February 25 - March 3, 2023
Showing 1-25 of 137.
A photoswitchable inhibitor of TREK channels controls pain in wild-type intact freely moving animals.
Source: Nat Commun 2023 Mar 01; 14(1). doi: 10.1038/s41467-023-36806-4 Authors: Landra-Willm A, Karapurkar A, Duveau A, Chassot AA, Esnault L, Callejo G, Bied M, Häfner S, Lesage F, Wdziekonski B, Baron A, Fossat P, Marsollier L, Gasull X, Boué-Grabot E, Kienzler MA, Sandoz G By…
Up-regulation of HCN2 channels in a thalamocortical circuit mediates allodynia in mice.
Source: Natl Sci Rev 2023 Feb; 10(2). doi: 10.1093/nsr/nwac275 Authors: Yu JM, Hu R, Mao Y, Tai Y, Qun S, Zhang Z, Chen D, Jin Y Chronic pain is a significant problem that afflicts individuals and society, and for which the current clinical treatment is…
An analgesic pathway from parvocellular oxytocin neurons to the periaqueductal gray in rats.
Source: Nat Commun 2023 Feb 24; 14(1). doi: 10.1038/s41467-023-36641-7 Authors: Iwasaki M, Lefevre A, Althammer F, Clauss Creusot E, Łąpieś O, Petitjean H, Hilfiger L, Kerspern D, Melchior M, Küppers S, Krabichler Q, Patwell R, Kania A, Gruber T, Kirchner MK, Wimmer M, Fröhlich H,…
Cognitive therapy, mindfulness-based stress reduction, and behavior therapy for people with chronic low back pain: A comparative mechanisms study.
Source: J Consult Clin Psychol 2023 Feb 27; . doi: 10.1037/ccp0000801Authors: Burns JW, Jensen MP, Gerhart J, Thorn BE, Lillis TA, Carmody J, Keefe F Cognitive therapy (CT), mindfulness-based stress reduction (MBSR), and behavior therapy (BT) for chronic pain treatment produce outcome improvements. Evidence also…
Effectiveness of patient education plus motor control exercise versus patient education alone versus motor control exercise alone for rural community-dwelling adults with chronic low back pain: a randomised clinical trial.
Source: BMC Musculoskelet Disord 2023 Feb 23; 24(1). doi: 10.1186/s12891-022-06108-9Authors: Ibrahim AA, Akindele MO, Ganiyu SO Chronic low back pain (CLBP) is a common health problem in rural Nigeria but access to rehabilitation is limited. Current clinical guidelines unanimously recommend patient education (PE) including instruction…
Crossing the Rubicon? The future impact of artificial intelligence on headache medicine.
Source: Cephalalgia 2023 Apr; 43(4). doi: 10.1177/03331024231157379Authors: Peng KP, May A Pubmed ID: https://pubmed.ncbi.nlm.nih.gov/36855899/
An altered reward system characterizes chronic migraine with medication overuse headache.
Source: Cephalalgia 2023 Apr; 43(4). doi: 10.1177/03331024231158088Authors: Niddam DM, Wu SW, Lai KL, Yang YY, Wang YF, Wang SJ Medication overuse headache shares several characteristics with substance use disorders. However, key features of substance use disorders such as increased impulsivity and alterations in reward processing…
Safety profile of monoclonal antibodies targeting the calcitonin gene-related peptide system in pregnancy: Updated analysis in VigiBase®.
Source: Cephalalgia 2023 Apr; 43(4). doi: 10.1177/03331024231158083Authors: Noseda R, Bedussi F, Gobbi C, Ceschi A, Zecca C Safety data on the use of migraine preventive monoclonal antibodies targeting the calcitonin gene-related peptide (CGRP) system in pregnancy are limited. Pubmed ID: https://pubmed.ncbi.nlm.nih.gov/36855950/
Evaluating the efficacy of CGRP mAbs and gepants for the preventive treatment of migraine: A systematic review and network meta-analysis of phase 3 randomised controlled trials.
Source: Cephalalgia 2023 Apr; 43(4). doi: 10.1177/03331024231159366Authors: Haghdoost F, Puledda F, Garcia-Azorin D, Huessler EM, Messina R, Pozo-Rosich P Several novel treatments targeting the calcitonin gene-related peptide pathway have been developed for migraine. We evaluated the efficacy of these medications, including atogepant, rimegepant, erenumab, eptinezumab,…
The Global Campaign Against Headache and its future relation to IHS and WHO.
Source: Cephalalgia 2023 Apr; 43(4). doi: 10.1177/03331024231159625Authors: Olesen J, Jensen RH Preparations for the Global Campaign Against Headache done jointly with WHO started almost 25 years ago. It was officially incorporated 18 years ago. It is the story of a few dedicated individuals who, together…
Randomized controlled studies evaluating Topiramate, Botulinum toxin type A, and mABs targeting CGRP in patients with chronic migraine and medication overuse headache: A systematic review and meta-analysis.
Source: Cephalalgia 2023 Apr; 43(4). doi: 10.1177/03331024231156922Authors: Giri S, Tronvik E, Linde M, Pedersen SA, Hagen K This systematic review focuses on chronic migraine patients with medication overuse headache using, respectively, topiramate, botulinum toxin type A, and human monoclonal antibodies targeting calcitonin gene-related peptide or…
Chronic pain and premature mortality in men and women, using data from UK Biobank.
Source: J Clin Invest 2023 Mar 01; 133(5). doi: 10.1172/JCI166949Authors: Macfarlane GJ, Beasley M, Jones GT Pubmed ID: https://pubmed.ncbi.nlm.nih.gov/36856113/
Chronic pain and premature mortality in men and women, using data from UK Biobank. Reply.
