October 26 - November 1, 2024
Showing 1-25 of 126.
Genetic associations of neuropathic pain and sensory profile in a deeply phenotyped neuropathy cohort.
Source: Pain 2024 Oct 29;. doi: 10.1097/j.pain.0000000000003463 Authors: Åkerlund M, Baskozos G, Li W, Themistocleous AC, Pascal MMV, Rayner NW, Attal N, Baron R, Baudic S, Bennedsgaard K, Bouhassira D, Comini M, Crombez G, Faber CG, Finnerup NB, Gierthmühlen J, Granovsky Y, Gylfadottir SS, Hébert…
Spatial, transcriptomic, and epigenomic analyses link dorsal horn neurons to chronic pain genetic predisposition.
Source: Cell Rep 2024 Oct 23; 43(11). doi: 10.1016/j.celrep.2024.114876 Authors: Arokiaraj CM, Leone MJ, Kleyman M, Chamessian A, Noh MC, Phan BN, Lopes BC, Corrigan KA, Cherupally VK, Yeramosu D, Franusich ME, Podder R, Lele S, Shiers S, Kang B, Kennedy MM, Chen V, Chen…
A functional exercise program improves pain and health related quality of life in patients with fibromyalgia: a randomized controlled trial.
Source: Adv Rheumatol 2024 Oct 24; 64(1). doi: 10.1186/s42358-024-00422-7Authors: Fernandes G, Nery M, Meireles SM, Santos R, Natour J, Jennings F Fibromyalgia is a non-inflammatory syndrome characterized by generalized muscle pain, with other symptoms. Numerous forms of physical training for this population have been studied…
Regional distribution of unbound eletriptan and sumatriptan in the CNS and PNS in rats: implications for a potential central action.
Source: J Headache Pain 2024 Oct 30; 25(1). doi: 10.1186/s10194-024-01894-0Authors: Svane N, Bällgren F, Ginosyan A, Kristensen M, Brodin B, Loryan I Triptans are potent 5-HT receptor agonists used in migraine therapy, thought to act through peripheral mechanisms. It remains unclear whether triptans cross the…
The cingulum: a central hotspot for the battle against chronic intractable pain?
Source: Brain Commun 2024; 6(5). doi: 10.1093/braincomms/fcae368Authors: Kollenburg L, Arnts H, Green A, Strauss I, Vissers K, Vinke S, Kurt E Chronic pain causes a major burden on patient’s lives, in part due to its profound socioeconomic impact. Despite the development of various pharmacological approaches…
Integrated manual therapies: IASP taskforce viewpoint.
Source: Pain Rep 2024 Dec; 9(6). doi: 10.1097/PR9.0000000000001192Authors: Draper-Rodi J, Newell D, Barbe MF, Bialosky J Manual therapy refers to a range of hands-on interventions used by various clinical professionals, such as osteopaths, osteopathic physicians, chiropractors, massage therapists, physiotherapists, and physical therapists, to treat patients…
Fatigue, sleep disturbance, and pain interference in children and adolescents with chronic pain: a longitudinal study.
Source: Pain 2024 Oct 30; . doi: 10.1097/j.pain.0000000000003432Authors: Roman-Juan J, Ceniza-Bordallo G, Sánchez-Rodríguez E, Jensen MP, Miró J Research has shown that pain and sleep disturbance often co-occur and influence each other over time in children and adolescents with chronic pain. Longitudinal studies examining the…
Estrous cycle regulates cephalic mechanical sensitivity and sensitization of the trigemino-cervical complex in a female rat model of chronic migraine.
Source: Pain 2024 Oct 30; . doi: 10.1097/j.pain.0000000000003459Authors: Barnet M, Descheemaeker A, Favier L, Moisset X, Schopp J, Dallel R, Artola A, Monconduit L, Antri M The higher incidence of migraines in women compared with men has led to the inclusion of female animals in…
Trajectories of cold but not mechanical sensitivity correspond with disability trajectories after whiplash injury.
