November 14-20, 2025
Showing 1-25 of 31.
Histone lactylation contributes to neuropathic pain by facilitating m(6)A reader protein IGF2BP2 expression in DRG sensory neurons
Source: The Journal of neuroscience : the official journal of the Society for Neuroscience Authors: Qi-Hui Wang, Shan Xie, Ke-Hui Yang, Yu-Xi Guo, Hui-Ying Huang, Si-Yuan Li, Ya Liu, Ying Zeng, Can Wang, Yue Huang, Li Yang, Hong-Jun Wang, Ling-Yun Hao, Zhi-Qiang Pan, Publication Date:…
Corneal nerve loss measured by corneal confocal microscopy predicts pain severity in Parkinson’s disease
Source: Neurobiology of disease Authors: Peixiao Yin, Chenyang Guan, Xuebin Niu, Liying Yang, Min Xu, Xi Wang, ZiXuan Zhang, JinYu Li, YuNing Liu, Zihao Lin, Guiyun Cui, Kun Zan, Chuanying Xu, Publication Date: Wed, 19 Nov 2025 06:00:00 -0500 Neurobiol Dis. 2025 Nov 17:107197. doi:…
Noradrenergic alpha(2) Receptor Modulates Cav2.2-Mediated Nociception in Parkinson’s Disease Through Spinal Neuro-glial Network
Source: Molecular neurobiology Authors: Shouye Cui, Yuan He, Yueting Gu, Hanjing Wu, Dequan Guo, Limei Zhang, Publication Date: Wed, 19 Nov 2025 06:00:00 -0500 Mol Neurobiol. 2025 Nov 19;63(1):86. doi: 10.1007/s12035-025-05340-3. ABSTRACT Parkinson’s disease (PD)-associated pain, linked to locus coeruleus noradrenergic (LC-NE) degeneration, involves spinal…
Mitochondria relay cholesterol signal exacerbates osteoarthritis in mice
Source: Nature communications Authors: Yiyang Ma, Yidan Pang, Chenglong Liu, Yuchen Tian, Kaiwen Zheng, Meng Yao, Xiaofeng Liu, Ruomu Cao, Yiwei Zhao, Zhikai Zheng, Weitao Jia, Daoyu Zhu, Hao Peng, Dajiang Du, Xinhua Qu, Chuan-Ju Liu, Pei Yang, Yigang Huang, Changqing Zhang, Junjie Gao, Publication…
Narrative review of the scientific and methodological explanations for 101 mechanisms of opioid tolerance
Source: Pain reports Authors: Michael M Morgan, Erin N Bobeck, Publication Date: Wed, 19 Nov 2025 06:00:00 -0500 Pain Rep. 2025 Nov 14;10(6):e1357. doi: 10.1097/PR9.0000000000001357. eCollection 2025 Dec. ABSTRACT Opioids such as morphine and fentanyl are widely prescribed treatments for pain. Unfortunately, opioid use is…
Efficacy and safety of the Ca(v)2.2 blocker Ziconotide in pain: a meta-analysis and systematic review
Source: Pain reports Authors: Javier Picañol, Aida Castellanos, Francesco Sartori, Xavier Gasull, David Soto, Publication Date: Wed, 19 Nov 2025 06:00:00 -0500 Pain Rep. 2025 Nov 14;10(6):e1363. doi: 10.1097/PR9.0000000000001363. eCollection 2025 Dec. ABSTRACT Chronic pain remains a significant clinical challenge, especially in refractory cases. Ziconotide,…
Spatial transcriptomic alterations of the dorsal horn in dogs with neuropathic pain
Source: Pain reports Authors: Tenna Remler Pedersen, Jørgen Steen Agerholm, Clare Rusbridge, Nanna Brix Finnerup, Fernando Constantino-Casas, Merete Fredholm, Mette Berendt, Jens Randel Nyengaard, Publication Date: Wed, 19 Nov 2025 06:00:00 -0500 Pain Rep. 2025 Nov 14;10(6):e1360. doi: 10.1097/PR9.0000000000001360. eCollection 2025 Dec. ABSTRACT INTRODUCTION: Microglia…
Comparative study evaluating the efficacy of duloxetine, gabapentin, and lacosamide on oxaliplatin-induced peripheral neuropathy
