March 16-22, 2024
Showing 1-25 of 81.
TRPV1 analgesics disturb core body temperature via a biased allosteric mechanism involving conformations distinct from that for nociception.
Source: Neuron 2024 Mar 11;. doi: 10.1016/j.neuron.2024.02.016 Authors: Huang YZ, Ma JX, Bian YJ, Bai QR, Gao YH, Di SK, Lei YT, Yang H, Yang XN, Shao CY, Wang WH, Cao P, Li CZ, Zhu MX, Sun MY, Yu Y Efforts on developing transient receptor…
Infraorbital nerve injury triggers sex-specific neuroimmune responses in the peripheral trigeminal pathway and common pain behaviours.
Source: Brain Behav Immun 2024 Mar 16;. doi: 10.1016/j.bbi.2024.03.022 Authors: Kang JWM, Davanzo OI, Emvalomenos GM, Mychasiuk R, Henderson LA, Keay KA Trigeminal neuropathic pain is emotionally distressing and disabling. It presents with allodynia, hyperalgesia and dysaesthesia. In preclinical models it has been assumed that…
Disassembly of the TRIM56-ATR complex promotes cytoDNA/cGAS/STING axis-dependent intervertebral disc inflammatory degeneration.
Source: J Clin Invest 2024 Jan 23; 134(6). doi: 10.1172/JCI165140 Authors: Zhang W, Li G, Zhou X, Liang H, Tong B, Wu D, Yang K, Song Y, Wang B, Liao Z, Ma L, Ke W, Zhang X, Lei J, Lei C, Feng X, Wang K,…
Design, Synthesis, and In Vivo Evaluation of a New Series of Indole-Chalcone Hybrids as Analgesic and Anti-Inflammatory Agents.
Source: ACS Omega 2024 Mar 12; 9(10). doi: 10.1021/acsomega.4c00026Authors: Baramaki I, Altıntop MD, Arslan R, Alyu Altınok F, Özdemir A, Dallali I, Hasan A, Bektaş Türkmen N Indole-chalcone hybrids have burst into prominence as potent weapons in the battle against pain and inflammation due to…
In silico exploration of CB2 receptor agonist in the management of neuroinflammatory conditions by pharmacophore modeling.
Source: Comput Biol Chem 2024 Mar 10; 110. doi: 10.1016/j.compbiolchem.2024.108049Authors: Bodke S, Joshi N, Alavala RR, Suares D Endocannabinoid system plays a pivotal role in controlling neuroinflammation, and modulating this system may not only aid in managing symptoms of neurodegenerative diseases such as Alzheimer’s disease,…
Protease-induced excitation of dorsal root ganglion neurons in response to acute perturbation of the gut microbiota is associated with visceral and somatic hypersensitivity.
Source: Cell Mol Gastroenterol Hepatol 2024 Mar 15; . doi: 10.1016/j.jcmgh.2024.03.006Authors: Baker CC, Sessenwein JL, Wood HM, Yu Y, Tsang Q, Alward TA, Jimenez Vargas NN, Omar AA, McDonnel A, Segal J, Sjaarda CP, Bunnett NW, Schmidt BL, Caminero A, Boev N, Bannerman C, Ghasemlou…
Global, regional, and national burden of disorders affecting the nervous system, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021.
Source: Lancet Neurol 2024 Mar 05; . doi: 10.1016/S1474-4422(24)00038-3Authors: Disorders affecting the nervous system are diverse and include neurodevelopmental disorders, late-life neurodegeneration, and newly emergent conditions, such as cognitive impairment following COVID-19. Previous publications from the Global Burden of Disease, Injuries, and Risk Factor Study…
Low-intensity pulsed ultrasound delays the progression of osteoarthritis by regulating the YAP-RIPK1-NF-κB axis and influencing autophagy.
Source: J Transl Med 2024 Mar 16; 22(1). doi: 10.1186/s12967-024-05086-xAuthors: Pan C, Lu F, Hao X, Deng X, Liu J, Sun K, Hou W, Shang X, Chi R, Guo F, Xu T Osteoarthritis (OA) is a degenerative disease characterized by chronic inflammation of the joint….
