March 22-28, 2025
Showing 1-25 of 155.
A pontine center in descending pain control.
Source: Neuron 2025 Mar 20;. doi: 10.1016/j.neuron.2025.02.028 Authors: Li T, Zhou W, Ke J, Chen M, Wang Z, Hayashi L, Su X, Jia W, Huang W, Wang CS, Bengyella K, Yang Y, Hernandez R, Zhang Y, Song X, Xu T, Huang T, Liu Y Pain…
Enteric neuronal Piezo1 maintains mechanical and immunological homeostasis by sensing force.
Source: Cell 2025 Mar 20;. doi: 10.1016/j.cell.2025.02.031 Authors: Xie Z, Rose L, Feng J, Zhao Y, Lu Y, Kane H, Hibberd TJ, Hu X, Wang Z, Zang K, Yang X, Richardson Q, Othman R, Venezia O, Zhakyp A, Gao F, Abe N, Vigeland K, Wang…
Nociceptor neurons promote PDAC progression and cancer pain by interaction with cancer-associated fibroblasts and suppression of natural killer cells.
Source: Cell Res 2025 Mar 24;. doi: 10.1038/s41422-025-01098-4 Authors: Wang K, Ni B, Xie Y, Li Z, Yuan L, Meng C, Zhao T, Gao S, Huang C, Wang H, Ma Y, Zhou T, Feng Y, Chang A, Yang C, Yu J, Yu W, Zang F,…
Changes in Cytokines and Fibrotic Growth Factors after Low-Carbohydrate or Low-Fat Low-Energy Diets in Females with Lipedema.
Source: Curr Dev Nutr 2025 Mar; 9(3). doi: 10.1016/j.cdnut.2025.104571Authors: Lundanes J, Nes VF, Aakervik O, Ryan L, Hansson P, Rokstad AM, Martins C, Nymo S Lipedema is considered an inflammation-related disease, and low-carbohydrate ketogenic diets may help reduce inflammation. However, no randomized controlled trials have…
Statistical analysis plan for the Petal trial: the effects of parental touch on relieving acute procedural pain in neonates.
Source: Wellcome Open Res 2023; 8. doi: 10.12688/wellcomeopenres.19819.3Authors: Baxter L, Hauck AGV, Bhatt A, Cobo MM, Hartley C, Marchant S, Poorun R, van der Vaart M, Slater R Infants undergo multiple clinically-required painful procedures during their time in hospital, and there is an increasing desire…
A home-based EEG neurofeedback treatment for chronic neuropathic pain-a pilot study.
Source: Front Pain Res (Lausanne) 2025; 6. doi: 10.3389/fpain.2025.1479914Authors: Sakel M, Ozolins CA, Saunders K, Biswas R This study assessed the effect of an 8-week home-based neurofeedback intervention in chronic neuropathic pain patients. Pubmed ID: https://pubmed.ncbi.nlm.nih.gov/40134759/
Virtual reality improves pain threshold and recall in healthy adults: A randomized, crossover study.
Source: J Clin Anesth 2025 Mar 20; 103. doi: 10.1016/j.jclinane.2025.111816Authors: Rodriguez ST, Jimenez RT, Wang EY, Zuniga-Hernandez M, Titzler J, Jackson C, Suen MY, Yamaguchi C, Ko B, Kong JT, Caruso TJ Virtual reality (VR) is an emerging technology increasingly used to ameliorate acute and…
VR-guided exercise and mindfulness program for people with chronic pain: a randomised controlled cross-over pilot trial.
Source: BMC Sports Sci Med Rehabil 2025 Mar 21; 17(1). doi: 10.1186/s13102-025-01102-9Authors: Provan SA, Calogiuri G, Røset L, Mariussen M, Rosøy I, Johnsen TJ, Johansen T, Flaten OE, Litleskare S Physical exercises and mindfulness are important components in the management of chronic pain, but pain…
Integrating Data Mining with Transcranial Focused Ultrasound to Refine Neuralgia Treatment Strategies.
