February 3-9, 2024
Showing 1-25 of 99.
Sensory Schwann cells set perceptual thresholds for touch and selectively regulate mechanical nociception.
Source: Nat Commun 2024 Feb 06; 15(1). doi: 10.1038/s41467-024-44845-8 Authors: Ojeda-Alonso J, Calvo-Enrique L, Paricio-Montesinos R, Kumar R, Zhang MD, Poulet JFA, Ernfors P, Lewin GR Previous work identified nociceptive Schwann cells that can initiate pain. Consistent with the existence of inherently mechanosensitive sensory Schwann…
Nociceptive, neuropathic, or nociplastic low back pain? The low back pain phenotyping (BACPAP) consortium’s international and multidisciplinary consensus recommendations.
Source: Lancet Rheumatol 2024 Feb 01;. doi: 10.1016/S2665-9913(23)00324-7 Authors: Nijs J, Kosek E, Chiarotto A, Cook C, Danneels LA, Fernández-de-Las-Peñas C, Hodges PW, Koes B, Louw A, Ostelo R, Scholten-Peeters GGM, Sterling M, Alkassabi O, Alsobayel H, Beales D, Bilika P, Clark JR, De Baets…
METTL14-mediated m6A epitranscriptomic modification contributes to chemotherapy-induced neuropathic pain by stabilizing GluN2A expression via IGF2BP2.
Source: J Clin Invest 2024 Feb 06;. doi: 10.1172/JCI174847 Authors: Lu W, Yang X, Zhong W, Chen G, Guo X, Ye Q, Xu Y, Qi Z, Ye Y, Zhang J, Wang Y, Wang X, Wang S, Zhao Q, Zeng W, Huang J, Ma H, Xie…
GPR39 regulated spinal glycinergic inhibition and mechanical inflammatory pain.
Source: Sci Adv 2024 Feb 02; 10(5). doi: 10.1126/sciadv.adj3808 Authors: Bai HH, Wang KL, Zeng XR, Li J, Li Y, Xu JY, Zhang Y, Jiang HF, Yang X, Suo ZW, Hu XD G protein-coupled receptor 39 (GPR39) senses the change of extracellular divalent zinc ion…
Incidence and risk factors for developing chemotherapy-induced neuropathic pain in 500 cancer patients: A file-based observational study.
Source: J Peripher Nerv Syst 2024 Feb 04; . doi: 10.1111/jns.12616Authors: Argyriou AA, Bruna J, Kalofonou F, Velasco R, Litsardopoulos P, Alemany M, Anastopoulou GG, Kalofonos HP To define the incidence and risk factors for developing chemotherapy-induced neuropathic pain (CINP). Pubmed ID: https://pubmed.ncbi.nlm.nih.gov/38311337/
Molecular and cellular pruritus mechanisms in the host skin.
Source: Exp Mol Pathol 2024 Feb 03; . doi: 10.1016/j.yexmp.2024.104889Authors: Li L, Li ZE, Mo YL, Li WY, Li HJ, Yan GH, Qin XZ, Piao LH Pruritus, also known as itching, is a complex sensation that involves the activation of specific physiological and cellular receptors….
Sex differences in carbamazepine effects in a rat model of trigeminal neuropathic pain.
Source: Eur J Pharmacol 2024 Feb 02; . doi: 10.1016/j.ejphar.2024.176386Authors: Baggio DF, da Luz FMR, Zortea JM, Lejeune VBP, Chichorro JG Carbamazepine (CBZ) represents the first-line treatment for trigeminal neuralgia, a condition of facial pain that affects mainly women. The chronic constriction of the infraorbital…
Involvement of peripheral mast cells in a fibromyalgia model in mice.
Source: Eur J Pharmacol 2024 Feb 02; . doi: 10.1016/j.ejphar.2024.176385Authors: Silva Brum ED, Fialho MFP, Becker G, Nogueira CW, Oliveira SM Fibromyalgia is a painful disorder of unknown aetiology that presents activation and recruitment of innate immune cells, including mast cells. Efforts have been made…
Has a hundred years of pursuing proteases helped to palliate pain in chronic pancreatitis more than placebo?
