May 27 - June 2, 2023
Showing 1-25 of 119.
Gate control of sensory neurotransmission in peripheral ganglia by proprioceptive sensory neurons.
Source: Brain 2023 May 30;. doi: 10.1093/brain/awad182 Authors: Fuller AM, Luiz A, Tian N, Arcangeletti M, Iseppon F, Sexton JE, Millet Q, Caxaria S, Ketabi N, Celik P, Wood JN, Sikandar S Melzak and Wall’s gate control theory proposed that innocuous input into the dorsal…
Principles of nociceptive coding in the anterior cingulate cortex.
Source: Proc Natl Acad Sci U S A 2023 Jun 06; 120(23). doi: 10.1073/pnas.2212394120 Authors: Acuña MA, Kasanetz F, De Luna P, Falkowska M, Nevian T The perception of pain is a multidimensional sensory and emotional/affective experience arising from distributed brain activity. However, the involved…
Feasibility of high-dose tadalafil and effects on insulin resistance in well-controlled patients with type 2 diabetes (MAKROTAD): a single-centre, double-blind, randomised, placebo-controlled, cross-over phase 2 trial.
Source: EClinicalMedicine 2023 May; 59. doi: 10.1016/j.eclinm.2023.101985Authors: Fryk E, Rodrigues Silva VR, Bauzá-Thorbrügge M, Schmelz M, Gan LM, Strindberg L, Jansson PA Phosphodiesterase-5 inhibitors exert positive vascular and metabolic effects in type 2 diabetes (T2D), but the effect on insulin resistance in T2D is unclear….
Upadacitinib for moderate-to-severe atopic dermatitis: stratified analysis from three randomized phase 3 trials by key baseline characteristics.
Source: J Eur Acad Dermatol Venereol 2023 May 29; . doi: 10.1111/jdv.19232Authors: Thyssen JP, Thaçi D, Bieber T, Gooderham M, de Bruin-Weller M, Soong W, Kabashima K, Barbarot S, Luna PC, Xu J, Hu X, Liu Y, Raymundo EM, Calimlim BM, Nduaka C, Gamelli A,…
Prevalence and predictors of suicidality among adults initiating office-based buprenorphine.
Source: Addict Sci Clin Pract 2023 Jun 01; 18(1). doi: 10.1186/s13722-023-00393-yAuthors: Lent MR, Dugosh KL, Hurstak E, Callahan HR, Mazur K Individuals who have substance use disorders may have an elevated risk of suicidality. This study sought to examine the prevalence of, and identify factors…
Migraine with and without aura in relation to the menstrual cycle and other hormonal milestones: A prospective cohort study.
Source: Cephalalgia 2023 Jun; 43(6). doi: 10.1177/03331024231164322Authors: Verhagen IE, van der Arend BW, van Casteren DS, Thiermann NJ, Tange E, MaassenVanDenBrink A, Terwindt GM Previous studies showed that the perimenstrual window is associated with an increased susceptibility to migraine attacks without aura, but had conflicting…
Reversal of Neuralgia Effect of Beta Carotene in Streptozotocin-Associated Diabetic Neuropathic Pain in Female Zebrafish via Matrix Metalloprotease-13 Inhibition.
Source: Pharmaceuticals (Basel) 2023 Jan 22; 16(2). doi: 10.3390/ph16020157Authors: Paramakrishnan N, Chavan L, Lim KG, Paramaswaran Y, Muthuraman A Beta carotene is a natural anti-oxidant agent, and it inhibits the matrix metalloprotease (MMP) activity. Diabetic neuropathic pain (DNP) is produced by cellular oxidative stress. The…
Population Pharmacokinetic Modeling of Zaltoprofen in Healthy Adults: Exploring the Dosage Regimen.
