May 20-26, 2023

Source: Neuron 2023 May 16;. doi: 10.1016/j.neuron.2023.04.032 Authors: Pan Q, Guo SS, Chen M, Su XY, Gao ZL, Wang Q, Xu TL, Liu MG, Hu J Pain and itch are two closely related but essentially distinct sensations that elicit different behavioral responses. However, it remains…

Source: Nat Commun 2023 May 24; 14(1). doi: 10.1038/s41467-023-38798-7 Authors: Ziegler K, Folkard R, Gonzalez AJ, Burghardt J, Antharvedi-Goda S, Martin-Cortecero J, Isaías-Camacho E, Kaushalya S, Tan LL, Kuner T, Acuna C, Kuner R, Mease RA, Groh A The primary somatosensory cortex (S1) is a…

Source: Nat Neurosci 2023 May 22;. doi: 10.1038/s41593-023-01338-z Authors: Shirvalkar P, Prosky J, Chin G, Ahmadipour P, Sani OG, Desai M, Schmitgen A, Dawes H, Shanechi MM, Starr PA, Chang EF Chronic pain syndromes are often refractory to treatment and cause substantial suffering and disability….

Source: Sci Adv 2023 May 19; 9(20). doi: 10.1126/sciadv.adg2819 Authors: Zhang H, Rodriguez-Hernandez LD, D’Souza AJ, He D, Zain M, Fung SW, Bennett LA, Bonin RP Chronic, pathological pain is a highly debilitating condition that can arise and be maintained through central sensitization. Central sensitization…

Source: Ann Rheum Dis 2023 May 22; . doi: 10.1136/ard-2022-223759Authors: Takeuchi T, Tanaka S, Murata M, Tanaka Y To examine the efficacy and safety of TAS5315, an irreversible covalent Bruton’s tyrosine kinase inhibitor, in Japanese patients with rheumatoid arthritis (RA) refractory to methotrexate. Pubmed ID: https://pubmed.ncbi.nlm.nih.gov/37217273/

Source: Am J Clin Dermatol 2023 May 22; . doi: 10.1007/s40257-023-00785-5Authors: Simpson EL, Silverberg JI, Thyssen JP, Viguier M, Thaçi D, de Bruin-Weller M, Weidinger S, Chan G, DiBonaventura M, Biswas P, Feeney C, Koulias C, Cork MJ Traditional systemic immunosuppressants and advanced therapies improve…

Source: Pain Med 2023 May 23; . doi: 10.1093/pm/pnad070Authors: Maddox T, Sparks C, Oldstone L, Maddox R, Ffrench K, Garcia H, Krishnamurthy P, Okhotin D, Garcia LM, Birckhead BJ, Sackman J, Mackey I, Louis R, Salmasi V, Oyao A, Darnall BD ClinicalTrials.gov NCT04415177; https://clinicaltrials.gov/ct2/show/NCT04415177. Pubmed…

Source: Lancet Neurol 2023 Jun; 22(6). doi: 10.1016/S1474-4422(23)00126-6Authors: Yu S, Kim BK, Guo A, Kim MH, Zhang M, Wang Z, Liu J, Moon HS, Tan G, Yang Q, McGrath D, Hanna M, Stock DA, Gao Y, Croop R, Lu Z No acute treatments targeting calcitonin…

Source: J Headache Pain 2023 May 25; 24(1). doi: 10.1186/s10194-023-01599-wAuthors: Rasmussen NB, Deligianni C, Christensen CE, Karlsson WK, Al-Khazali HM, Van de Casteele T, Granhall C, Amin FM, Ashina M Pituitary adenylate cyclase-activating polypeptide (PACAP), structurally related to vasoactive intestinal peptide (VIP), is one of…

Source: Cephalalgia 2023 May; 43(5). doi: 10.1177/03331024231178239Authors: Abu-Arafeh I, Hershey AD, Diener HC, Tassorelli C Recent experience in designing and running clinical trials on new medications for the prevention of migraine in children and adolescents highlighted the need for revision of the 1st edition of…

Source: Cephalalgia 2023 May; 43(5). doi: 10.1177/03331024231178218Authors: Park CG, Na HY, Park DE, Kim HY, Chu MK Serum histamine, immunoglobulin E, and tryptase are markers of allergic diseases. Despite the reported association between migraine and allergic diseases, differences in these marker levels between episodic and…

Source: Mol Pain 2023; 19. doi: 10.1177/17448069231178741Authors: Ren B, Zhang J, Yang X, Sun D, Sheng D, Fang Q, Ji Z Kappa-opioid receptor (KOR) agonists are known for having opposite and/or different effects compared with Mu-opioid receptor (MOR) agonists. This study is aimed at clarifying…

