July 24-30, 2026
Showing 1-25 of 37.
Leukotriene B4 potentiates acid-sensing ion channel currents in mouse dorsal root ganglion neurons
Source: Neuropharmacology Authors: Fei Sun, Huan Yuan, Chen Wang, Beibei Du, Xue-Mei Li, Ting-Ting Liu, Chun-Yu Qiu, Wang-Ping Hu, Publication Date: Wed, 29 Jul 2026 06:00:00 -0400 Neuropharmacology. 2026 Jul 29:111125. doi: 10.1016/j.neuropharm.2026.111125. Online ahead of print. ABSTRACT Leukotriene B4 (LTB4) is a lipid mediator…
Involvement of the cannabinoid receptors of the basolateral amygdala in the orexin A-mediated modulation of the stress-induced analgesia
Source: Neuropharmacology Authors: Mahnaz Aghaei, Roghaieh Khakpay, Fatemeh Khakpai, Mohammadali Hosseinpour Feizi, Publication Date: Wed, 29 Jul 2026 06:00:00 -0400 Neuropharmacology. 2026 Jul 29:111126. doi: 10.1016/j.neuropharm.2026.111126. Online ahead of print. ABSTRACT The amygdala receives extensive projections from the dorsomedial and ventromedial hypothalamus (DMH and VMH),…
AAV-mediated overexpression of Prdm12 in knee-innervating afferents reduces inflammatory joint pain and neuronal hyperexcitability in female mice
Source: The Journal of neuroscience : the official journal of the Society for Neuroscience Authors: Maya Dannawi, Luke A Pattison, Alexander Cloake, Eric J Bellefroid, Ewan St John Smith, Publication Date: Tue, 28 Jul 2026 06:00:00 -0400 J Neurosci. 2026 Jul 28:e2065252026. doi: 10.1523/JNEUROSCI.2065-25.2026. Online…
Distinct neural modes carry information about attempted grasp timing and force in the sensorimotor cortex
Source: The Journal of neuroscience : the official journal of the Society for Neuroscience Authors: G H Blumenthal, B M Dekleva, C Gontier, I C Gonzalez, J A Gonzalez-Martinez, B M Yu, A P Batista, A R Sobinov, L E Miller, R A Gaunt, M…
Mesenchymal stem cell-extracellular vesicles deliver microRNAs that prevent nerve growth factor-induced sensory neuron sensitization
Source: The Journal of neuroscience : the official journal of the Society for Neuroscience Authors: Lanhui Qiu, Paula-Milan Rois, Tuğdem Muslu-Ufuk, Jonathan L Price, Alexander Cloake, Eric A Miska, Tim L Williams, Ewan St John Smith, Publication Date: Tue, 28 Jul 2026 06:00:00 -0400 J…
Spontaneous pain after nerve injury is linked to spontaneous activity in uninjured nociceptors that become insensitive to cutaneous stimulation
Source: Pain Authors: Edgar T Walters, Publication Date: Tue, 28 Jul 2026 06:00:00 -0400 Pain. 2026 Jul 27. doi: 10.1097/j.pain.0000000000004083. Online ahead of print. NO ABSTRACT PMID:42520167 | DOI:10.1097/j.pain.0000000000004083 Pubmed ID: pubmed:42520167 Identifiers: pmid:42520167, doi:10.1097/j.pain.0000000000004083,
In vivo GCaMP imaging reveals distinct subsets of dorsal root ganglion neurons driving spontaneous pain after nerve injury in mice
Source: Pain Authors: Leo C Guan, Jing Liu, Zhaoli Luo, Michael Jiang, Jun-Ming Zhang, Qin Zheng, Publication Date: Tue, 28 Jul 2026 06:00:00 -0400 Pain. 2026 Jul 28. doi: 10.1097/j.pain.0000000000004084. Online ahead of print. ABSTRACT Spontaneous pain is a hallmark and debilitating feature of neuropathic…
Anterior and posterior retrosplenial cortex employ distinct strategies for egocentric-allocentric transformation in spatial coding
Source: Proceedings of the National Academy of Sciences of the United States of America Authors: Youran Yang, Xiang Zhang, Xin Yuan, Haiqian Cai, Qichen Cao, Chenglin Miao, Publication Date: Tue, 28 Jul 2026 06:00:00 -0400 Proc Natl Acad Sci U S A. 2026 Aug 4;123(31):e2600565123….