Source: Pain reports Authors: Sally Said Tantawy, Osama Mohamed Ibrahim, Sahar Mohamed El-Haggar, Mohamed Abouelfetouh Shehata, Publication Date: Wed, 19 Nov 2025 06:00:00 -0500 Pain Rep. 2025 Nov 14;10(6):e1366. doi: 10.1097/PR9.0000000000001366. eCollection 2025 Dec. ABSTRACT INTRODUCTION: Peripheral neuropathic pain limits oxaliplatin use and negatively impacts…
Controllability changes pain perception by increasing the precision of expectations
Source: Nature communications Authors: Marie Habermann, Christian Büchel, Publication Date: Tue, 18 Nov 2025 06:00:00 -0500 Nat Commun. 2025 Nov 18;16(1):10113. doi: 10.1038/s41467-025-66038-7. ABSTRACT The ability to exert control over an intensely unpleasant experience, such as pain, can modulate its perception. It is often assumed…
Alleviation of negative emotional and pain responses through amygdala-hypothalamic social circuit activation
Source: Proceedings of the National Academy of Sciences of the United States of America Authors: Xinqi Lu, Guohua Chen, Weizhe Hong, Shuaishuai Hu, Rongfeng K Hu, Publication Date: Tue, 18 Nov 2025 06:00:00 -0500 Proc Natl Acad Sci U S A. 2025 Nov 25;122(47):e2511106122. doi:…
EXPRESS: Circulating microRNAs Associated with Acupuncture-Induced Substance P Reduction in Chronic Neck Pain: Evidence for a Neuroplasticity Mechanism
Source: Molecular pain Authors: Seung-Nam Kim, Publication Date: Tue, 18 Nov 2025 06:00:00 -0500 Mol Pain. 2025 Nov 18:17448069251401661. doi: 10.1177/17448069251401661. Online ahead of print. ABSTRACT BACKGROUND: Acupuncture effectively reduces chronic neck pain and plasma Substance P (SP) levels, but upstream molecular mechanisms remain unknown….
The role of dopaminergic signalling from physiology to neuroprotection in acute and chronic disorders
Source: Neurobiology of disease Authors: Martina Di Nunzio, Maria Lidia Mignogna, Marco Bacigaluppi, Paola Panina-Bordignon, Paolo Ragonese, Luca Muzio, Vincenzo Summa, Gianvito Martino, Publication Date: Mon, 17 Nov 2025 06:00:00 -0500 Neurobiol Dis. 2025 Nov 15:107194. doi: 10.1016/j.nbd.2025.107194. Online ahead of print. ABSTRACT The dopaminergic…
Peripheral Neuropathy: A Review
Source: JAMA Authors: Michelle L Mauermann, Nathan P Staff, Publication Date: Mon, 17 Nov 2025 06:00:00 -0500 JAMA. 2025 Nov 17. doi: 10.1001/jama.2025.19400. Online ahead of print. ABSTRACT IMPORTANCE: Peripheral neuropathy, defined as damage to peripheral nerves, affects approximately 1% of adults worldwide. More than…
Real-world effectiveness and safety of galcanezumab for the treatment of migraine: A systematic review and meta-analysis
Source: Headache Authors: Jaime Fernández-Bravo-Rodrigo, Carlos Pascual-Morena, Alicia Saz-Lara, Irene Martínez-García, Carla Geovanna Lever-Megina, Silvana Patiño-Cardona, Amparo Flor-García, Iván Cavero-Redondo, Publication Date: Mon, 17 Nov 2025 06:00:00 -0500 Headache. 2025 Nov 17. doi: 10.1111/head.70003. Online ahead of print. ABSTRACT OBJECTIVE: This study aimed to summarize…
Adding Insult to Injury: Examining the Influence of Peer Pain-Related Stigma on Daily Functioning in Youth with Chronic Musculoskeletal Pain
Source: The journal of pain Authors: Felicitas A Huber, Kathryn A Thompson-Phillips, Emily O Wakefield, Parker A Kell, Tolulope Adetayo, Pavithra A Thomas, Burel R Goodin, Publication Date: Sun, 16 Nov 2025 06:00:00 -0500 J Pain. 2025 Nov 14:105602. doi: 10.1016/j.jpain.2025.105602. Online ahead of print….
