March 6-12, 2026
Showing 1-25 of 27.
A genetic architect of opioid responses: Microglial Runx1
Source: Neuron Authors: Dong Dong, Longzhen Cheng, Publication Date: Thu, 05 Mar 2026 06:00:00 -0500 Neuron. 2026 Mar 4;114(5):795-797. doi: 10.1016/j.neuron.2026.01.008. ABSTRACT Why do opioid responses vary greatly among individuals? Leduc-Pessah et al.1 show that the Runx1 transcription factor is a genetic determinant of opioid…
Intestinal interoceptive dysfunction drives age-associated cognitive decline
Source: Nature Authors: Timothy O Cox, Ashwarya S Devason, Alan de Araujo, Sydney Mason, Madhav Subramanian, Andrea F M Salvador, Hélène C Descamps, Junwon Kim, Yixuan Zhu, Lev Litichevskiy, Sunhee Jung, Won-Suk Song, Adrián Cortés-Martín, Nathan T Henderson, Kuei-Pin Huang, Thao Nguyen, Wisath Sae-Lee, Iboro…
Nav1.5 in the dorsal root ganglion plays a crucial role in mechanical hypersensitivity
Source: Brain : a journal of neurology Authors: Chen-Jing Zhang, Mei-Jun Ji, Xiao-Lu Zhou, Shengnan Li, Peng-Fei Xu, Hui Wu, Qing Chen, Jing Zhao, Xin-Zhong Chen, James J Cox, Xue-Long Zhou, Publication Date: Wed, 11 Mar 2026 06:00:00 -0400 Brain. 2026 Mar 11:awaf438. doi: 10.1093/brain/awaf438….
Persistent interferon signaling causes sensory neuron plasticity and pain before and during arthritis
Source: Nature neuroscience Authors: Jie Su, Ming-Dong Zhang, Jussi Kupari, Dongoh Kwak, Laurence Picton, Bingze Xu, Leandro Flores do Nascimento, Yizhou Hu, Alejandro Gonzalez, Dmitry Usoskin, Zhongwei Xu, Marcin Szczot, Abdeljabbar El Manira, Rikard Holmdahl, Patrik Ernfors, Publication Date: Wed, 11 Mar 2026 06:00:00 -0400…
Era of Sugammadex: A Paradigm Shift in Airway Management
Source: Anesthesiology Authors: Carin A Hagberg, Takashi Asai, Thomas Heidegger, Sheila N Myatra, Jaideep J Pandit, Yandong Jiang, Publication Date: Tue, 10 Mar 2026 06:00:00 -0400 Anesthesiology. 2026 Apr 1;144(4):978-997. doi: 10.1097/ALN.0000000000005828. Epub 2026 Mar 10. ABSTRACT Sugammadex reverses the effects of steroidal neuromuscular blocking…
Primary Afferent Inhibition: An Underappreciated Mechanism in Mechanical Pain Control
Source: Anesthesiology Authors: Cyril Rivat, Ru-Rong Ji, Publication Date: Tue, 10 Mar 2026 06:00:00 -0400 Anesthesiology. 2026 Apr 1;144(4):761-763. doi: 10.1097/ALN.0000000000005917. Epub 2026 Mar 10. NO ABSTRACT PMID:41805211 | DOI:10.1097/ALN.0000000000005917 Pubmed ID: pubmed:41805211 Identifiers: pmid:41805211, doi:10.1097/ALN.0000000000005917,
Discovery of an ITK and TRK kinase inhibitor for the potential topical treatment of atopic dermatitis
Source: Nature communications Authors: Jennifer L Duffen, Kimberly K Crouse, Lin Ji, Amy L Brault, Kristen Ford, Jonathan Brooks, Scott A Jelinsky, Yizheng Li, Julia H Shin, Yajuan Zhao, Tatyana Andreyeva, Katherine Hammerman, Christina Arnold, Richard T Sheldon, Jeonifer Garren, Wes LaBarge, Anthony Resek, Jon…
Descending locus coeruleus noradrenergic signaling to spinal astrocyte subset is required for stress-induced mechanical pain hypersensitivity
Source: eLife Authors: Riku Kawanabe-Kobayashi, Sawako Uchiyama, Kohei Yoshihara, Keisuke Koga, Daiki Kojima, Thomas J McHugh, Izuho Hatada, Ko Matsui, Kenji F Tanaka, Makoto Tsuda, Publication Date: Mon, 09 Mar 2026 06:00:00 -0400 Elife. 2026 Mar 9;14:RP104453. doi: 10.7554/eLife.104453. ABSTRACT It is known that stress…
Differential inhibition of the diverse behavioural effects of mu-opioid receptor agonists by progressive receptor depletion
Source: Neuropharmacology Authors: Lauren Brown, Cory Langreck, Frances Hough, Mel Nelson, Stephen J Briddon, J Robert Lane, Jonathan A Javitch, Meritxell Canals, Publication Date: Mon, 09 Mar 2026 06:00:00 -0400 Neuropharmacology. 2026 Mar 7;291:110909. doi: 10.1016/j.neuropharm.2026.110909. Online ahead of print. ABSTRACT Mu-opioid receptor (MOR) agonists…
Macrophages amplify spontaneous activity of damaged sensory neurons in a human co-culture model of neuropathic pain
Source: Brain : a journal of neurology Authors: Paschalina Chrysostomidou, Zoe Hore, Domenico Somma, Julia M Vlachaki Walker, Katy Diallo, Heather F Titterton, Aziza Elmesmari, Lauramariú Schino, Siobhan Adesida, Mariola Kurowska-Stolarska, Franziska Denk, Greg A Weir, Publication Date: Sat, 07 Mar 2026 06:00:00 -0500 Brain….