Central role for fast nociceptors in mechanical nocifensive behavior and sensitization
Source: Nature communications Authors: John Chwen-Yu Chen, Oumie Thorell, Felipe Meira de-Faria, Aikeremu Ahemaiti, Olivia Le Moëne, Lech Kaczmarczyk, Katharina Henriksson, Jonathan Cole, David A Mahns, Håkan Olausson, Walker S Jackson, Saad S Nagi, Malin C Lagerström, Marcin Szczot, Max Larsson, Publication Date: Sat, 25…
LPA/LPAR signaling drives temporomandibular disorders-like pain through regulating the expression and sensitization of PIEZO2
Source: Science advances Authors: Qiaojuan Zhang, Shanchun Su, Pengfei Liang, Yun Chen, Minseok Kim, Robert Baldi, Peng Wang, Fabiana C Dias, Minji Jang, Maria A Gonzalez Torres, Peifeng Lim, Roger W F Moreira, Jerold Chun, Farshid Guilak, Huanghe Yang, Wolfgang Liedtke, Andrea Nackley, Yong Chen,…
Beyond distal arthrogryposis: refining the phenotypic landscape of PIEZO2-related disorders
Source: Brain : a journal of neurology Authors: Giuliana Capece, Maria Francesca Di Feo, Evgeniya Melnik, Elena Dadali, Tatiana Markova, Alain Verloes, Federica Ruscitti, Jonathan Lévy, Daniel Natera-de Benito, Carlos Ortez, Andres Nascimiento, Berta Estevez-Arias, Cristina Jou, Sergei Kurbatov, Aysylu Murtazina, Artem Sharkov, Nour Elkhateeb,…
Sex differences in somatosensory circuitry are programmed by developmental microglia-astrocyte interaction
Source: Cell reports Authors: Abigayle Duffy, Leigh Ellen Fremuth, Madison Doceti, JaQuinta Thomas, Charlotte Buswell, Osaretin Lawani, John R Lukens, Ukpong B Eyo, Publication Date: Sat, 25 Jul 2026 06:00:00 -0400 Cell Rep. 2026 Jul 25;45(8):117709. doi: 10.1016/j.celrep.2026.117709. Online ahead of print. ABSTRACT Men possess…
Peripheral ASIC1a regulation in an LPS-induced inflammatory pain model
Source: Neuropharmacology Authors: Mayra Micaela Montes, Libia Catalina Salinas Castellanos, Juan Santiago Guidobono, Mariela Lacave, Romina De Lucca, Carina Weissmann, Publication Date: Mon, 27 Jul 2026 06:00:00 -0400 Neuropharmacology. 2026 Jul 27:111119. doi: 10.1016/j.neuropharm.2026.111119. Online ahead of print. ABSTRACT Animal models of inflammatory pain frequently…
Inward rectifier potassium channels interact with calcium channels to promote robust and physiological bistability
Source: PLoS computational biology Authors: De Worm Anaëlle, Drion Guillaume, Sacré Pierre, Publication Date: Tue, 28 Jul 2026 06:00:00 -0400 PLoS Comput Biol. 2026 Jul 28;22(7):e1014549. doi: 10.1371/journal.pcbi.1014549. Online ahead of print. ABSTRACT Projection neurons in the dorsal horn relay nociceptive input to supraspinal centers….
Lipids drive chronic sickle cell disease pain
Source: Blood Authors: Katelyn E Sadler, Publication Date: Wed, 22 Jul 2026 06:00:00 -0400 Blood. 2026 Jul 30;148(5):532-533. doi: 10.1182/blood.2026034092. NO ABSTRACT PMID:42486805 | DOI:10.1182/blood.2026034092 Pubmed ID: pubmed:42486805 Identifiers: pmid:42486805, doi:10.1182/blood.2026034092,
A central amygdala-locus coeruleus pathway mediating pain under chronic stress
Source: Cell reports Authors: Jing Wei, An Liu, Yu Cao, Jia-Meng Fang, Qian Chen, Jing Ma, Xia Zhu, Zhi Zhang, Zi-Hua Song, Qian Meng, Publication Date: Thu, 18 Jun 2026 06:00:00 -0400 Cell Rep. 2026 Jul 28;45(7):117570. doi: 10.1016/j.celrep.2026.117570. Epub 2026 Jun 18. ABSTRACT Chronic…
Chronic pain in sickle cell disease: a role for lysophosphatidic acid