Olfactory ensheathing cells as candidate cells for chronic pain treatment.
Source: J Chem Neuroanat 2024 Mar 14; . doi: 10.1016/j.jchemneu.2024.102413Authors: Liu MC, Guo QF, Zhang WW, Luo HL, Zhang WJ, Hu HJ Chronic pain is often accompanied by tissue damage and pain hypersensitivity. It easily relapses and is challenging to cure, which seriously affects the…
Age, Race, Ethnicity, and Sex of Participants in Clinical Trials Focused on Chronic Pain.
Source: J Pain 2024 Mar 14; . doi: 10.1016/j.jpain.2024.03.007Authors: Boyd T, Chibueze J, Pester BD, Saini R, Bar N, Edwards RR, Adams MCB, Silver JK, Meints SM, Burton-Murray H There are limited data on equitable inclusion in chronic pain trials. We aimed to (1) identify…
Parent Anxiety, Depression, Protective Responses, and Parenting Stress in the Context of Parent and Child Chronic Pain: A Daily Diary Study of Parent Variability.
Source: J Pain 2024 Mar 14; . doi: 10.1016/j.jpain.2024.03.008Authors: Beveridge JK, Walker A, Orr SL, Wilson AC, Birnie KA, Noel M Parents with (versus without) chronic pain report poorer psychosocial functioning (e.g., worse mental health, parenting difficulties), which has been linked to poorer child outcomes…
Interactions between skin-resident dendritic and Langerhans cells and pain-sensing neurons.
Source: J Allergy Clin Immunol 2024 Mar 14; . doi: 10.1016/j.jaci.2024.03.006Authors: Wilcox NC, Taheri G, Halievski K, Talbot S, Silva JR, Ghasemlou N Various immune cells in the skin contribute to its function as a first line of defence against infection/disease, while its dense innervation…
Role of gut-derived bacterial lipopolysaccharide and peripheral TLR4 in immobilization stress-induced itch aggravation in a mouse model of atopic dermatitis.
Source: Sci Rep 2024 Mar 15; 14(1). doi: 10.1038/s41598-024-56936-zAuthors: Cho DE, Hong JP, Kim Y, Sim JY, Kim HS, Kim SR, Lee B, Cho HS, Cho IH, Shin S, Yeom M, Kwon SK, Lee IS, Park H, Kim K, Hahm DH Psychological stress and intestinal…
Curcumin analogue NL04 inhibits spinal cord central sensitization in rats with bone cancer pain by inhibiting NLRP3 inflammasome activation and reducing IL-1β production.
Source: Eur J Pharmacol 2024 Mar 13; . doi: 10.1016/j.ejphar.2024.176480Authors: Chen L, Hua B, He Q, Han Z, Wang Y, Chen Y, Ni H, Zhu Z, Xu L, Yao M, Ni C The management and therapy of bone cancer pain (BCP) remain formidable clinical challenges….
Painful diabetic neuropathy: The role of ion channels.
Source: Biomed Pharmacother 2024 Mar 14; 173. doi: 10.1016/j.biopha.2024.116417Authors: Wang Q, Ye Y, Yang L, Xiao L, Liu J, Zhang W, Du G Painful diabetic neuropathy (PDN) is a common chronic complication of diabetes that causes neuropathic pain and negatively affects the quality of life….
Neuroinflammation in the paraventricular nucleus of the hypothalamus precipitates visceral pain induced by pancreatic cancer in mice.
Source: J Gastrointest Oncol 2024 Feb 29; 15(1). doi: 10.21037/jgo-24-42Authors: Ji NN, Li ZY, Cao S, Pei B, Jin CY, Li YF, Mao P, Jiang H, Fan BF, Xia M Given the pivotal role of neuroinflammation in chronic pain and that the paraventricular nucleus of…
Advances in understanding migraine pathophysiology: a bench to bedside review of research insights and therapeutics.