Author Correction: Leveraging deep single-soma RNA sequencing to explore the neural basis of human somatosensation
Source: Nature neuroscience Authors: Huasheng Yu, Saad S Nagi, Dmitry Usoskin, Yizhou Hu, Jussi Kupari, Otmane Bouchatta, Hanying Yan, Suna Li Cranfill, Mayank Gautam, Yijing Su, You Lu, James Wymer, Max Glanz, Phillip Albrecht, Hongjun Song, Guo-Li Ming, Stephen Prouty, John Seykora, Hao Wu, Minghong…
Acetaminophen (Paracetamol) or Opioid Analgesia Added to Ibuprofen for Children’s Musculoskeletal Injury: Two Randomized Clinical Trials
Source: JAMA Authors: Samina Ali, Terry P Klassen, Patricia Candelaria, Maala Bhatt, Scott Sawyer, Antonia Stang, Maryna Yaskina, Anna Heath, Petros Pechlivanoglou, Martin Offringa, Amy L Drendel, Serena Hickes, Naveen Poonai, KidsCAN PERC Innovative Pediatric Clinical Trials No OUCH Study Team, Publication Date: Thu, 08…
Development of a Central Sensitization Inventory short form using data from twenty-three countries
Source: The journal of pain Authors: Randy Neblett, Jaime Navarrete, Aleksandar Knezevic, Mohammad Madi, Wolnei Caumo, Leo Yl Wang, Wing Yuk Ip, Liam Culmsee-Holm, Casper Nim, Jeroen Kregel, C Paul van Wilgen, Jani Mikkonen, Laurent Pitance, Michel Klute, Paraskevi Bilika, Dibyendunarayan Dhrubaprasad Bid, Alessandro Chiarotto,…
Cross-lagged longitudinal analysis of pain and fear of cancer recurrence in young female survivors of breast and gynaecological cancers
Source: Pain Authors: Louise Sweeney, Lidia Schapira, Sarah Webster, Sam Norton, Laura E Simons, Rona Moss-Morris, Lauren C Heathcote, Publication Date: Mon, 09 Mar 2026 06:00:00 -0400 Pain. 2026 Mar 6. doi: 10.1097/j.pain.0000000000003951. Online ahead of print. ABSTRACT Chronic cancer-related pain affects up to 40%…
Hypnosis in chronic pain: from new hope to emerging standard?
Source: Pain Authors: Rodrigo R N Rizzo, Mark P Jensen, Publication Date: Mon, 09 Mar 2026 06:00:00 -0400 Pain. 2026 Mar 10. doi: 10.1097/j.pain.0000000000003944. Online ahead of print. NO ABSTRACT PMID:41800791 | DOI:10.1097/j.pain.0000000000003944 Pubmed ID: pubmed:41800791 Identifiers: pmid:41800791, doi:10.1097/j.pain.0000000000003944,
A touch-guided neural circuit regulates motivated gnawing to maintain dental alignment
Source: Neuron Authors: Xin-Yu Su, Elizabeth A Ronan, Sienna K Perry, Hankyu Lee, Chia Chun Hor, Mahar Fatima, Xi Yuan Zheng, Jingyao Wang, Siyi Liu, Karin Harumi Uchima Koecklin, Shuhao Wan, Aditi Jha, Peng Li, Wanlu Du, Dawen Cai, Joshua J Emrick, Bo Duan, Publication…
Clinical Insights Into CASPR1 and CASPR1/Contactin-1 Complex Autoimmune Nodopathies
Source: Neurology Authors: Naveen Kumar Paramasivan, Eati Basal, Reghann G LaFrance-Corey, Friederike Antonia Arlt, Christopher J Klein, Grace Swart, Anousha Mozammel, Michelle L Mauermann, P James B Dyck, Sarah E Berini, Janean Engelstad, Robert Bucelli, Paul Magda, Ewa Pniak, Charulatha P Nagar, Cameron D Crockett,…
A Multicenter Analysis of Baseline Patient-Reported Outcome Measures as Predictors of Progression From Spinal Cord Stimulator Trial to Implantation
Source: Neuromodulation : journal of the International Neuromodulation Society Authors: Sebastian Encalada, Matthew A Cascio, Eva Kubrova, Thomas Herrera, Ryan S D’Souza, Jason S Eldrige, Michael D Osborne, Sharima Kanahan-Osman, Sohail Bade, Sahil Bade, Terry Hunt, Justin Schappell, William D Mauck, Stephen M Covington, Tomás…
