January 18-24, 2025
Showing 1-25 of 119.
Neuronal mechanisms of nociceptive-evoked gamma-band oscillations in rodents
Source: Neuron 2025 Jan 13;. doi: https://doi.org/10.1016/j.neuron.2024.12.011 Authors: Lupeng Yue, Chongyu Bao, Libo Zhang, Fengrui Zhang, Wenqian Zhou, Gian Domenico Iannetti, Li Hu Gamma-band oscillations (GBOs) in the primary somatosensory cortex (S1) play key roles in nociceptive processing. Yet, one crucial question remains unaddressed: what…
How spinal GABAergic circuits modulate cerebral processing of postsurgical pain.
Source: Pharmacol Res 2025 Jan 16;. doi: 10.1016/j.phrs.2025.107609 Authors: Pradier B, Segelcke D, Just N, Augustin M, Nagelmann N, Faber C, Pogatzki-Zahn E Post-surgical pain affects millions each year, hindering recovery and quality of life. Surgical procedures cause tissue damage and inflammation, leading to peripheral…
An atlas of neuropathic pain-associated molecular pathological characteristics in the mouse spinal cord.
Source: Commun Biol 2025 Jan 17; 8(1). doi: 10.1038/s42003-025-07506-0 Authors: Dong FL, Yu L, Feng PD, Ren JX, Bai XH, Lin JQ, Cao DL, Deng YT, Zhang Y, Shen HH, Gong H, Sun WX, Chi DQ, Mei Y, Ma L, Yin MZ, Li MN, Zhang…
A septo-hypothalamic-medullary circuit directs stress-induced analgesia.
Source: Elife 2025 Jan 20; 13. doi: 10.7554/eLife.96724Authors: Shah DP, Sharma PR, Agarwal R, Barik A Stress is a potent modulator of pain. Specifically, acute stress due to physical restraint induces stress-induced analgesia (SIA). However, where and how acute stress and pain pathways interface in…
Two-year outcomes using fast-acting sub-perception therapy for spinal cord stimulation: results of a real-world multicenter study in the United States.
Source: Expert Rev Med Devices 2025 Jan 16; . doi: 10.1080/17434440.2025.2453554Authors: Metzger C, Hammond B, Ferro R, North J, Pyles S, Kranenburg A, Washabaugh E, Goldberg E Fast-acting Sub-perception Therapy (FAST) is a novel spinal cord stimulation (SCS) modality delivering paresthesia-free pain relief. Our study…
Assessing pain in multiple sclerosis: Test-retest reliability of patient-reported outcome measures and accuracy of screening tools.
Source: Mult Scler 2025 Jan 16; . doi: 10.1177/13524585241310139Authors: Yilmazer C, D’haeseleer M, Soler B, Van Wijmeersch B, Solaro C, Ciampi E, Carcamo C, Van Asch P, Cambron M, Lamers I, Feys P Pain is a common symptom of multiple sclerosis (MS). The reliability of…
Not Just a Pelvic Problem: Endometriosis is linked to migraines, asthma, and more.
Source: Sci Am 2025 Feb 01; 332(2). doi: 10.1038/scientificamerican022025-1H75jKuh3yIbPbGBAjeCrFAuthors: Denworth L Pubmed ID: https://pubmed.ncbi.nlm.nih.gov/39836592/
Sex and age effects on chronic inflammatory pain development, maintenance, and resolution in Wistar rats.
Source: J Pain 2025 Jan 20; . doi: 10.1016/j.jpain.2025.104789Authors: Jones AF, Wang Q, Rodríguez-Graciani KM, Díaz Z, Simon L, Gilpin NW Millions of Americans live with chronic inflammatory pain conditions, and the prevalence of these conditions increases with age and is higher in females. Still,…
Characterisation of periorbital mechanical allodynia in the reserpine-induced fibromyalgia model in mice: The role of the Schwann cell TRPA1/NOX1 signalling pathway.