Source: Front Mol Neurosci 2024; 17. doi: 10.3389/fnmol.2024.1355281Authors: Frimpong-Manson K, Ortiz YT, McMahon LR, Wilkerson JL The individual and global burden of migraine is of such significance that there are accelerated efforts to develop new therapies. New migraine therapeutics are needed to address the current…
Cognitive Functional Therapy compared with usual physiotherapy care in people with persistent low back pain: a mixed methods feasibility randomised controlled trial in the United Kingdom National Health Service.
Source: Physiotherapy 2024 Feb 12; 123. doi: 10.1016/j.physio.2024.02.003Authors: Newton C, Singh G, Nolan D, Booth V, Diver C, O’Neill S, Purtill H, Logan P, O’Sullivan K, O’Sullivan P To determine the feasibility of completing a definitive randomised controlled trial (RCT), evaluating the clinical and cost-effectiveness…
Genetics of migraine: complexity, implications, and potential clinical applications.
Source: Lancet Neurol 2024 Apr; 23(4). doi: 10.1016/S1474-4422(24)00026-7Authors: Sutherland HG, Jenkins B, Griffiths LR Migraine is a common neurological disorder with large burden in terms of disability for individuals and costs for society. Accurate diagnosis and effective treatments remain priorities. Understanding the genetic factors that…
Cristina Tassorelli: making a difference in headache research.
Source: Lancet Neurol 2024 Apr; 23(4). doi: 10.1016/S1474-4422(24)00090-5Authors: Samarasekera U Pubmed ID: https://pubmed.ncbi.nlm.nih.gov/38508831/
Pyroptotic T cell-derived active IL-16 has a driving function in ovarian endometriosis development.
Source: Cell Rep Med 2024 Mar 19; 5(3). doi: 10.1016/j.xcrm.2024.101476Authors: Zhang J, Zhao W, Zhou Y, Xi S, Xu X, Du X, Zheng X, Hu W, Sun R, Tian Z, Fu B, Wei H Endometriosis, affecting 6%-10% of women, often leads to pain and infertility…
Unlocking hypnotizability: Transcranial brain stimulation for enhanced impact in chronic pain.
Source: Cell Rep Med 2024 Mar 19; 5(3). doi: 10.1016/j.xcrm.2024.101475Authors: Marchand S Hypnosis provides a therapeutic option for health issues like chronic pain, but individual responsiveness, termed hypnotizability, varies. Faerman et al.’s study showed that transcranial magnetic stimulation (TMS) can significantly improve hypnotizability, offering potential for…
Ferroptosis and oxidative stress in endometriosis: A systematic review of the literature.
Source: Medicine (Baltimore) 2024 Mar 15; 103(11). doi: 10.1097/MD.0000000000037421Authors: Ni C, Li D Endometriosis (EMT) a common gynecological condition in women, an inflammatory disease characterized by the presence of endometrial tissue on organs and tissues in the pelvis, and is mainly associated with chronic pelvic…
Specific cognitive and psychological alterations are more strongly linked to increased migraine disability than chronic migraine diagnosis.
Source: J Headache Pain 2024 Mar 15; 25(1). doi: 10.1186/s10194-024-01734-1Authors: Castro Zamparella T, Carpinella M, Peres M, Cuello FP, Maza P, Van Gansen M, Filipchuk M, Balaszczuk V, Maldonado C, Scarnato P, Conci Magris D, Lisicki M The efficiency of The International Classification of Headache…
Dominant CST3 variants cause adult onset leukodystrophy without amyloid angiopathy.
Source: Brain 2024 Mar 15; . doi: 10.1093/brain/awae085Authors: Bergner CG, Breur M, Soto-Bernardini MC, Schäfer L, Lier J, Le Duc D, Bundalian L, Schubert S, Brenner D, Kreuz FR, Schulte B, Waisfisz Q, Bugiani M, Köhler W, Sticht H, Abou Jamra R, van der Knaap…