March 18-24, 2023
Showing 1-25 of 124.
Gut enterochromaffin cells drive visceral pain and anxiety.
Source: Nature 2023 Mar 22;. doi: 10.1038/s41586-023-05829-8 Authors: Bayrer JR, Castro J, Venkataraman A, Touhara KK, Rossen ND, Morrie RD, Maddern J, Hendry A, Braverman KN, Garcia-Caraballo S, Schober G, Brizuela M, Castro Navarro FM, Bueno-Silva C, Ingraham HA, Brierley SM, Julius D Gastrointestinal (GI)…
Identification of brain-to-spinal circuits controlling the laterality and duration of mechanical allodynia in mice.
Source: Cell Rep 2023 Mar 22; 42(4). doi: 10.1016/j.celrep.2023.112300 Authors: Huo J, Du F, Duan K, Yin G, Liu X, Ma Q, Dong D, Sun M, Hao M, Su D, Huang T, Ke J, Lai S, Zhang Z, Guo C, Sun Y, Cheng L Mechanical…
Comparative effectiveness and safety of analgesic medicines for adults with acute non-specific low back pain: systematic review and network meta-analysis.
Source: BMJ 2023 Mar 22; 380. doi: 10.1136/bmj-2022-072962 Authors: Wewege MA, Bagg MK, Jones MD, Ferraro MC, Cashin AG, Rizzo RR, Leake HB, Hagstrom AD, Sharma S, McLachlan AJ, Maher CG, Day R, Wand BM, O’Connell NE, Nikolakopolou A, Schabrun S, Gustin SM, McAuley JH…
Research objectives and general considerations for pragmatic clinical trials of pain treatments: IMMPACT statement.
Source: Pain 2023 Mar 22;. doi: 10.1097/j.pain.0000000000002888 Authors: Hohenschurz-Schmidt DJ, Cherkin D, Rice ASC, Dworkin RH, Turk DC, McDermott MP, Bair MJ, DeBar LL, Edwards RR, Farrar JT, Kerns RD, Markman JD, Rowbotham MC, Sherman KJ, Wasan AD, Cowan P, Desjardins P, Ferguson M, Freeman…
Establishment of a core outcome set for burn care research: development and international consensus.
Source: BMJ Med 2022; 1(1). doi: 10.1136/bmjmed-2022-000183Authors: Young A, Davies A, Tsang C, Kirkham J, Potokar T, Gibran N, Tyack Z, Meirte J, Harada T, Dheansa B, Dumville J, Metcalfe C, Ahuja R, Wood F, Gaskell S, Brookes S, Smailes S, Jeschke M, Cinar MA,…
Conflicts hurt: social stress predicts elevated pain and sadness after mild inflammatory increases.
Source: Pain 2023 Mar 22; . doi: 10.1097/j.pain.0000000000002894Authors: Madison AA, Renna M, Andridge R, Peng J, Shrout MR, Sheridan J, Lustberg M, Ramaswamy B, Wesolowski R, Williams NO, Noonan AM, Reinbolt RE, Stover DG, Cherian MA, Malarkey WB, Kiecolt-Glaser JK Individuals respond differently to inflammation….
Self-administered stretching exercises are as effective as motor control exercises for people with chronic non-specific low back pain: a randomised trial.
Source: J Physiother 2023 Mar 21; . doi: 10.1016/j.jphys.2023.02.016Authors: Turci AM, Nogueira CG, Nogueira Carrer HC, Chaves TC In people with chronic non-specific low back pain, what is the effect of self-administered stretching exercises relative to motor control exercises on pain intensity, disability, fear avoidance,…
Clinical Efficacy and Immune Effects of Acupuncture in Patients with Comorbid Chronic Pain and Major Depression Disorder: A Double-Blinded, Randomized Controlled Crossover Study.
Source: Brain Behav Immun 2023 Mar 20; . doi: 10.1016/j.bbi.2023.03.016Authors: Liao HY, Kumaran Satyanarayanan S, Lin YW, Su KP Depression and pain are highly comorbid and share biological mechanisms. Acupuncture is commonly used to manage both pain and depression, but the choice of acupoints for…
Effects of oxycodone pharmacogenetics on postoperative analgesia and related clinical outcomes in children: a pilot prospective study.