Source: Pain 2024 Oct 30; . doi: 10.1097/j.pain.0000000000003461Authors: Farrell SF, Armfield NR, Kristjansson E, Niere K, Christensen SWM, Sterling M Developmental trajectories for neck disability after whiplash injury have been identified. Their relationship to cold and mechanical sensitivity trajectories is not known. We aimed to…
A Proposed Psychologic Clearance Algorithm for Spinal Cord Stimulation Implantation Supported by a Scoping Review.
Source: Neuromodulation 2024 Oct 30; . doi: 10.1016/j.neurom.2024.09.001Authors: Fisher K, Furtado-Pessoa-de-Mendonca L, Kaushal S, Sterling L, Hallo Carrasco A, Pagan Rosado R, Hallo C, Cael Aoki K, Caceres J, Prokop L, Rodriguez SE, Hunt CL Patients with refractory chronic pain may be considered for spinal…
Neuroprotective effect of chelidonic acid through oxidative stress reduction in paclitaxel-induced peripheral neuropathy in rats.
Source: Naunyn Schmiedebergs Arch Pharmacol 2024 Oct 31; . doi: 10.1007/s00210-024-03550-5Authors: Khairnar SI, Kulkarni YA, Singh K The present study evaluated the effect of chelidonic acid on paclitaxel-induced neuropathy in male Wistar rats. Neuropathy was induced by administering paclitaxel (2 mg/kg, i.p.) on 0, 2, 4,…
Neuroinflammatory Pathways Associated with Chronic Post-Thoracotomy Pain: A Review of Current Literature.
Source: Mol Neurobiol 2024 Oct 29; . doi: 10.1007/s12035-024-04565-yAuthors: Sherbini AHE, Hasheminia A, Gemae MR, Ansari F, Anood A, Saha T, Towe CW, El-Diasty M Chronic post-thoracotomy pain (CPTP) is a major clinical problem that affects up to 35-55% of patients undergoing thoracic incisions. Evidence…
Enhancing osteogenic differentiation of diabetic tendon stem/progenitor cells through hyperoxia: Unveiling ROS/HIF-1α signalling axis.
Source: J Cell Mol Med 2024 Oct; 28(20). doi: 10.1111/jcmm.70127Authors: Zhang M, Dai GC, Zhang YW, Lu PP, Wang H, Li YJ, Rui YF Diabetic calcific tendinopathy is the leading cause of chronic pain, mobility restriction, and tendon rupture in patients with diabetes. Tendon stem/progenitor…
ClC-1 Inhibition as a Mechanism for Accelerating Skeletal Muscle Recovery After Neuromuscular Block in Rats.
Source: Nat Commun 2024 Oct 28; 15(1). doi: 10.1038/s41467-024-53237-xAuthors: Skals M, Broch-Lips M, Skov MB, Riisager A, Ceelen J, Nielsen OB, Brull SJ, de Boer HD, Pedersen TH Neuromuscular blocking agents are used commonly to induce skeletal muscle relaxation during surgery. While muscle relaxation facilitates…
Transcriptome analysis of rheumatoid arthritis uncovers genes linked to inflammation-induced pain.
Source: Sci Rep 2024 Oct 29; 14(1). doi: 10.1038/s41598-024-77212-0Authors: Hall BE, Mazhar K, Macdonald E, Cassidy M, Doty M, Judkins C, Terse A, Shiers S, Tadros S, Yun S, Burton MD, Price TJ, Kulkarni AB Autoimmune diseases such as rheumatoid arthritis (RA) can promote states…
Chemokine CXCL13-CXCR5 signaling in neuroinflammation and pathogenesis of chronic pain and neurological diseases.
Source: Cell Mol Biol Lett 2024 Oct 29; 29(1). doi: 10.1186/s11658-024-00653-yAuthors: Zheng K, Chen M, Xu X, Li P, Yin C, Wang J, Liu B Chronic pain dramatically affects life qualities of the sufferers. It has posed a heavy burden to both patients and the…
Multisensory sensitivity in relation to pain: a scoping review of terminology and assessment.
