November 4-10, 2023
Showing 1-25 of 79.
Inflammation-induced mitochondrial and metabolic disturbances in sensory neurons control the switch from acute to chronic pain.
Source: Cell Rep Med 2023 Oct 31;. doi: 10.1016/j.xcrm.2023.101265 Authors: Willemen HLDM, Santos Ribeiro PS, Broeks M, Meijer N, Versteeg S, Tiggeler A, de Boer TP, Małecki JM, Falnes PØ, Jans J, Eijkelkamp N Pain often persists in patients with an inflammatory disease, even when…
Epigenetic regulation of beta-endorphin synthesis in hypothalamic arcuate nucleus neurons modulates neuropathic pain in a rodent pain model.
Source: Nat Commun 2023 Nov 09; 14(1). doi: 10.1038/s41467-023-43022-7 Authors: Tao Y, Zhang Y, Jin X, Hua N, Liu H, Qi R, Huang Z, Sun Y, Jiang D, Snutch TP, Jiang X, Tao J Although beta-endorphinergic neurons in the hypothalamic arcuate nucleus (ARC) synthesize beta-endorphin…
4E-BP1-dependent translation in nociceptors controls mechanical hypersensitivity via TRIM32/type I interferon signaling.
Source: Sci Adv 2023 Nov 03; 9(44). doi: 10.1126/sciadv.adh9603 Authors: Wong C, Tavares-Ferreira D, Thörn Perez C, Sharif B, Uttam S, Amiri M, Lister KC, Hooshmandi M, Nguyen V, Séguéla P, Sonenberg N, Price TJ, Gkogkas CG, Khoutorsky A Activation of the mechanistic target of…
Advanced Magnetic Resonance Imaging and Molecular Imaging of the Painful Knee.
Source: Semin Musculoskelet Radiol 2023 Dec; 27(6). doi: 10.1055/s-0043-1775741Authors: Mostert JM, Dur NBJ, Li X, Ellermann JM, Hemke R, Hales L, Mazzoli V, Kogan F, Griffith JF, Oei EHG, van der Heijden RA Chronic knee pain is a common condition. Causes of knee pain include…
BDNF/TrkB Signaling Inhibition Suppresses Astrogliosis and Alleviates Mechanical Allodynia in a Partial Crush Injury Model.
Source: Exp Neurobiol 2023 Oct 31; 32(5). doi: 10.5607/en23031Authors: Phan TT, Jayathilake NJ, Lee KP, Park JM Neuropathic pain presents a formidable clinical challenge due to its persistent nature and limited responsiveness to conventional analgesic treatments. While significant progress has been made in understanding the…
A Practical Guide to Sigma-1 Receptor Positron Emission Tomography/Magnetic Resonance Imaging: A New Clinical Molecular Imaging Method to Identify Peripheral Pain Generators in Patients with Chronic Pain.
Source: Semin Musculoskelet Radiol 2023 Dec; 27(6). doi: 10.1055/s-0043-1775744Authors: Shen B, Yoon D, Castillo J, Biswal S Accurately identifying the peripheral pain generator in patients with chronic pain remains a major challenge for modern medicine. Millions of patients around the world suffer endlessly from difficult-to-manage…
Current status of GABA receptor subtypes in analgesia.
Source: Biomed Pharmacother 2023 Nov 05; 168. doi: 10.1016/j.biopha.2023.115800Authors: Qian X, Zhao X, Yu L, Yin Y, Zhang XD, Wang L, Li JX, Zhu Q, Luo JL Gamma-aminobutyric acid (GABA), a non-protein-producing amino acid synthesized from the excitatory amino acid glutamate via the enzyme glutamic…
A random forest algorithm-based prediction model for moderate to severe acute postoperative pain after orthopedic surgery under general anesthesia.
Source: BMC Anesthesiol 2023 Nov 06; 23(1). doi: 10.1186/s12871-023-02328-1Authors: Shi G, Liu G, Gao Q, Zhang S, Wang Q, Wu L, He P, Yu Q Postoperative pain is one of the most common complications after surgery. In order to detect early and intervene in time…
The effects of joint hypermobility on pain and functional biomechanics in adolescents with juvenile fibromyalgia: secondary baseline analysis from a pilot randomized controlled trial.
