July 27 - August 2, 2024
Showing 1-25 of 133.
A chemogenetic screen reveals that Trpv1-expressing neurons control regulatory T cells in the gut.
Source: Science 2024 Aug 02; 385(6708). doi: 10.1126/science.adk1679 Authors: Zhu Y, Meerschaert KA, Galvan-Pena S, Bin NR, Yang D, Basu H, Kawamoto R, Shalaby A, Liberles SD, Mathis D, Benoist C, Chiu IM Neuroimmune cross-talk participates in intestinal tissue homeostasis and host defense. However, the…
Pannexin-1 channel inhibition alleviates opioid withdrawal in rodents by modulating locus coeruleus to spinal cord circuitry.
Source: Nat Commun 2024 Jul 24; 15(1). doi: 10.1038/s41467-024-50657-7 Authors: Kwok CHT, Harding EK, Burma NE, Markovic T, Massaly N, van den Hoogen NJ, Stokes-Heck S, Gambeta E, Komarek K, Yoon HJ, Navis KE, McAllister BB, Canet-Pons J, Fan C, Dalgarno R, Gorobets E, Papatzimas…
Neural circuit basis of placebo pain relief.
Source: Nature 2024 Jul 24;. doi: 10.1038/s41586-024-07816-z Authors: Chen C, Niehaus JK, Dinc F, Huang KL, Barnette AL, Tassou A, Shuster SA, Wang L, Lemire A, Menon V, Ritola K, Hantman A, Zeng H, Schnitzer MJ, Scherrer G Placebo effects are striking demonstrations of mind-body…
Descending facilitation from rostral ventromedial medulla mu opioid receptor-expressing neurons is necessary for maintenance of sensory and affective dimensions of chronic neuropathic pain.
Source: Pain 2024 Jul 26;. doi: 10.1097/j.pain.0000000000003360 Authors: Dogrul BN, Machado Kopruszinski C, Dolatyari Eslami M, Watanabe M, Luo S, Moreira de Souza LH, Vizin RL, Yue X, Palmiter RD, Navratilova E, Porreca F Pharmacological ablation of rostral ventromedial medulla (RVM) mu opioid receptor-expressing cells…
Nemolizumab with concomitant topical therapy in adolescents and adults with moderate-to-severe atopic dermatitis (ARCADIA 1 and ARCADIA 2): results from two replicate, double-blind, randomised controlled phase 3 trials.
Source: Lancet 2024 Jul 24; . doi: 10.1016/S0140-6736(24)01203-0Authors: Silverberg JI, Wollenberg A, Reich A, Thaçi D, Legat FJ, Papp KA, Stein Gold L, Bouaziz JD, Pink AE, Carrascosa JM, Rewerska B, Szepietowski JC, Krasowska D, Havlíčková B, Kalowska M, Magnolo N, Pauser S, Nami N,…
Prevalence, pain trajectories, and presurgical predictors for chronic postsurgical pain in a pediatric sample in Spain with a 24-month follow-up.
Source: Pain 2024 Jul 10; . doi: 10.1097/j.pain.0000000000003330Authors: Ceniza-Bordallo G, Gómez Fraile A, Martín-Casas P, Rabbitts JA, Li R, Palermo TM, López-de-Uralde-Villanueva I Pediatric chronic pain, particularly chronic postsurgical pain (CPSP), poses a significant public health challenge, impacting 20% of pediatric populations. While several presurgical…
Randomized placebo controlled trial of phytoterpenes in DMSO for the treatment of plantar fasciitis.
Source: Sci Rep 2024 Jul 31; 14(1). doi: 10.1038/s41598-024-65979-1Authors: Burke BE, Baillie JE Plantar fasciitis is the most common cause of heel pain in adults with an overall prevalence of 0.85% in the adult population of the US, affecting over 2 million adults annually. Most…
Clinical relevance of combined treatment with exercise in patients with chronic low back pain: a randomized controlled trial.