Source: Pharmaceuticals (Basel) 2023 Jan 22; 16(2). doi: 10.3390/ph16020161Authors: Jang JH, Jeong SH, Lee YB Zaltoprofen is a drug used for various pain and inflammatory diseases. Scientific and quantitative dosage regimen studies regarding its clinical application are scarce. This study aimed to discover effective covariates…
Pharmacological Profiling of K Channel Modulators: An Outlook for New Treatment Opportunities for Migraine.
Source: Pharmaceuticals (Basel) 2023 Feb 01; 16(2). doi: 10.3390/ph16020225Authors: Dyhring T, Jansen-Olesen I, Christophersen P, Olesen J Migraine is a highly disabling pain disorder with huge socioeconomic and personal costs. It is genetically heterogenous leading to variability in response to current treatments and frequent lack…
Contribution of immune cells to cancer-related neuropathic pain: An updated review.
Source: Mol Pain 2023 May 31; . doi: 10.1177/17448069231182235Authors: Ma H, Pan Z, Lai B, Li M, Wang J Given that the incidence of cancer is dramatically increasing nowadays, cancer-related neuropathic pain including tumor-related and therapy-related pain gradually attracts more attention from researchers, which basically…
Measures of sleep disturbance are not routinely captured in trials for chronic low back pain: a systematic scoping review of 282 trials.
Source: J Clin Sleep Med 2023 Jun 01; . doi: 10.5664/jcsm.10672Authors: Neilson BD, Dickerson C, Young JL, Shepherd MH, Rhon DI To investigate the extent to which sleep measures are reported in intervention trials for chronic low back pain. Pubmed ID: https://pubmed.ncbi.nlm.nih.gov/37259893/
Dorsal root ganglion stimulation for chemotherapy-induced peripheral neuropathy.
Source: Pain Pract 2023 Jun 01; . doi: 10.1111/papr.13259Authors: Ege E, Briggi D, Mach S, Huh BK, Javed S Chemotherapy-induced peripheral neuropathy (CIPN) is a common consequence of cancer treatment that can be persistent and difficult to manage. Dorsal root ganglion stimulation (DRG-S) is a…
Automated Patch Clamp Screening of Amiloride and 5-,-Hexamethyleneamiloride Analogs Identifies 6-Iodoamiloride as a Potent Acid-Sensing Ion Channel Inhibitor.
Source: Mol Pharm 2023 Jun 01; . doi: 10.1021/acs.molpharmaceut.2c01083Authors: Finol-Urdaneta RK, McArthur JR, Aboelela A, Bujaroski RS, Majed H, Rangel A, Adams DJ, Ranson M, Kelso MJ, Buckley BJ Acid-sensing ion channels (ASICs) are transmembrane sensors of extracellular acidosis and potential drug targets in several…
Collagen mimetic peptide repair of the corneal nerve bed in a mouse model of dry eye disease.
Source: Front Neurosci 2023; 17. doi: 10.3389/fnins.2023.1148950Authors: Wareham LK, Holden JM, Bossardet OL, Baratta RO, Del Buono BJ, Schlumpf E, Calkins DJ The intraepithelial sub-basal nerve plexus of the cornea is characterized by a central swirl of nerve processes that terminate between the apical cells…
The Effects and Potential Mechanisms of Moxibustion for Rheumatoid Arthritis-Related Pain: A Randomized, Controlled Trial.
Source: J Pain Res 2023; 16. doi: 10.2147/JPR.S408814Authors: Liao C, Tao S, Xiong Y, Dai J, Bai Y, Wang X, Li Y, Wu P To investigate the effects of moxibustion in relieving pain, and other clinical symptoms for patients with rheumatoid arthritis (RA), and explore…
Calcitonin in the Treatment of Phantom Limb Pain: A Systematic Review.
Source: CNS Drugs 2023 Jun 01; . doi: 10.1007/s40263-023-01010-xAuthors: Neumüller J, Lang-Illievich K, Brenna CTA, Klivinyi C, Bornemann-Cimenti H Phantom limb pain (PLP) refers to pain perceived in a part of the body removed by amputation or trauma. Despite the high prevalence of PLP following…
Posttraumatic stress and distress tolerance in relation to opioid misuse and dependence among trauma-exposed adults with chronic pain.