Source: Pain Rep 2024 Dec; 9(6). doi: 10.1097/PR9.0000000000001193Authors: Dunne H, Frey-Law LA Chronic pain is a debilitating health problem affecting 20 million Americans annually. Most patients with chronic pain report negative impacts on daily function and quality of life, which can result in devastating emotional…
Reasons for Use and Perceived Effects of Medical Cannabis: A Cross-Sectional Statewide Survey.
Source: Med Cannabis Cannabinoids 2024; 7(1). doi: 10.1159/000540593Authors: Sajdeya R, Jugl S, Wang Y, Perez JG, Maloney S, Lopez-Quintero C, Goodin AJ, Winterstein AG, Cook RL Medical cannabis (MC) is available upon certification for one of several qualifying conditions in Florida, USA. Previous studies suggested…
Pediatric pain physician workforce: an assessment of supply and demand.
Source: Front Pain Res (Lausanne) 2024; 5. doi: 10.3389/fpain.2024.1390736Authors: Theriault CB, Burns T, Goldschneider K, Koka A, Logan D, Weisman SJ, Wilder RT, Windsor RB, Zempsky WT Many youth with pain lack access to pediatric pain expertise. There is a critical shortage of pediatric pain…
Chemical neurolysis of genicular nerves for chronic non-cancer knee pain: A scoping review.
Source: Pain Med 2024 Oct 30; . doi: 10.1093/pm/pnae109Authors: Tay MRJ, Mittal N, Yao S, Farag J Chemical neurolysis of the genicular nerves is a treatment option for intractable non-cancer knee pain. This scoping review synthesizes the available literature on the effectiveness, adverse effects and…
The Effect of Pexidartinib on Neuropathic Pain via Influences on Microglia and Neuroinflammation in Mice.
Source: Anesth Analg 2024 Oct 30; . doi: 10.1213/ANE.0000000000007239Authors: Yang L, Gomm A, Bai P, Ding W, Tanzi RE, Wang C, Shen S, Zhang C Chronic pain is a debilitating medical condition that lacks effective treatments. Increasing evidence suggests that microglia and neuroinflammation underlie pain…
‘Unmasking Pain’ through creativity: A phenomenological study of person-centred pain exploration for people living with chronic pain.
Source: PLoS One 2024; 19(10). doi: 10.1371/journal.pone.0312014Authors: Thompson K, Milligan J, Murphy A, Tabasam G, Johnson MI ‘Unmasking Pain’ is an innovative artist-led project to explore creative approaches for telling stories of life with persistent pain. The purpose of this qualitative study was to explore…
Attentional biases towards emotional information in chronic pain: A multilevel meta-analysis of eye-tracking studies.
Source: Acta Psychol (Amst) 2024 Oct 29; 250. doi: 10.1016/j.actpsy.2024.104555Authors: Robles E, Nieto I, Navas JF, Vázquez C This meta-analysis reviewed the existing literature on attentional biases towards emotional stimuli measured with eye-tracking methodologies in individuals with chronic pain. Pubmed ID: https://pubmed.ncbi.nlm.nih.gov/39476708/
Structure-guided discovery of bile acid derivatives for treating liver diseases without causing itch.
Source: Cell 2024 Oct 24; . doi: 10.1016/j.cell.2024.10.001Authors: Yang J, Zhao T, Fan J, Zou H, Lan G, Guo F, Shi Y, Ke H, Yu H, Yue Z, Wang X, Bai Y, Li S, Liu Y, Wang X, Chen Y, Li Y, Lei X Chronic…
SETD2 deficiency in peripheral sensory neurons induces allodynia by promoting NMDA receptor expression through NFAT5 in rodent models.
Source: Int J Biol Macromol 2024 Oct 28; . doi: 10.1016/j.ijbiomac.2024.136767Authors: Chen G, Gu P, Wu W, Yin Y, Pan L, Huang S, Lin W, Deng M Histone methylations play a crucial role in the development of neuropathic pain, and SET domain containing 2 (SETD2),…