Source: J Neurosci Methods 2025 Mar 23; . doi: 10.1016/j.jneumeth.2025.110433Authors: Khan MA, Alsenan S, Algamdi SA, Aldossary H, Raju KN, Baili J, Saleem MA Neuralgia and other neuropathic pain are difficult to treat owing to their complicated etiology and a wide variety of responses to…
A comprehensive protocol for simplified mouse DRG fixation, processing and F4/80 immunohistochemistry: Overcoming common challenges.
Source: J Neurosci Methods 2025 Mar 23; . doi: 10.1016/j.jneumeth.2025.110434Authors: Tay N, Alshammari A, Kaur S, Pettit A, Mu E, Reid A, Winkler I, Vetter I, Starobova H Dorsal root ganglia (DRGs) contain the cell bodies of sensory neurons and non-neuronal cells that play a…
Research waste in randomised trials of exercise treatments for chronic low back pain: trial sequential and cumulative meta-analyses by publication date and size.
Source: BMJ Open 2025 Mar 25; 15(3). doi: 10.1136/bmjopen-2024-087787Authors: Chamberlain F, Elliott L, Yarahmadi A, Underwood M To determine if there is research waste in controlled trials of exercise therapies compared with usual care/no treatment for adults with chronic non-specific lower back pain. Pubmed ID: https://pubmed.ncbi.nlm.nih.gov/40132821/
SIRT1 Attenuates Neuropathic Pain via CDK5-Kalirin-7 Signaling Pathway in Type 2 Diabetic Rats.
Source: Mol Neurobiol 2025 Mar 25; . doi: 10.1007/s12035-025-04843-3Authors: Xie C, Cao Y, Shen Y, Wu S, Wang J, Ye X, Wei N, Cao H, Li J Evidence has continually accumulated to illustrate that sirtuin 1 (SIRT1) is a major factor in multiple animal models…
Mitochondria-targeting Bimetallic Cluster Nanozymes Alleviate Neuropathic Pain Through Scavenging ROS and Reducing Inflammation.
Source: Adv Healthc Mater 2025 Mar; 14(8). doi: 10.1002/adhm.202401607Authors: Cheng X, Xia T, Han M, Xu M, Yuan W, Wei Z, Jiang W, Tang H, Bai Q, Gu X Neuropathic pain is a significant public health concern. Inflammatory mediators and reactive oxygen species (ROS) are…
Improvement of irritable bowel syndrome with glucagon like peptide-1 receptor agonists: a systematic review and meta-analysis.
Source: Front Endocrinol (Lausanne) 2025; 16. doi: 10.3389/fendo.2025.1548346Authors: Mostafa MEA, Alrasheed T Irritable bowel syndrome (IBS) is a severe gastrointestinal condition with symptoms like pain, bloating, diarrhea, and constipation. Glucagon-like peptide-1 (GLP-1) receptors, expressed in the central nervous system and peripheral tissues, have been found…
A scoping review of spinal cord stimulation for phantom limb pain.
Source: Interv Pain Med 2025 Mar; 4(1). doi: 10.1016/j.inpm.2025.100571Authors: Jaffee S, Verma R, Vaezi M, Kite T, Tomycz N Phantom limb pain (PLP) is a debilitating condition that affects individuals following limb amputation. While medical management with anticonvulsants and physical therapy is the first-line treatment,…
Non-Cognitive Behavioral Therapy Psychological Interventions May Not Make the Difference in Children and Adolescents With Chronic Pain.
Source: J Pain Res 2025; 18. doi: 10.2147/JPR.S503542Authors: Perlman L, Malka N, Terry O, Nguyen A, Guimarães Ferreira Fonseca L, Ingelmo JI, Ingelmo P Chronic pain in pediatric populations presents a multifaceted challenge with biopsychosocial impact, requiring a multidisciplinary approach including psychological treatment. At our…
Hyperalgesic Priming in the Transition From Acute to Chronic Pain: Focus on Different Models and the Molecular Mechanisms Involved.