Source: Exp Clin Psychopharmacol 2023 Jun 01; . doi: 10.1037/pha0000661Authors: Fogle BM, Kabel K, Shepherd JM, Rogers AH, Vujanovic AA, Zvolensky MJ Posttraumatic stress symptoms have been associated with opioid misuse and dependence among adults with chronic pain. Lower levels of perceived distress tolerance (i.e.,…
The efficacy of manual therapy on HRV in those with long-standing neck pain: a systematic review.
Source: Scand J Pain 2023 Jun 01; . doi: 10.1515/sjpain-2023-0006Authors: Harper B, Price P, Steele M Long-standing neck pain (LNP) is a clinical condition frequently encountered in the physical therapy clinic. LNP is a complex, multifactorial condition affecting multiple body systems including the autonomic nervous…
QuickStats: Percentage* of Adults Aged ≥18 Years Who Have Been Bothered a Lot by Headache or Migraine in the Past 3 Months, by Sex and Age Group – National Health Interview Survey, 2021.
Source: MMWR Morb Mortal Wkly Rep 2023 Jun 02; 72(22). doi: 10.15585/mmwr.7222a6Authors: Pubmed ID: https://pubmed.ncbi.nlm.nih.gov/37262002/
The top 100 most cited articles on Acupuncture in the last 20 years: a Bibliometric Analysis.
Source: Complement Med Res 2023 Jun 01; . doi: 10.1159/000530778Authors: Ma Y, Li B, Cui Y, Zhang Z, Jiang S, Yan X, He J, Du Y Acupuncture has gained increasing international attention in recent decades. The act of incorporating acupuncture treatment into the routine treatment…
Guidelines for the management of trigeminal neuralgia.
Source: Cleve Clin J Med 2023 Jun 01; 90(6). doi: 10.3949/ccjm.90a.22052Authors: Chong MS, Bahra A, Zakrzewska JM Guidelines for the diagnosis and treatment of patients with trigeminal neuralgia (TN) advocate for a multidisciplinary team approach to improve the care of patients with acute and chronic…
The glycine receptor alpha 3 subunit mRNA expression shows sex-dependent differences in the adult mouse brain.
Source: BMC Neurosci 2023 Jun 01; 24(1). doi: 10.1186/s12868-023-00800-9Authors: Ceder MM, Weman HM, Johansson E, Henriksson K, Magnusson KA, Roman E, Lagerström MC The glycinergic system plays an important inhibitory role in the mouse central nervous system, where glycine controls the excitability of spinal itch-…
Identification and validation of biomarkers related to Th1 cell infiltration in neuropathic pain.
Source: J Inflamm (Lond) 2023 Jun 01; 20(1). doi: 10.1186/s12950-023-00343-0Authors: Zhang X, Cheng J, Deng Y, Guo C, Cao Y, Wang S, Zhou C, Lin Z, Tang S, Zhou J Neuropathic pain (NP) is a widespread chronic pain with a prevalence of 6.9-10% in the…
Electroacupuncture prevents astrocyte atrophy to alleviate depression.
Source: Cell Death Dis 2023 May 29; 14(5). doi: 10.1038/s41419-023-05839-4Authors: Lin SS, Zhou B, Chen BJ, Jiang RT, Li B, Illes P, Semyanov A, Tang Y, Verkhratsky A Astrocyte atrophy is the main histopathological hallmark of major depressive disorder (MDD) in humans and in animal…
Activation of neurons and satellite glial cells in the DRG produces morphine-induced hyperalgesia.
Source: Mol Pain 2023 May 30; . doi: 10.1177/17448069231181973Authors: Yamakita S, Fujita D, Sudo K, Ishikawa D, Kushimoto K, Horii Y, Amaya F Activation of neurons and glial cells in the dorsal root ganglion is one of the key mechanisms for the development of hyperalgesia….