Source: BMC Pediatr 2023 Nov 06; 23(1). doi: 10.1186/s12887-023-04353-yAuthors: Black WR, DiCesare CA, Wright LA, Thomas S, Pfeiffer M, Kitchen K, Ting TV, Williams SE, Myer GD, Kashikar-Zuck S Joint hypermobility is a common clinical finding amongst hereditary connective tissue disorders that is observed in…
The role of chronic pain and pain anxiety in delay discounting of pain and monetary losses.
Source: Sci Rep 2023 Nov 06; 13(1). doi: 10.1038/s41598-023-46378-4Authors: Białaszek W, Mizak S, Ostaszewski P, Bąbel P Pain may alter intertemporal decisions by modifying the value of pain-related outcomes. For example, a person with chronic back pain may be faced with two choices: undergo surgery…
Chronic Pain Accelerates Cognitive Impairment by Reducing Hippocampal Neurogenesis may via CCL2/CCR2 Signaling in APP/PS1 Mice.
Source: Brain Res Bull 2023 Nov 04; . doi: 10.1016/j.brainresbull.2023.110801Authors: Chen L, Qin Q, Huang P, Cao F, Yin M, Xie Y, Wang W Patients with chronic pain often have cognitive impairment; this is especially true in elderly patients with neurodegenerative diseases such as Alzheimer’s…
Pain-Related Vertex Evoked Potentials. Comparison of Surface Electrical to Heat Stimulation.
Source: J Clin Neurophysiol 2023 Nov 01; 40(7). doi: 10.1097/WNP.0000000000000929Authors: Guiloff RJ, Campero M, Barraza GR, Treede RD, Matamala JM, Castillo JL Demonstration of nociceptive fiber abnormality is important for diagnosing neuropathic pain and small fiber neuropathies. This is usually assessed by brief heat pulses…
Impact of different CRPS phenotypes and diagnostic criteria on quantitative sensory testing outcomes: Systematic review and meta-analysis.
Source: Pain Med 2023 Oct 31; . doi: 10.1093/pm/pnad144Authors: Sobeeh MG, Hassan KA, Silva AG, Bruehl S This review and meta-analysis evaluated the impact of diagnostic criteria and clinical phenotypes on quantitative sensory testing (QST) outcomes in patients with complex regional pain syndrome (CRPS). Pubmed…
Sustained pain and macrophage infiltration in a mouse muscle contusion model.
Source: Muscle Nerve 2023 Nov 06; . doi: 10.1002/mus.28001Authors: Cortez I, Gaffney CM, Crelli CV, Lee E, Nichols JM, Pham HV, Mehdi S, Janjic JM, Shepherd AJ Prior studies have emphasized the role of inflammation in the response to injury and muscle regeneration, but little…
Non-invasive brain stimulation for fibromyalgia: current trends and future perspectives.
Source: Front Neurosci 2023; 17. doi: 10.3389/fnins.2023.1288765Authors: Zhang JH, Liang J, Yang ZW Fibromyalgia, a common and enduring pain disorder, ranks as the second most prevalent rheumatic disease after osteoarthritis. Recent years have witnessed successful treatment using non-invasive brain stimulation. Transcranial magnetic stimulation, transcranial direct…
Omentin-1 ameliorates the progress of osteoarthritis by promoting IL-4-dependent anti-inflammatory responses and M2 macrophage polarization.
Source: Int J Biol Sci 2023; 19(16). doi: 10.7150/ijbs.86701Authors: Ko CY, Lin YY, Achudhan D, Chang JW, Liu SC, Lai CY, Huang YL, Tsai CH, Fong YC, Chen HT, Lee KT, Huang CC, Chang TK, Tang CH Osteoarthritis (OA) is a prevalent joint disease commonly…
Lessons learned in translating pain knowledge into practice.