Source: J Pain Res 2025; 18. doi: 10.2147/JPR.S514851Authors: Zhang M, Li N, Zhao S, Feng X Poorly treated acute pain can develop into chronic pain, resulting in significant impairment of patients’ quality of life. The hyperalgesic priming model is commonly used to study how acute…
The Impact of Biseasonal Time Changes on Migraine.
Source: Neurol Int 2025 Mar 05; 17(3). doi: 10.3390/neurolint17030040Authors: Göbel CH, Heinze-Kuhn K, Heinze A, Cirkel A, Göbel H : Changes in the daily rhythm can trigger migraine attacks. The sensitivity for triggering attacks is closely linked to the regulation of biological rhythms controlled by…
Bioinformatic strategies in metagenomics of chronic prostatitis.
Source: World J Urol 2025 Mar 26; 43(1). doi: 10.1007/s00345-025-05514-7Authors: Davasaz Tabrizi E, Sevil M, Arican E Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a prevalent urological condition in young men, significantly affecting quality of life due to persistent discomfort and neuropsychological symptoms. Despite its…
Blockade of IgG Fc receptors reduces pain after intervertebral disc injury.
Source: Pharmacol Rep 2025 Mar 26; . doi: 10.1007/s43440-025-00720-xAuthors: Shi X, Sahbaie P, Guo TZ, Hsu YM, Kingery WS, Clark JD Intervertebral disc (IVD) injury is a common cause of low back pain and disability. Recent evidence suggests that autoantibodies contribute to such pain. We,…
Electroacupuncture Improves the Motor Function in Rats with Spinal Cord Injury by Regulating UCN2-Mediated cAMP-PKA Signaling in the Spinal Cord Microenvironment.
Source: Cell Mol Neurobiol 2025 Mar 26; 45(1). doi: 10.1007/s10571-025-01537-1Authors: Hu Y, Tang X, Li S, Liu P, Zhang K, Zhao L, Dou F, Zhang B Spinal cord injury (SCI) has a high mortality and disability rate and can result in severe neurological deficits and…
The Relationship Between Metabolic Syndrome and Pain Catastrophizing in Psoriatic Arthritis.
Source: Rheumatol Ther 2025 Mar 26; . doi: 10.1007/s40744-025-00758-6Authors: Currado D, Berardicurti O, Saracino F, Trunfio F, Kun L, Marino A, Corberi E, Lamberti L, Ruscitti P, Liakouli V, Vadacca M, Rigon A, Arcarese L, Pietramale M, De Vincenzo F, Vomero M, Ciccia F, Giacomelli…
Pain-on-a-Chip: A microfluidic device for neuron differentiation and functional discrimination in animal models of chronic pain.
Source: Biosens Bioelectron 2025 Mar 19; 279. doi: 10.1016/j.bios.2025.117401Authors: Zhu D, Nilghaz A, Tong Z, Poole DP, O’Sullivan K, Imlach WL, Haberberger RV, Veldhuis NA, Matusica D, Voelcker NH Chronic pain is a global health issue that is poorly understood and challenging to treat. Improving…
Global, regional and national temporal trends in prevalence for migraine in women of childbearing age: an updated age-period-cohort analysis based on Global Burden of Disease Study 2021.
Source: Neuroepidemiology 2025 Mar 26; . doi: 10.1159/000545221Authors: Hu B, Qiu X, Wang Y, Wei X, Feng J, Hou L To provide a comprehensive assessment of temporal trends in migraine prevalence among women of childbearing age (WCBA) at global, regional and national levels from 1992…
Non-pharmacological and non-surgical treatments for low back pain in adults: an overview of Cochrane reviews.
Source: Cochrane Database Syst Rev 2025 Mar 27; 3. doi: 10.1002/14651858.CD014691.pub2Authors: Rizzo RR, Cashin AG, Wand BM, Ferraro MC, Sharma S, Lee H, O’Hagan E, Maher CG, Furlan AD, van Tulder MW, McAuley JH Low back pain (LBP) is a significant public health issue due…