Source: J Clin Invest 2023 Mar 01; 133(5). doi: 10.1172/JCI168070Authors: Parisien M, Grant AV, Muralidharan A, Diatchenko L, Mogil JS Pubmed ID: https://pubmed.ncbi.nlm.nih.gov/36856114/
Morphine-induced mechanical hypersensitivity in mice requires δ receptors, β-arrestin2 and c-Src activity.
Source: J Physiol 2023 Mar 01; . doi: 10.1113/JP284003Authors: Singleton S, Hales TG Morphine diminishes pain, but its long-term use is compromised by tolerance and hyperalgesia. Studies implicate δ receptors, β-arrestin2 and Src kinase in tolerance. We examined whether these proteins are also involved in…
Olfactory training reduces pain sensitivity in children and adolescents with primary headaches.
Source: Front Pain Res (Lausanne) 2023; 4. doi: 10.3389/fpain.2023.1091984Authors: Gossrau G, Zaranek L, Klimova A, Sabatowski R, Koch T, Richter M, Haehner A Headache prevalence among children and adolescents has increased over the last few years. Evidence-based treatment options for pediatric headaches remain limited. Research…
Editorial: Surgical techniques for the management of pain.
Source: Front Pain Res (Lausanne) 2023; 4. doi: 10.3389/fpain.2023.1120174Authors: Allam AK, Viswanathan A, Schwalb JM, Patil PG, Larkin MB Pubmed ID: https://pubmed.ncbi.nlm.nih.gov/36860332/
Exploring women’s experiences with persistent pain and pain management following breast cancer treatment: A qualitative study.
Source: Front Pain Res (Lausanne) 2023; 4. doi: 10.3389/fpain.2023.1095377Authors: Smith MD, Manning J, Nielsen M, Hayes SC, Plinsinga ML, Coppieters MW This qualitative study aimed to explore experiences of women with persistent pain following breast cancer treatment, including their perceptions about the cause of their…
Investigation of Pain Sensitivity Following 3 Nights of Disrupted Sleep in Healthy Individuals.
Source: Eur J Pain 2023 Mar 02; . doi: 10.1002/ejp.2101Authors: Hertel E, McPhee ME, Petersen KK Poor quality sleep is a common complaint among people with chronic pain. The co-occurrence of poor sleep quality and chronic pain often comes with increased pain intensity, more disability,…
Low-Dose Δ9-THC Produces Antinociception in Female, But Not Male Rats.
Source: Cannabis Cannabinoid Res 2023 Mar 01; . doi: 10.1089/can.2022.0256Authors: Morgan MM, Stickney JD, Wilson-Poe AR The analgesic effects of delta-9-tetrahydrocannabinol (THC), the primary psychoactive compound in cannabis, have been widely promoted. Unfortunately, animal research is limited by the use of high doses and pain-evoked…
Serum Metabolome Analysis identified amino-acid metabolism associated with pain in people with symptomatic knee Osteoarthritis – a cross-sectional study.
Source: J Pain 2023 Feb 28; . doi: 10.1016/j.jpain.2023.02.023Authors: Mehta O, Vijay A, Gohir SA, Kelly T, Zhang W, Doherty M, Walsh DA, Aithal G, Valdes AM Osteoarthritis (OA) is the most common arthritis affecting synovial joints such as knees and hips of millions of…
Effective quality control in the medical literature: investigation and retraction vs inaction.
Source: J Clin Epidemiol 2023 Feb 28; . doi: 10.1016/j.jclinepi.2023.02.022Authors: Williams ACC, Hearn L, Moore RA, Stewart G, Fisher E, Eccleston C, O’Connell NE Pubmed ID: https://pubmed.ncbi.nlm.nih.gov/36863688/
Low-dose celecoxib-loaded PCL fibers reverse intervertebral disc degeneration by up-regulating CHSY3 expression.
Source: J Nanobiotechnology 2023 Mar 03; 21(1). doi: 10.1186/s12951-023-01823-4Authors: Wang Y, Zheng G, Xie X, Yu W, Wang J, Zang F, Yang C, Xiao Q, Zhang R, Wei L, Wu X, Liang L, Cao P, Xu C, Li J, Hu B, Zhang T, Wu J,…
Clinical evaluation of super-responders vs. non-responders to CGRP(-receptor) monoclonal antibodies: a real-world experience.
Source: J Headache Pain 2023 Feb 27; 24(1). doi: 10.1186/s10194-023-01552-xAuthors: Raffaelli B, Fitzek M, Overeem LH, Storch E, Terhart M, Reuter U Clinical trials and real-world studies revealed a spectrum of response to CGRP(-receptor) monoclonal antibodies (mAbs) in migraine prophylaxis, ranging from no effect at…
Identification of the molecular determinants of antagonist potency in the allosteric binding pocket of human P2X4.
Source: Front Pharmacol 2023; 14. doi: 10.3389/fphar.2023.1101023Authors: Pasqualetto G, Zuanon M, Brancale A, Young MT P2X receptors are a family of ATP-gated cation channels comprising seven subtypes in mammals, which play key roles in nerve transmission, pain sensation and inflammation. The P2X4 receptor in particular…
Design, Synthesis, and Biological Evaluation of the First Radio-Metalated Neurotensin Analogue Targeting Neurotensin Receptor 2.
Source: ACS Omega 2023 Feb 21; 8(7). doi: 10.1021/acsomega.2c07814Authors: Bodin S, Previti S, Jestin E, Vimont D, Ait-Arsa I, Lamare F, Rémond E, Hindié E, Cavelier F, Morgat C Neurotensin receptor 2 (NTS) is a well-known mediator of central opioid-independent analgesia. Seminal studies have highlighted…