Source: Sci Rep 2024 Jul 24; 14(1). doi: 10.1038/s41598-024-68192-2Authors: Blanco-Giménez P, Vicente-Mampel J, Gargallo P, Baraja-Vegas L, Bautista IJ, Ros-Bernal F, Barrios C Low back pain is a widespread public health concern owing to its high prevalence rates according to the Global Burden of Diseases….
Noninvasive targeted modulation of pain circuits with focused ultrasonic waves.
Source: Pain 2024 Jul 30; . doi: 10.1097/j.pain.0000000000003322Authors: Riis TS, Feldman DA, Losser AJ, Okifuji A, Kubanek J Direct interventions into deep brain circuits constitute promising treatment modalities for chronic pain. Cingulotomy and deep brain stimulation targeting the anterior cingulate cortex have shown notable improvements…
(+)-Catechin attenuates CCI-induced neuropathic pain in male rats by promoting the Nrf2 antioxidant pathway to inhibit ROS/TLR4/NF-κB-mediated activation of the NLRP3 inflammasome.
Source: J Neurosci Res 2024 Aug; 102(8). doi: 10.1002/jnr.25372Authors: Jing B, Chen ZN, Si WM, Zhao JJ, Zhao GP, Zhang D The objective of this study was to investigate the potential mechanisms by which (+)-catechin alleviates neuropathic pain. Thirty-two male Sprague-Dawley rats were divided into…
Wireless Optogenetic Targeting Nociceptors Helps Host Cells Win the Competitive Colonization in Implant-Associated Infections.
Source: Small Methods 2024 Aug 01; . doi: 10.1002/smtd.202400216Authors: Fang X, Ding H, Chen Y, Wang Q, Yuan X, Zhang C, Huang J, Huang J, Lv J, Hu H, Huang C, Hu X, Lin Y, Zhang N, Zhou W, Huang Y, Li W, Niu S,…
A comprehensive review of phase 2/3 trials in osteoarthritis: an expert opinion.
Source: Expert Opin Emerg Drugs 2024 Aug 01; . doi: 10.1080/14728214.2024.2386174Authors: Pan L, Nagib L, Ganguly S, Moorthy A, Tahir H Osteoarthritis is a chronic, degenerative, and debilitating disease associated with significant long-term morbidity and disability. The pathogenesis of osteoarthritis is not completely understood but…
Current concepts and targets for preventing the transition of acute to chronic postsurgical pain.
Source: Curr Opin Anaesthesiol 2024 Aug 01; . doi: 10.1097/ACO.0000000000001424Authors: Oweidat A, Kalagara H, Sondekoppam RV It is estimated that approximately a third of patients undergoing certain surgeries may report some degree of persistent pain postoperatively. Chronic postsurgical pain (CPSP) reduces quality of life, is…
Meningeal lymphatic vessel dysfunction driven by CGRP signaling causes migraine-like pain in mice.
Source: J Clin Invest 2024 Aug 01; 134(15). doi: 10.1172/JCI182556Authors: Thomas JL, Schindler EA, Gottschalk C Migraines are a type of headache that occur with other neurological symptoms, but the pathophysiology remains unclear. In this issue of the JCI, Nelson-Maney and authors used constitutive and…
On-receptor computing with classical associative learning in semiconductor oxide memristors.
Source: Nanoscale 2024 Aug 01; . doi: 10.1039/d4nr02132kAuthors: Ju D, Lee J, Kim S The increasing demand for energy-efficient data processing leads to a growing interest in neuromorphic computing that aims to emulate cerebral functions. This approach offers cost-effective and rapid parallel data processing, surpassing…
Beyond movement: Headache in patients with functional movement disorders.
Source: Headache 2024 Aug 01; . doi: 10.1111/head.14804Authors: Riva E, Kurtis MM, Valls A, Franch O, Pareés I To evaluate headache comorbidity in a cohort of patients with functional movement disorders by assessing the prevalence, clinical characteristics, and temporal relationship of headache with the onset…
Plain Language Summary Publication: Hyperactivity of the medial thalamus in patients with photophobia-associated migraine.