Source: Free Radic Biol Med 2025 Jan 20; . doi: 10.1016/j.freeradbiomed.2025.01.040Authors: da Silva Brum E, Landini L, Monteiro de Araújo DS, Marini M, Geppetti P, Nassini R, De Logu F, Oliveira SM Fibromyalgia (FM) is a complex and multifaceted condition characterized by a range of…
Application of Self-Healing Hydrogels in the Treatment of Intervertebral Disc Degeneration.
Source: J Biomed Mater Res B Appl Biomater 2025 Feb; 113(2). doi: 10.1002/jbm.b.35532Authors: Guo C, Jiao X, Du X, Zhang T, Peng B, Xu B Intervertebral disc degeneration (IDD) is one of the leading causes of chronic pain and disability, and traditional treatment methods often…
Neurochemical mechanism of muscular pain: Insight from the study on delayed onset muscle soreness.
Source: J Physiol Sci 2024; 74(1). doi: 10.1186/s12576-023-00896-yAuthors: Mizumura K, Taguchi T We reviewed fundamental studies on muscular pain, encompassing the characteristics of primary afferent fibers and neurons, spinal and thalamic projections, several muscular pain models, and possible neurochemical mechanisms of muscle pain. Most parts…
NaHS modulates astrocytic EAAT2 expression to impact SNI-induced neuropathic pain and depressive-like behaviors.
Source: Sci Rep 2025 Jan 22; 15(1). doi: 10.1038/s41598-025-86885-0Authors: Qi MM, Peng HY, Zhang TG, Li Y, Gao MY, Sun WB, Wang XP The potential role of hydrogen sulfide (HS) in the modulation of neuropathic pain is increasingly recognized. This study investigated the therapeutic effect…
Identification of hub biomarkers and immune cell infiltrations participating in the pathogenesis of endometriosis.
Source: Sci Rep 2025 Jan 22; 15(1). doi: 10.1038/s41598-025-86164-yAuthors: Li K, Wang J, Liu X, Dang Y, Wang K, Li M, Zhang X, Liu Y Endometriosis (EM) is a chronic disease that can cause pain and infertility in patients. As is well known, immune cell…
Development of the Migraine-Related Stigma (MiRS) Questionnaire: Results of the OVERCOME (US) Study.
Source: Headache 2025 Jan 22; . doi: 10.1111/head.14886Authors: Seng EK, Muenzel EJ, Shapiro RE, Buse DC, Reed ML, Zagar AJ, Ashina S, Hutchinson S, Nicholson RA, Lipton RB Stigma is emerging as an important social contributor to migraine-related disability and other outcomes. Currently, there are…
CD34hi subset of synovial fibroblasts contributes to fibrotic phenotype of human knee osteoarthritis.
Source: JCI Insight 2025 Jan 23; 10(2). doi: 10.1172/jci.insight.183690Authors: Miyahara J, Omata Y, Chijimatsu R, Okada H, Ishikura H, Higuchi J, Tachibana N, Nagata K, Tani S, Kono K, Kawaguchi K, Yamagami R, Inui H, Taketomi S, Iwanaga Y, Terashima A, Yano F, Seki M,…
Today in headache medicine: Helpful analogies in headache medicine.
Source: Headache 2025 Jan 23; . doi: 10.1111/head.14898Authors: Tandon M, Moran H, Starling AJ, VanderPluym JH Pubmed ID: https://pubmed.ncbi.nlm.nih.gov/39846344/
A Review of Leveraging Artificial Intelligence to Predict Persistent Postoperative Opioid Use and Opioid Use Disorder and its Ethical Considerations.
Source: Curr Pain Headache Rep 2025 Jan 23; 29(1). doi: 10.1007/s11916-024-01319-2Authors: Gabriel RA, Park BH, Hsu CN, Macias AA Artificial intelligence (AI) offers a new frontier for aiding in the management of both acute and chronic pain, which may potentially transform opioid prescribing practices and…
Weathering the Pain: Ambient Temperature’s Role in Chronic Pain Syndromes.