Source: Gastroenterology 2024 Feb 02; . doi: 10.1053/j.gastro.2024.01.039Authors: Singh VP, Gorelick FS Pubmed ID: https://pubmed.ncbi.nlm.nih.gov/38311123/
ASSOCIATIONS OF INFLAMMATORY AND METABOLIC BIOMARKERS WITH INCIDENT EROSIVE HAND OSTEOARTHRITIS IN THE OSTEOARTHRITIS INITIATIVE COHORT.
Source: Osteoarthritis Cartilage 2024 Feb 02; . doi: 10.1016/j.joca.2023.10.011Authors: McAlindon TE, Hunnicutt JL, Roberts MB, Haugen IK, Schaefer LF, Driban JB, Lu B, Duryea J, Smith SE, Booth SL, Petty GA, Mathiessen A, Zeng L, Eaton C Erosive hand osteoarthritis (eHOA) is a subtype of…
Psychologically-based interventions for adults with chronic neuropathic pain: A scoping review.
Source: Pain Med 2024 Feb 04; . doi: 10.1093/pm/pnae006Authors: Oguchi M, Nicholas MK, Asghari A, Sanders D, Wrigley PJ As psychologically-based interventions have been shown to have clinical utility for adults with chronic pain generally, a similar benefit might be expected in the management of…
Heightened Interoception in Adults with Fibromyalgia.
Source: Biol Psychol 2024 Feb 01; . doi: 10.1016/j.biopsycho.2024.108761Authors: Todd J, Plans D, Lee MC, Bird JM, Morelli D, Cunningham A, Ponzo S, Murphy J, Bird G, Aspell JE Previous research suggests that the processing of internal body sensations (interoception) affects how we experience pain….
Small molecules modified mesoporous silica nanoparticles orally deliver indomethacin with synergistic effect.
Source: Eur J Pharm Sci 2024 Feb 01; . doi: 10.1016/j.ejps.2024.106719Authors: Yin S, Cai L, Li X, Lin K, Shi X, Zhang H, Wang L, Li J Molecularly functional drug delivery systems possessed huge potentials to realize novel drug administration. To explore small molecules modified…
Astrocytic Na, K ATPases in physiology and pathophysiology.
Source: Cell Calcium 2024 Jan 28; 118. doi: 10.1016/j.ceca.2024.102851Authors: Pietrobon D, Conti F The Na, K ATPases play a fundamental role in the homeostatic functions of astrocytes. After a brief historic prologue and discussion of the subunit composition and localization of the astrocytic Na, K…
Patented farnesoid X receptor modulators: a review (2019 – present).
Source: Expert Opin Ther Pat 2024 Feb 03; . doi: 10.1080/13543776.2024.2314296Authors: Gioiello A, Rosatelli E, Cerra B The Farnesoid X receptor (FXR) is a key transcription factor that is involved in the bile acid signaling network. The modulation of the FXR activity influences glucose and…
Breast milk oxycodone concentrations in mothers given oxycodone for post-Caesarean delivery pain management.
Source: Br J Clin Pharmacol 2024 Feb 02; . doi: 10.1111/bcp.16008Authors: Pesonen A, Hakomäki H, Kokki H, Ranta VP, Rinne V, Kokki M Both effective analgesia and early breastfeeding play an important role in maternal and neonatal well-being after Caesarean delivery. We studied controlled-release oxycodone…
Habitual caffeinated beverage consumption and headaches among adults with episodic migraine: A prospective cohort study.
Source: Headache 2024 Feb 06; . doi: 10.1111/head.14673Authors: Mittleman MR, Mostofsky E, Vgontzas A, Bertisch SM To examine the relationship between habitual caffeinated beverage consumption and headache frequency, duration, and intensity in a prospective cohort of adults with episodic migraine. Pubmed ID: https://pubmed.ncbi.nlm.nih.gov/38318677/
Modulation of pain perception through transcranial alternating current stimulation and its nonlinear relationship with the simulated electric field magnitude.