Claudin 24-A novel enhancer of AMPA receptor fidelity
Source: Science advances Authors: Tobias Strasdeit, Ehsan Amin, Sebastian Obst, Barbara Biermann, Thomas P Newton, Simon Chris Kösters, Marten Schouwink, Sergey Fedotov, Javeria Shaukat, Subhrajit Bhattacharya, Muhammad Aslam, Max Anstötz, Faik Nadi Okka, Oscar Gabriel Sevillano Quispe, Pascal Bouvain, Julia Vedyashkin, Alexander I Sobolevsky, Stephen…
Prevalence and impact of suspected fibromyalgia on disease outcomes and treatment in axial spondyloarthritis: 10-year follow-up data from the DESIR cohort
Source: Annals of the rheumatic diseases Authors: Clementina López-Medina, Sylvie Chevret, Cédric Lukas, Anna Moltó, Maxime Dougados, Publication Date: Sat, 07 Mar 2026 06:00:00 -0500 Ann Rheum Dis. 2026 Mar 6:S0003-4967(26)00081-6. doi: 10.1016/j.ard.2026.02.006. Online ahead of print. ABSTRACT OBJECTIVES: This study aimed to evaluate the…
Biological/targeted synthetic DMARDs do not arrest bone loss in patients with rheumatoid arthritis: a long-term multicenter observational study
Source: Arthritis & rheumatology (Hoboken, N.J.) Authors: Takafumi Aritomi, Koshiro Sonomoto, Shingo Nakayamada, Hiroaki Tanaka, Atsushi Nagayasu, Satoshi Kubo, Ippei Miyagawa, Ayako Yamaguchi, Naoaki Ohkubo, Yasuyuki Todoroki, Yurie Satoh-Kanda, Masanobu Ueno, Ryuichiro Kanda, Yuya Fujita, Masashi Funada, Hidenori Sakai, Satsuki Matsunaga, Hiroaki Tanaka, Masayuki Shinojima,…
Insomnia symptom severity predicts long-term pain intensity and bothersomeness across ICD-11 chronic pain categories: a registry-based cohort study
Source: Scandinavian journal of pain Authors: Live Landmark, Martijn Smits, Egil A Fors, Øyvin Nydal Dahm, Leif Edward Ottesen Kennair, Henrik Børsting Jacobsen, Publication Date: Tue, 10 Mar 2026 06:00:00 -0400 Scand J Pain. 2026 Mar 11;26(1). doi: 10.1515/sjpain-2025-0050. eCollection 2026 Jan 1. ABSTRACT OBJECTIVES:…
Clinically feasible TENS-pressure-cuff paradigm for conditioned pain modulation
Source: Regional anesthesia and pain medicine Authors: Patricia Beltrá, Luis Suso-Martí, Rodrigo Martín-San Agustín, Miguel Delicado-Miralles, Enrique Velasco Serna, Publication Date: Tue, 10 Mar 2026 06:00:00 -0400 Reg Anesth Pain Med. 2026 Mar 10:rapm-2025-107402. doi: 10.1136/rapm-2025-107402. Online ahead of print. ABSTRACT BACKGROUND: Conditioned pain modulation…
Prescriber adherence to treatment guidelines for monoclonal antibodies against Calcitonin Gene-Related Peptide in migraine prophylaxis – a register-based cohort study
Source: The journal of headache and pain Authors: Sofia Nordenmalm, Rickard E Malmström, Sara Freyland, A Ingela M Nilsson Remahl, Karin Wirdefeldt, Isabella Ekheden, Publication Date: Wed, 11 Mar 2026 06:00:00 -0400 J Headache Pain. 2026 Mar 10. doi: 10.1186/s10194-026-02322-1. Online ahead of print. NO…
Anti-CGRP receptor antibodies do not modulate trigeminal pain processing: indication for distinct mechanisms of CGRP pathway blockade
Source: The journal of headache and pain Authors: Kuan-Po Peng, Hauke Basedau, Karl Messlinger, Arne May, Publication Date: Wed, 11 Mar 2026 06:00:00 -0400 J Headache Pain. 2026 Mar 10;27(1):70. doi: 10.1186/s10194-026-02316-z. NO ABSTRACT PMID:41808003 | DOI:10.1186/s10194-026-02316-z Pubmed ID: pubmed:41808003 Identifiers: pmid:41808003, doi:10.1186/s10194-026-02316-z,