul RS, Morini ES, Salani M, Logan E, Kirchner EG, Bolduc J, Chekuri A, Currall B, Yadav R, Erdin S, Talkowski ME, Gao D, Slaugenhaupt S Familial dysautonomia (FD) is a rare recessive neurodevelopmental disease caused by…
A suite of engineered mice for interrogating psychedelic drug actions.
Source: bioRxiv 2023 Sep 26; . doi: 10.1101/2023.09.25.559347Authors: Chiu YT, Deutch AY, Wang W, Schmitz GP, Huang KL, Kocak DD, Llorach P, Bowyer K, Liu B, Sciaky N, Hua K, Chen C, Mott SE, Niehaus J, DiBerto JF, English J, Walsh JJ, Scherrer G, Herman…
Headache among combat-exposed veterans and service members and its relation to mild traumatic brain injury history and other factors: a LIMBIC-CENC study.
Source: Front Neurol 2023; 14. doi: 10.3389/fneur.2023.1242871Authors: Walker WC, Clark SW, Eppich K, Wilde EA, Martin AM, Allen CM, Cortez MM, Pugh MJ, Walton SR, Kenney K Headache (HA) is a common persistent complaint following mild traumatic brain injury (mTBI), but the association with remote…
The Hidden Economic Consequences of Migraine to the UK Government: Burden-of-Disease Analysis Using a Fiscal Framework.
Source: J Health Econ Outcomes Res 2023; 10(2). doi: 10.36469/001c.87790Authors: Martins R, Large S, Russell R, Surmay G, Connolly MP Migraine is a highly prevalent and incapacitating neurological disorder associated with the highest global disability burden in people aged 15 to 49 years. Europe has…
1,4-Diaryl-1,2,3-triazole neolignan-celecoxib hybrids inhibit experimental arthritis induced by zymosan.
Source: Inflammopharmacology 2023 Oct 08; . doi: 10.1007/s10787-023-01345-3Authors: Felipe JL, Bonfá IS, Lossavaro PKMB, Lencina JS, B Carvalho D, Candeloro L, Ferreira GIS, das Neves AR, Souza MIL, Silva-Filho SE, Baroni ACM, Toffoli-Kadri MC Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes cartilage…
Systemic administration of NIS-lncRNA antisense oligonucleotide alleviates neuropathic pain.
Source: Neurosci Lett 2023 Oct 06; . doi: 10.1016/j.neulet.2023.137512Authors: Berkmana T, Li X, Liang Y, Korban A, Bekker A, Tao YX The antisense oligonucleotide (ASO) is an FDA-approved strategy in the treatment of neurological diseases. We have shown the viability of using intrathecal ASO to…
A comprehensive painkillers screening by assessing zebrafish behaviors after caudal fin amputation.
Source: Biomed Pharmacother 2023 Oct 06; 168. doi: 10.1016/j.biopha.2023.115641Authors: Audira G, Huang JC, Chen KH, Kurnia KA, Vasquez RD, Roldan MJM, Lai YH, Hsiao CD, Yen CY Recently, the usage of zebrafish for pain studies has increased in the past years, especially due to its…
Diagnostic delay in psoriatic arthritis: insights from a nationwide multicenter study.
Source: Rheumatol Int 2023 Oct 08; . doi: 10.1007/s00296-023-05479-zAuthors: Kılıç G, Kılıç E, Tekeoğlu İ, Sargın B, Cengiz G, Balta NC, Alkan H, Kasman SA, Şahin N, Orhan K, Gezer İA, Keskin D, Mülkoğlu C, Reşorlu H, Ataman Ş, Bal A, Duruöz MT, Kücükakkaş O,…
Nanocrystals Slow-Releasing Ropivacaine and Doxorubicin to Synergistically Suppress Tumor Recurrence and Relieve Postoperative Pain.
Source: ACS Nano 2023 Oct 08; . doi: 10.1021/acsnano.3c05831Authors: Peng F, Liu J, Chen J, Wu W, Zhang Y, Zhao G, Kang Y, Gong D, He L, Wang J, Zhang W, Qiu F Although surgical resection provides a straightforward and effective treatment for most malignant…
GFAP-NpHR mediated optogenetic inhibition of trigeminal nucleus caudalis attenuates hypersensitive behaviors and thalamic discharge attributed to infraorbital nerve constriction injury.
Source: J Headache Pain 2023 Oct 11; 24(1). doi: 10.1186/s10194-023-01669-zAuthors: Kc E, Islam J, Kim HK, Park YS The significance of hyperactive astrocytes in neuropathic pain is crucial. However, the association between medullary astrocytes and trigeminal neuralgia (TN)-related pain processing is unclear. Here, we examined…
Canine, mouse, and human transient receptor potential ankyrin 1 (TRPA1) channels show different sensitivity to menthol or cold stimulation.
Source: J Vet Med Sci 2023 Oct 11; . doi: 10.1292/jvms.23-0327Authors: Yamaguchi T, Uchida K, Yamazaki J Transient receptor potential ankyrin 1 (TRPA1) is a nonselective cation channel that is activated by a variety of stimuli and acts as a nociceptor. Mouse and human TRPA1…
Signatures of necroptosis-related genes as diagnostic markers of endometriosis and their correlation with immune infiltration.
Source: BMC Womens Health 2023 Oct 11; 23(1). doi: 10.1186/s12905-023-02668-7Authors: Wang X, Zheng Q, Sun M, Liu L, Zhang H, Ying W Endometriosis (EMS) occurs when normal uterine tissue grows outside the uterus and causes chronic pelvic pain and infertility. Endometriosis-associated infertility is thought to…
Dedicated neuroimaging analysis in children with primary headaches: prevalence of lesions and a comparison between patients with and without migraines.
Source: BMC Med Imaging 2023 Oct 10; 23(1). doi: 10.1186/s12880-023-01122-2Authors: Jeon CW, Lim GY, Moon JU This study evaluated the prevalence and types of intracranial lesions through dedicated imaging analysis of primary headaches in children and compared them between patients with and without migraine. Pubmed…
Triptan non-response in specialized headache care: cross-sectional data from the DMKG Headache Registry.
Source: J Headache Pain 2023 Oct 10; 24(1). doi: 10.1186/s10194-023-01676-0Authors: Ruscheweyh R, Gossrau G, Dresler T, Freilinger T, Förderreuther S, Gaul C, Kraya T, Neeb L, Ruschil V, Straube A, Scheidt J, Jürgens TP Triptans are effective for many migraine patients, but some do not…
Retraction Note: Mechanisms Involved in Superiority of Angiotensin Receptor Blockade over ACE Inhibition in Attenuating Neuropathic Pain Induced in Rats.
Source: Neurotherapeutics 2023 Oct 10; . doi: 10.1007/s13311-023-01449-2Authors: Hegazy N, Rezq S, Fahmy A Pubmed ID: https://pubmed.ncbi.nlm.nih.gov/37817048/