GsMTx-4 reduces mechanical allodynia in a model of schwannomatosis-related pain
Source: The journal of pain Authors: Carson Gutierrez, Randy Rubright, Kimberly Laskie Ostrow, Publication Date: Sun, 16 Nov 2025 06:00:00 -0500 J Pain. 2025 Nov 14;38:105597. doi: 10.1016/j.jpain.2025.105597. Online ahead of print. ABSTRACT Patients with schwannomatosis (SWN) develop multiple tumors, called schwannomas, along peripheral nerves,…
Pain rating variability and response to treatment in osteoarthritis clinical trials
Source: The journal of pain Authors: Camila Bonin Pinto, Joana Barroso, Thomas J Schnitzer, Publication Date: Sun, 16 Nov 2025 06:00:00 -0500 J Pain. 2025 Nov 14:105601. doi: 10.1016/j.jpain.2025.105601. Online ahead of print. ABSTRACT Despite recognition that osteoarthritis (OA) pain is dynamic, most clinical trials…
Distress is positively associated with induced secondary hyperalgesia in people with suppressed HIV
Source: The journal of pain Authors: Luyanduthando Mqadi, Gillian J Bedwell, Ncumisa Msolo, Gwendoline Arendse, Maia Lesosky, Peter R Kamerman, Mark R Hutchinson, Andrew Schrepf, Robert R Edwards, John A Joska, Romy Parker, Victoria J Madden, Publication Date: Sun, 16 Nov 2025 06:00:00 -0500 J…
The body sends a signal: Perspectives on interoception
Source: PLoS biology Authors: Lucas K Smith, PLOS Biology staff editors, Publication Date: Fri, 14 Nov 2025 06:00:00 -0500 PLoS Biol. 2025 Nov 14;23(11):e3003517. doi: 10.1371/journal.pbio.3003517. eCollection 2025 Nov. ABSTRACT Research into brain-body communication is being reinvigorated as the field unites under the umbrella of…
No differences in subcortical volume between people with and without migraine: A REFORM study
Source: Headache Authors: Basit Ali Chaudhry, Rune Häckert Christensen, Håkan Ashina, Haidar Muhsen Al-Khazali, Tariq Mohammad Amin, Messoud Ashina, Faisal Mohammad Amin, Publication Date: Fri, 14 Nov 2025 06:00:00 -0500 Headache. 2025 Nov 14. doi: 10.1111/head.70001. Online ahead of print. ABSTRACT OBJECTIVES/BACKGROUND: To determine whether…
Psychosocial factors as predictors of headache chronification: A systematic review and meta-analysis of longitudinal studies
Source: Headache Authors: Cornel H M Tol, Corine M Visscher, Annemarie C van der Wal, Naichuan Su, Hedwig A van der Meer, Publication Date: Fri, 14 Nov 2025 06:00:00 -0500 Headache. 2025 Nov 14. doi: 10.1111/head.15096. Online ahead of print. ABSTRACT OBJECTIVES/BACKGROUND: This study aimed…
TIM3 attenuates morphine antinociceptive tolerance and microglial neuroinflammation by suppressing the TRAF6/NF-κB pathway in male mice
Source: Neuropharmacology Authors: Huan Yang, Tong Shen, Zhi Qi, Zhong Yang, Mengyu Zhang, Jinhong Jiang, Zhuo Sun, Chen Lu, Publication Date: Thu, 21 Aug 2025 06:00:00 -0400 Neuropharmacology. 2025 Nov 15;279:110638. doi: 10.1016/j.neuropharm.2025.110638. Epub 2025 Aug 19. ABSTRACT Chronic morphine administration often leads to the…
Neuropathic pain caused contextual fear generalization by reducing RIN1 expression in dorsal hippocampal CA1 pyramidal neurons
Source: Neuropharmacology Authors: Qi Zhang, Yu-Bo Gao, Juan Li, Hu-Hu Bai, Xu Yang, Jia-Ning Dang, Xiao-Xue Liu, Xue Bai, Xian Yang, Zhan-Wei Suo, Xiao-Dong Hu, Publication Date: Wed, 20 Aug 2025 06:00:00 -0400 Neuropharmacology. 2025 Nov 15;279:110644. doi: 10.1016/j.neuropharm.2025.110644. Epub 2025 Aug 18. ABSTRACT Conditioned…
Temporal Changes in PROMs Improvement and Recovery Kinetics Following Transforaminal Endoscopic Lumbar Discectomy
Source: Spine Authors: Eric Zhao, Adin Ehrlich, Arsen Omurzakov, Tomoyuki Asada, Quante Singleton, Luis Colon, Stephane Owusu-Sarpong, Farah Musharbash, Sereen Halayqeh, Adrian Lui, Andrea Pezzi, Kasra Araghi, Tejas Subramanian, Eric Mai, Annika Heuer, Nishtha Singh, Olivia C Tuma, Atahan Durbas, Tarek Harhash, Sheeraz Qureshi, Sravisht…
Hip, Abdomen, and Paraspinal Muscle Morphologies and Their Correlation With Pain and Disability in Degenerative Lumbar Scoliosis Patients
Source: Spine Authors: Jong Min Lee, Doo-Hyung Lee, Nam-Su Chung, Hee-Woong Chung, Jeong-Hyun Koh, Youngsoo Yoon, Han-Dong Lee, Publication Date: Wed, 16 Apr 2025 06:00:00 -0400 Spine (Phila Pa 1976). 2025 Nov 15;50(22):1589-1596. doi: 10.1097/BRS.0000000000005362. Epub 2025 Apr 16. ABSTRACT DESIGN: Single-center, cross-sectional study. OBJECTIVE:…