Source: Pharmacogenomics 2023 Mar 22; . doi: 10.2217/pgs-2022-0149Authors: Aruldhas BW, Quinney SK, Packiasabapathy S, Overholser BR, Raymond O, Sivam S, Sivam I, Velu S, Montelibano A, Sadhasivam S Variability in the pharmacokinetics and pharmacodynamics of oxycodone in children undergoing surgery could be due to genetic…
Long-term treatment with lasmiditan in patients with migraine: Results from the open-label extension of the CENTURION randomized trial.
Source: Cephalalgia 2023 Apr; 43(4). doi: 10.1177/03331024231161745Authors: Ashina M, Roos C, Li LQ, Komori M, Ayer D, Ruff D, Krege JH Following the CENTURION phase 3 randomized controlled trial’s four-month double-blind phase, this 12-month open-label extension collected data for up to one year about dose…
Galcanezumab effects on incidence of headache after occurrence of triggers, premonitory symptoms, and aura in responders, non-responders, super-responders, and super non-responders.
Source: J Headache Pain 2023 Mar 16; 24(1). doi: 10.1186/s10194-023-01560-xAuthors: Ashina S, Melo-Carrillo A, Toluwanimi A, Bolo N, Szabo E, Borsook D, Burstein R The goal of this observational, open-label, cohort study was to determine whether prophylactic migraine treatment with galcanezumab, a peripherally acting drug,…
A Link Between Inflammatory Mechanisms and Fibromyalgia.
Source: Adv Exp Med Biol 2023; 1411. doi: 10.1007/978-981-19-7376-5_16Authors: Bains A, Kohrman S, Punko D, Fricchione G Fibromyalgia (FM) is a condition characterized by chronic widespread pain, which has traditionally been considered psychogenic in nature due to lack of known underlying organic pathophysiology. In more…
Real-life effectiveness and safety of tofacitinib treatment in patients with ulcerative colitis: a KASID multicenter cohort study.
Source: Therap Adv Gastroenterol 2023; 16. doi: 10.1177/17562848231154103Authors: Shin SH, Oh K, Hong SN, Lee J, Oh SJ, Kim ES, Na SY, Kang SB, Koh SJ, Bang KB, Jung SA, Jung SH, Kim KO, Park SH, Yang SK, Choi CH, Ye BD Tofacitinib is a…
Characterization and role exploration of ferroptosis-related genes in osteoarthritis.
Source: Front Mol Biosci 2023; 10. doi: 10.3389/fmolb.2023.1066885Authors: Wang X, Liu T, Qiu C, Yu S, Zhang Y, Sheng Y, Wu C Osteoarthritis (OA), viewing as a degenerative aseptic inflammatory disease, is characterized by joint pain and inflammation that significantly affects the quality of patients’…
Machine learning algorithms distinguish discrete digital emotional fingerprints for web pages related to back pain.
Source: Sci Rep 2023 Mar 21; 13(1). doi: 10.1038/s41598-023-31741-2Authors: Caldo D, Bologna S, Conte L, Amin MS, Anselma L, Basile V, Hossain MM, Mazzei A, Heritier P, Ferracini R, Kon E, De Nunzio G Back pain is the leading cause of disability worldwide. Its emergence…
Initial treatment approaches and healthcare utilization among veterans with low back pain: a propensity score analysis.
Source: BMC Health Serv Res 2023 Mar 21; 23(1). doi: 10.1186/s12913-023-09207-yAuthors: Schmidt C, Borgia M, Zhang T, Gochyyev P, Shireman TI, Resnik L Opioid prescriptions for Veterans with low back pain (LBP) persist despite the availability of PT, a lower medical risk treatment option. Patterns…
Microglia sustain anterior cingulate cortex neuronal hyperactivity in nicotine-induced pain.