Source: Brain Behav 2023 May 24; . doi: 10.1002/brb3.3005Authors: Ellerbroek H, Hanssen I, Lathouwers K, Cillessen L, Dekkers S, Veldman SE, van den Heuvel SAS, Speckens AEM, Schellekens AFA Mindfulness-based interventions have a positive impact on pain, craving, and well-being in both patients with chronic…

Source: Pain 2023 Apr 27; . doi: 10.1097/j.pain.0000000000002909Authors: Kmiecik MJ, Tu FF, Clauw DJ, Hellman KM Multimodal hypersensitivity (MMH)-greater sensitivity across multiple sensory modalities (eg, light, sound, temperature, pressure)-is associated with the development of chronic pain. However, previous MMH studies are restricted given their reliance…

Source: Mol Pain 2023; 19. doi: 10.1177/17448069231179011Authors: Zhuo M Synaptic plasticity such as Long-term potentiation (LTP) is a key mechanism for learning in central synapses including the cortex. There are two least two major forms of LTPs: presynaptic LTP and postsynaptic LTP. For postsynaptic LTP,…

Source: Neurosurgery 2023 May 25; . doi: 10.1227/neu.0000000000002548Authors: Dehdashtian A, Timek JH, Svientek SR, Risch MJ, Bratley JV, Riegger AE, Kung TA, Cederna PS, Kemp SWP Treating neuroma pain is a clinical challenge. Identification of sex-specific nociceptive pathways allows a more individualized pain management. The…

Source: Drugs 2023 May 25; . doi: 10.1007/s40265-023-01885-6Authors: Dhillon S Zavegepant is a third generation, small-molecule, calcitonin gene-related peptide (CGRP) receptor antagonist being developed by Pfizer, under a license from Bristol-Myers Squibb, for the prevention and treatment of chronic and episodic migraine. In March 2023,…

Source: Mol Neurobiol 2023 May 25; . doi: 10.1007/s12035-023-03386-9Authors: Liu L, Zhao Y, An W, Zhao M, Ding N, Liu H, Ge N, Wen J, Zhang X, Zu S, Sun W Mechanical sensing Piezo2 channel in primary sensory neurons has been shown contribute to mechanical…

Source: Eur J Neurol 2023 May 25; . doi: 10.1111/ene.15892Authors: Mason I, Renée J, Marples I, McWhirter L, Carson A, Stone J, Hoeritzauer I Chronic pain is a common comorbidity in those with functional neurological disorder (FND), however the prevalence and characteristics of FND in…

Source: PLoS One 2023; 18(5). doi: 10.1371/journal.pone.0285975Authors: Oliveira AMB, Teixeira DSDC, Menezes FDS, Marques AP, Duarte YAO, Casarotto RA We investigated the impact of socioeconomic inequalities on chronic pain of older adults according to sex. Pubmed ID: https://pubmed.ncbi.nlm.nih.gov/37228121/

Source: Digit Health 2023; 9. doi: 10.1177/20552076231176114Authors: Fruchart M, El Idrissi F, Lamer A, Belarbi K, Lemdani M, Zitouni D, Guinhouya BC Endometriosis is a complex full-body inflammation disease with an average time to diagnosis of 7-10 years. Social networks give opportunity to patient to…

Source: Front Pain Res (Lausanne) 2023; 4. doi: 10.3389/fpain.2023.1177070Authors: Zmudzki F, Smeets RJEM Chronic musculoskeletal pain is a prevalent condition impacting around 20% of people globally; resulting in patients living with pain, fatigue, restricted social and employment capacity, and reduced quality of life. Interdisciplinary multimodal…

Source: J Pain Res 2023; 16. doi: 10.2147/JPR.S409120Authors: Zhu D, Xu W, Mao Q, Zhong G, Chen R, Jiao L Acupuncture therapy is a unique technology created by the working people in ancient China. It is popular all over the world for its safety, effectiveness…

Source: J Pain Res 2023; 16. doi: 10.2147/JPR.S403715Authors: Burkey AR, Chen J, Argoff CE, Edgar DR, Petersen EA Painful peripheral neuropathy (PPN) is a debilitating condition with varied etiologies. Spinal cord stimulation (SCS) is increasingly used when conservative treatments fail to provide adequate pain relief….

Source: Am J Manag Care 2023 May; 29(5). doi: 10.37765/ajmc.2023.89356Authors: Ukhanova M, Voss RW, Marino M, Huguet N, Bailey SR, Hartung DM, O’Malley J, Chamine I, Muench J One in 5 people in the United States lives with chronic pain. Many patients with chronic pain…