Source: Eur J Pain 2024 Feb 06; . doi: 10.1002/ejp.2249Authors: Ikarashi H, Otsuru N, Gomez-Tames J, Hirata A, Nagasaka K, Miyaguchi S, Sakurai N, Ohno K, Kodama N, Onishi H Oscillatory activities observed in multiple regions are closely associated with the experience of pain. Specifically,…
Familial effects account for association between chronic pain and past month smoking.
Source: Eur J Pain 2024 Feb 06; . doi: 10.1002/ejp.2247Authors: Rader L, Reineberg AE, Petre B, Wager TD, Friedman NP Smoking is associated with chronic pain, but it is not established whether smoking causes pain or if the link is due to familial effects. One…
Economic evaluation of management strategies for complex regional pain syndrome (CRPS).
Source: Front Pharmacol 2024; 15. doi: 10.3389/fphar.2024.1297927Authors: Zhou X, Zhou Y, Zhang X, Jiang F The economic impact of Complex Regional Pain Syndrome (CRPS) on both patients and the global healthcare system continues to escalate. However, the economic implications associated with management interventions for CRPS…
J-2156, a small molecule somatostatin type 4 receptor agonist, alleviated hindpaw hypersensitivity in the streptozotocin-induced rat model of painful diabetic neuropathy but with a 2-fold decrease in potency at an advanced stage in the model, mimicking morphine.
Source: Front Pharmacol 2024; 15. doi: 10.3389/fphar.2024.1346801Authors: Kuo A, Imam MZ, Li R, Lin L, Raboczyj A, Bohmer AE, Nicholson JR, Corradini L, Smith MT There is a large unmet need for novel pain-killers to improve relief of painful diabetic neuropathy (PDN). Herein, we assessed…
How migraine and its associated treatment impact on pregnancy outcomes: Umbrella review with updated systematic review and meta-analysis.
Source: Cephalalgia 2024 Feb; 44(2). doi: 10.1177/03331024241229410Authors: Phillips K, Clerkin-Oliver C, Nirantharakumar K, Crowe FL, Wakerley BR Migraine is common in reproductive aged women. Understanding the impact of migraine and associated treatments on pregnancy outcomes remains very important. An umbrella review of systematic reviews, with…
Dynamic changes in glymphatic function in reversible cerebral vasoconstriction syndrome.
Source: J Headache Pain 2024 Feb 05; 25(1). doi: 10.1186/s10194-024-01726-1Authors: Wu CH, Kuo Y, Ling YH, Wang YF, Fuh JL, Lirng JF, Wu HM, Wang SJ, Chen SP The pathophysiology of the reversible cerebral vasoconstriction syndrome (RCVS) remains enigmatic and the role of glymphatics in…
Nucleus pulposus cells regulate macrophages in degenerated intervertebral discs via the integrated stress response-mediated CCL2/7-CCR2 signaling pathway.
Source: Exp Mol Med 2024 Feb 05; . doi: 10.1038/s12276-024-01168-4Authors: Tian S, Chen X, Wu W, Lin H, Qing X, Liu S, Wang B, Xiao Y, Shao Z, Peng Y Lower back pain (LBP), which is a primary cause of disability, is largely attributed to…
FSTL1 Accelerates Nucleus Pulposus Cell Senescence and Intervertebral Disc Degeneration Through TLR4/NF-κB Pathway.
Source: Inflammation 2024 Feb 06; . doi: 10.1007/s10753-024-01972-0Authors: Yan X, Ding JY, Zhang RJ, Zhang HQ, Kang L, Jia CY, Liu XY, Shen CL Intervertebral disc degeneration (IVDD) is a major contributor to low back pain (LBP), and inflammatory factors play crucial roles in its…