Source: Headache 2024 Aug 01; . doi: 10.1111/head.14792Authors: Suzuki Y, Kiyosawa M, Wakakura M, Ishii K Pubmed ID: https://pubmed.ncbi.nlm.nih.gov/39087901/
A Multimodal Meta-Analysis of Structural and Functional Alterations in the Brain of Knee Osteoarthritis Systematic Review.
Source: Pain Physician 2024 Jul; 27(5). Authors: Cheng S, Dong X, Lai P, Chen X, Zhou J, Li Z, Wu X Abnormalities of structural and functional brain regions might influence the persistence of knee pain, the progression, and the response to treatments in knee osteoarthritis…
Repetitive Transcranial Magnetic Stimulation of the Dorsolateral Prefrontal Cortex for Phantom Limb Pain.
Source: Pain Physician 2024 Jul; 27(5). Authors: Vats D, Bhatia R, Fatima S, Yadav R, Sagar S, Mir N, Khan MA, Singh A Phantom limb pain (PLP) is a prevalent and distressing occurrence in 60-80% of individuals who have undergone amputations. Recent research underscores the…
Mapping gut feelings and immune control.
Source: Science 2024 Aug 02; 385(6708). doi: 10.1126/science.adq9533Authors: Vergnolle N A chemogenetic screen reveals links between nociceptors and gut immune function. Pubmed ID: https://pubmed.ncbi.nlm.nih.gov/39088639/
Discovery of Novel, Selective, and Nonbasic Agonists for the Kappa-Opioid Receptor Determined by Salvinorin A-Based Virtual Screening.
Source: J Med Chem 2024 Aug 01; . doi: 10.1021/acs.jmedchem.4c00590Authors: Puls K, Olivé-Marti AL, Hongnak S, Lamp D, Spetea M, Wolber G Modulating the kappa-opioid receptor (KOR) is a promising strategy for treating various human diseases. KOR agonists show potential for treating pain, pruritus, and…
Digital health technologies to strengthen patient-centred outcome assessment in clinical trials in inflammatory arthritis.
Source: Lancet Rheumatol 2024 Jul 29; . doi: 10.1016/S2665-9913(24)00186-3Authors: McGagh D, Song K, Yuan H, Creagh AP, Fenton S, Ng WF, Goldsack JC, Dixon WG, Doherty A, Coates LC Common to all inflammatory arthritides, namely rheumatoid arthritis, psoriatic arthritis, axial spondyloarthritis, and juvenile idiopathic arthritis,…
Low-intensity focused ultrasound to the posterior insula reduces temporal summation of pain.
Source: Brain Stimul 2024 Jul 30; . doi: 10.1016/j.brs.2024.07.020Authors: In A, Strohman A, Payne B, Legon W The insula and dorsal anterior cingulate cortex (dACC) are core brain regions involved in pain processing and central sensitization, a shared mechanism across various chronic pain conditions. Methods…
Intra-articular sprouting of nociceptors accompanies progressive osteoarthritis: comparative evidence in four murine models.
Source: Front Neuroanat 2024; 18. doi: 10.3389/fnana.2024.1429124Authors: Obeidat AM, Ishihara S, Li J, Adamczyk NS, Lammlin L, Junginger L, Maerz T, Miller RJ, Miller RE, Malfait AM Knee joints are densely innervated by nociceptors. In human knees and rodent models, sprouting of nociceptors has been…
The roles of circular RNAs in nerve injury and repair.
Source: Front Mol Neurosci 2024; 17. doi: 10.3389/fnmol.2024.1419520Authors: Zong Y, Dai Y, Yan J, Yu B, Wang D, Mao S Nerve injuries significantly impact the quality of life for patients, with severe cases posing life-threatening risks. A comprehensive understanding of the pathophysiological mechanisms underlying nerve…