Source: Blood Authors: Viacheslav Viatchenko-Karpinski, Iryna A Khasabova, Malcolm Johns, Laura Neal, Kathy Tang, Mikhail Y Golovko, Alina M Golovko, Summbla Anjum, Kalpna Gupta, Sergey G Khasabov, Donald A Simone, Publication Date: Wed, 13 May 2026 06:00:00 -0400 Blood. 2026 Jul 30;148(5):623-633. doi: 10.1182/blood.2025031738. ABSTRACT…
The genetics of fibromyalgia and its relationships to psychiatric and medical traits
Source: Nature communications Authors: Uri Bright, Sarah Beck, Daniel F Levey, Joseph D Deak, VA Million Veteran Program, J Michael Gaziano, Murray B Stein, Joel Gelernter, Publication Date: Tue, 28 Jul 2026 06:00:00 -0400 Nat Commun. 2026 Jul 28;17(1):6248. doi: 10.1038/s41467-026-75256-6. ABSTRACT We explore the…
The genetic architecture of fibromyalgia across 2.5 million individuals
Source: Nature medicine Authors: Isabel Kerrebijn, Gyda Bjornsdottir, Keon Arbabi, Lea Urpa, Hele Haapaniemi, Gudmar Thorleifsson, Lilja Stefansdottir, Stephan Frangakis, Jesse Valliere, Lovemore Kunorozva, Erik Abner, Caleb Ji, Markus Kangur, Bitten Aagaard, Henning Bliddal, Søren Brunak, Mie T Bruun, Maria Didriksen, Christian Erikstrup, Sarah Finer,…
Phase 2b Trial of a Na(V)1.8 Inhibitor for Acute Pain
Source: The New England journal of medicine Authors: Neil Singla, Nathaniel P Katz, Ben Vaughn, Timothy Rogier, Todd Bertoch, Harold Minkowitz, Mallory Loflin, Publication Date: Wed, 29 Jul 2026 06:00:00 -0400 N Engl J Med. 2026 Jul 30;395(5):454-464. doi: 10.1056/NEJMoa2602910. ABSTRACT BACKGROUND: Nav1.8, a voltage-gated…
Electrostatic tuning of NaV channel activation by the domain II S3-S4 extracellular loop
Source: The Journal of physiology Authors: Ashvriya Thapa, Lotten Ragnarsson, Hue Tran, Angelo Keramidas, Jennifer R Deuis, Irina Vetter, Publication Date: Sat, 25 Jul 2026 06:00:00 -0400 J Physiol. 2026 Jul 25. doi: 10.1113/JP291286. Online ahead of print. ABSTRACT How NaV channel isoforms set their…
When less function does not mean less pain
Source: Pain Authors: Margarita Calvo, Publication Date: Mon, 27 Jul 2026 06:00:00 -0400 Commentary on Schottmann et al. this issue. Pain. 2026 Jul 24. doi: 10.1097/j.pain.0000000000004077. Online ahead of print. NO ABSTRACT PMID:42505241 | DOI:10.1097/j.pain.0000000000004077 Pubmed ID: pubmed:42505241 Identifiers: pmid:42505241, doi:10.1097/j.pain.0000000000004077,
Peripheral pain threshold, glycaemic status, and LAMP3 genetic variation: A community-based analysis
Source: Neurobiology of disease Authors: Hidefumi Ruike, Hiroki Mizukami, Zhenchao Wang, Hanae Kushibiki, Mizuri Ishida, Sho Osonoi, Takefusa Tarusawa, Takanori Sasaki, Tu Yi, Saori Ogasawara, Akiko Itaya, Atsumi Abe, Gentaro Kumagai, Yoshinori Tamada, Yukihiro Fujita, Tatsuya Mikami, Ken Itoh, Yasuyuki Ishibashi, Kenichi Hakamada, Koich Murashita,…
Migraine in the cradle of civilization: Evaluating ancient Mesopotamian texts through the lens of ICHD-3
Source: Headache Authors: Bulent Diri, Bilge Piri Cinar, Zeynep Sena Diri, Okan Bolukbasi, Peter J Goadsby, Aynur Ozge, Publication Date: Wed, 29 Jul 2026 06:00:00 -0400 Headache. 2026 Jul 28. doi: 10.1111/head.70172. Online ahead of print. ABSTRACT BACKGROUND: Migraine is a neurological disorder with well-established…
Modelling the memory of unmyelinated axons: Integration of a data-driven approach with physiological memory concept
Source: The Journal of physiology Authors: Anna Maxion, Jenny Tigerholm, Barbara Namer, Ekaterina Kutafina, Publication Date: Wed, 29 Jul 2026 06:00:00 -0400 J Physiol. 2026 Jul 29. doi: 10.1113/JP290729. Online ahead of print. ABSTRACT This study aims to present a simplified and resource-efficient computational model…