Source: Curr Pain Headache Rep 2025 Jan 23; 29(1). doi: 10.1007/s11916-025-01361-8Authors: Jevotovsky DS, Oehlermarx W, Chen T, Ortiz CC, Liu A, Sahni S, Kessler JL, Poli JJ, Lau R Chronic pain is highly prevalent and involves a complex interaction of sensory, emotional, and cognitive processes,…
Painful diabetic neuropathy is associated with accelerated epigenetic aging.
Source: Geroscience 2025 Jan 23; . doi: 10.1007/s11357-025-01516-wAuthors: Kwiatkowska KM, Garagnani P, Bonafé M, Bacalini MG, Calzari L, Gentilini D, Ziegler D, Gerrits MM, Faber CG, Malik RA, Marchi M, Salvi E, Lauria G, Pirazzini C About one out of two diabetic patients develop diabetic…
The concept of difficult-to-treat disease in rheumatology: where next?
Source: Lancet Rheumatol 2025 Jan 20; . doi: 10.1016/S2665-9913(24)00340-0Authors: Nagy G, Gunkl-Tóth L, Dorgó AM, McInnes IB New pathogenesis-based therapeutics and evidence-based consensus treatment recommendations, often with predefined treatment goals, have remarkably improved outcomes across many chronic diseases. However, a clinically significant subgroup of patients…
Glutamate transporter activator LDN-212320 prevents chronic pain-induced cognitive impairment and anxiety-like behaviors in a mouse model.
Source: Behav Brain Res 2025 Jan 21; . doi: 10.1016/j.bbr.2025.115440Authors: Alotaibi G, Khan A, Rahman S The astroglial glutamate transporter in the hippocampus and anterior cingulate cortex (ACC) is critically involved in chronic pain-induced cognitive and psychiatric abnormalities. We have previously reported that LDN-212320, a…
Sprouting sympathetic fibres release CXCL16 and norepinephrine to synergistically mediate sensory neuronal hyperexcitability in a rodent model of neuropathic pain.
Source: Br J Anaesth 2025 Jan 22; . doi: 10.1016/j.bja.2024.10.019Authors: Wang C, Di A, Wu Y, Liu M, Wei M, Liang Z, Liu F, Fan H, Dong B, Li C, Xu T, Xin W, Feng X Chronic neuropathic pain generally has a poor response to…
The relationship between cannabis and cardiovascular disease: clearing the haze.
Source: Nat Rev Cardiol 2025 Jan 23; . doi: 10.1038/s41569-025-01121-6Authors: Chandy M, Jimenez-Tellez N, Wu JC Cannabis has been consumed for centuries, but global regulatory changes over the past three decades have increased the availability and consumption of cannabis. Cannabinoids are touted to have therapeutic…
Efficacy of repetitive transcranial magnetic stimulation for phantom limb pain- a meta analysis of randomized controlled trials.
Source: Neurol Sci 2025 Jan 23; . doi: 10.1007/s10072-025-08016-xAuthors: Chandni F, Savanti F, Kumar R, Raj M, Kumar A, Kumar A, Kinger S, Kumar S, Rai H, Shaik AA, Asghar MS Phantom limb pain (PLP) is a neuropathic syndrome experienced by the majority of amputees….
Inactivated SARS-CoV-2 induces acute skeletal muscle damage in human K18-hACE2 transgenic mice.
Source: Life Sci 2025 Jan 18; . doi: 10.1016/j.lfs.2025.123404Authors: de Souza ALG, da Silva Rosa Alves AL, de Sousa JC, Barbosa NC, Rodrigues FC, Santos SACS, de Oliveira TS, Temerozo JR, Bou-Habib DC, Takiya CM, de Azevedo Canetti C, Benjamim CF, Coutinho-Silva R, Kurtenbach E…