Source: J Neuroinflammation 2023 Mar 21; 20(1). doi: 10.1186/s12974-023-02767-0Authors: Long DD, Zhang YZ, Liu A, Shen L, Wei HR, Lou QQ, Hu SS, Chen DY, Chai XQ, Wang D Long-term smoking is a risk factor for chronic pain, and chronic nicotine exposure induces pain-like effects…
Genome-wide association study suggests a critical contribution of the adaptive immune system to chronic post-surgical pain.
Source: medRxiv 2023 Mar 10; . doi: 10.1101/2023.01.24.23284520Authors: Parisien M, van Reij RRI, Khoury S, Koseli E, Karaky M, van den Hoogen NJ, Peng G, Allegri M, de Gregori M, Chelly JE, Rakel BA, Aasvang EK, Kehlet H, Buhre WFFA, Bryant CD, Damaj MI, King…
Immunometabolic rewiring in long COVID patients with chronic headache.
Source: bioRxiv 2023 Mar 06; . doi: 10.1101/2023.03.06.531302Authors: Foo SS, Chen W, Jung KL, Azamor T, Choi UY, Zhang P, Comhair SA, Erzurum SC, Jehi L, Jung JU Almost 20% of patients with COVID-19 experience long-term effects, known as post-COVID condition or long COVID. Among…
The parabrachial to central amygdala circuit is a key mediator of injury-induced pain sensitization.
Source: bioRxiv 2023 Feb 09; . doi: 10.1101/2023.02.08.527340Authors: Torres-Rodriguez JM, Wilson TD, Singh S, Chaudhry S, Adke AP, Becker JJ, Lin JL, Gonzalez SM, Soler-Cedeño O, Carrasquillo Y The spino-ponto-amygdaloid pathway is a major ascending circuit relaying nociceptive information from the spinal cord to the…
Current and emerging pharmacotherapy for menstrual migraine: a narrative review.
Source: Expert Opin Pharmacother 2023 Mar 23; . doi: 10.1080/14656566.2023.2194487Authors: Ceriani CEJ, Silberstein SD In this article, we discuss menstrual migraine (MM), which can be categorized as menstrually related migraine (MRM) or pure menstrual migraine (PMM). MM attacks are often longer, more severe, and harder…
Prevalence, natural history and dynamic nature of chronic headache and medication overuse headache in Italy: The SPARTACUS study.
Source: Cephalalgia 2023 Apr; 43(4). doi: 10.1177/03331024231157677Authors: Favoni V, Mascarella D, Giannini G, Bauleo S, Torelli P, Pierangeli G, Cortelli P, Cevoli S Chronic headaches and medication overuse headache are common and burdening conditions. No studies have evaluated the prevalence of chronic headache and medication…
Managing Older Adults’ Chronic Pain: Higher-Risk Interventions.
Source: Am J Nurs 2023 Apr 01; 123(4). doi: 10.1097/01.NAJ.0000925528.83750.03Authors: Arnstein P, Shade M, Herr KA, Young HM, Fishman SM This article is part of a series, Supporting Family Caregivers: No Longer Home Alone, published in collaboration with the AARP Public Policy Institute. Results of…
Sumatriptan as a First-Line Treatment for Headache in the Pediatric Emergency Department.
Source: Pediatr Neurol 2023 Feb 04; 142. doi: 10.1016/j.pediatrneurol.2023.01.016Authors: Hauser Chatterjee J, Hartford EA, Law E, Barry D, Blume H Headache is a common presenting condition for patients seen in the pediatric emergency department (ED). Intranasal (IN) sumatriptan is a well-tolerated and safe abortive treatment…
Hydrogen peroxide production by epidermal dual oxidase 1 regulates nociceptive sensory signals.
Source: Redox Biol 2023 Mar 15; 62. doi: 10.1016/j.redox.2023.102670Authors: Pató A, Bölcskei K, Donkó Á, Kaszás D, Boros M, Bodrogi L, Várady G, Pape VFS, Roux BT, Enyedi B, Helyes Z, Watt FM, Sirokmány G, Geiszt M Keratinocytes of the mammalian skin provide not only…