Source: Pain Rep 2023 Dec; 8(6). doi: 10.1097/PR9.0000000000001100Authors: Becker J, Effraim PR, Dib-Hajj S, Rittner HL During the past 2 decades, basic research deciphering the underlying mechanisms of nociception and chronic pain was thought to finally step beyond opioids and nonsteroidals and provide patients with…
The role of micro-RNAs in neuropathic pain-a scoping review.
Source: Pain Rep 2023 Dec; 8(6). doi: 10.1097/PR9.0000000000001108Authors: Kovanur Sampath K, Belcher S, Hales J, Thomson OP, Farrell G, Gisselman AS, Katare R, Tumilty S Neuropathic pain can be caused by a lesion or disease of the somatosensory system characterised by pathological neuro-immune alterations. At…
Postoperative pain-related outcomes and perioperative pain management in China: a population-based study.
Source: Lancet Reg Health West Pac 2023 Oct; 39. doi: 10.1016/j.lanwpc.2023.100822Authors: Liu Y, Xiao S, Yang H, Lv X, Hou A, Ma Y, Jiang Y, Duan C, Mi W Postoperative pain poses a significant challenge to the healthcare system and patient satisfaction and is associated…
Developing Measures for and Testing the Theory of Communicative Disenfranchisement (TCD) in the Context of Chronic Pain.
Source: Health Commun 2023 Nov 06; . doi: 10.1080/10410236.2023.2275916Authors: Hintz EA, Tucker RV, Wilson SR The post-positivist articulation of the theory of communicative disenfranchisement (TCD) asserts that people subjected to disenfranchising talk (DT; talk that discredits, silences, and stereotypes) experience proximal consequences (PCs; reduced agency,…
Amelioration of morphine withdrawal syndrome by systemic and intranasal administration of mesenchymal stem cell-derived secretome in preclinical models of morphine dependence.
Source: CNS Neurosci Ther 2023 Nov 06; . doi: 10.1111/cns.14517Authors: Quezada M, Ponce C, Berríos-Cárcamo P, Santapau D, Gallardo J, De Gregorio C, Quintanilla ME, Morales P, Ezquer M, Herrera-Marschitz M, Israel Y, Andrés-Herrera P, Hipólito L, Ezquer F Morphine is an opiate commonly used…
Increased glymphatic system activity in migraine chronification by diffusion tensor image analysis along the perivascular space.
Source: J Headache Pain 2023 Nov 06; 24(1). doi: 10.1186/s10194-023-01673-3Authors: Zhang X, Wang W, Bai X, Zhang X, Yuan Z, Jiao B, Zhang Y, Li Z, Zhang P, Tang H, Zhang Y, Yu X, Bai R, Wang Y, Sui B Preliminary evidence suggests that several…
[Migraine and mitochondrial diseases : Energy deficit in the brain].
Source: Schmerz 2023 Nov 03; . doi: 10.1007/s00482-023-00764-zAuthors: Hämmerl L, Kraya T Mitochondrial diseases are complex metabolic disorders caused by genetic mutations and lead to impaired energy production in the mitochondria of cells. The clinical spectrum ranges from severe multiorgan involvement in early childhood to…
Upregulation of Calhm2 in the anterior cingulate cortex contributes to the maintenance of bilateral mechanical allodynia and comorbid anxiety symptoms in inflammatory pain conditions.
Source: Brain Res Bull 2023 Nov 03; . doi: 10.1016/j.brainresbull.2023.110808Authors: Li X, Xiong M, Gao Y, Xu X, Ke C Peripheral inflammation-induced chronic pain tends to evoke concomitant anxiety disorders. It’s common knowledge that the anterior cingulate cortex (ACC) plays a vital role in maintaining…
Mitochondrial dysfunction: a new molecular mechanism of intervertebral disc degeneration.
Source: Inflamm Res 2023 Nov 05; . doi: 10.1007/s00011-023-01813-0Authors: Song C, Xu Y, Peng Q, Chen R, Zhou D, Cheng K, Cai W, Liu T, Huang C, Fu Z, Wei C, Liu Z Intervertebral disc degeneration (IVDD) is a chronic degenerative orthopedic illness that causes…