February 22-28, 2025
Showing 1-25 of 167.
Ronald Dubner: pioneer in pain research, founding member of the International Association for the Study of Pain, and Former Editor-in-Chief of PAIN.
Source: Pain 2025 Feb 25;. doi: 10.1097/j.pain.0000000000003548 Authors: Sessle BJ Ronald Dubner (1934-2023) was a “giant” in the field of pain. His more than 5 decades of research programs at the US National Institutes of Health and the University of Maryland resulted in important discoveries…
Intra-somatosensory cortical circuits mediating pain-induced analgesia.
Source: Nat Commun 2025 Feb 21; 16(1). doi: 10.1038/s41467-025-57050-y Authors: Huang JY, Jin YX, Dong WY, Zhao W, Cheng PK, Miao JH, Liu A, Wang D, Li J, Zhang Z, Tao W, Zhu X Pain in one part of the body profoundly diminishes the sensation…
Analgesic effect of simultaneously targeting multiple pain processing brain circuits in an aged humanized mouse model of chronic pain by transcranial focused ultrasound.
Source: APL Bioeng 2025 Mar; 9(1). doi: 10.1063/5.0236108Authors: Kim MG, Yeh CY, Yu K, Li Z, Gupta K, He B Low-intensity transcranial focused ultrasound (tFUS) has recently been shown to noninvasively and non-pharmacologically modulate pain hypersensitivity with high spatial specificity and deep brain penetration. However,…
Addressing Pain and Heavy Drinking among Patients in HIV-Care: A Pilot Study of an Integrated Telehealth Intervention.
Source: AIDS Behav 2025 Feb 25; . doi: 10.1007/s10461-025-04660-8Authors: Palfai TP, Kratzer MPL, Taylor JL, Otis JD, Winter MR Chronic pain is common among people living with HIV (PLWH) who engage in heavy drinking and both pain and heavy drinking influence quality of life, functioning,…
Red nucleus mGluR4 and mGluR8 inhibit nociception and the development of neuropathic pain by restraining the expressions of TNF-α and IL-1β.
Source: Neuropharmacology 2025 Feb 24; . doi: 10.1016/j.neuropharm.2025.110387Authors: Xu YL, Xia YT, Zhang MM, Li YJ, Tao XX, Li K, Yang QQ, Tian X, Wu JB, Shi YT, Wang JY, Zeng XY Metabotropic glutamate receptors (mGluR) participate in pain modulation and mediate different effects in…
Equity Using Interventions for Pain and Depression (EQUIPD): A Pilot Randomized Trial.
Source: J Pain 2025 Feb 24; . doi: 10.1016/j.jpain.2025.105353Authors: Matthias MS, Burgess DJ, Daggy JK, Donnelly CE, Flores P, Fowler NR, Garabrant J, Henry N, Henry SG, Huffman M, Kavuri PJ, Ofner S, Perry C, Rand KL, Robles M, Salyers MP, Taylor SL, Hirsh AT…
Suzetrigine: The first Nav1.8 inhibitor approved for the treatment of moderate to severe acute pain.
Source: Drug Discov Ther 2025 Feb 27; . doi: 10.5582/ddt.2025.01010Authors: Hu S, Lyu D, Gao J Opioids are commonly prescribed for the management of moderate to severe pain, but their use is associated with dependency and other adverse effects. For decades, the development of safe…
Dorsal raphe GABA-ergic neurons regulate the susceptibility to social transfer of pain in mice.
Source: Acta Pharmacol Sin 2025 Feb 26; . doi: 10.1038/s41401-025-01494-xAuthors: Ai L, Han Y, Ge T, Sha S, Zhai XJ, Ji R, Zhou Y, Chen DD, Xie A, Zhang WX, Wu Z, Zhang MR, Yang JX, Hu AK, Cao JL, Song LZ, Zhang HX Some…
Optogenetic cortical spreading depression originating from the primary visual cortex induces migraine-like pain and anxiety behaviors in freely moving C57BL/6 J mice.
Source: J Headache Pain 2025 Feb 26; 26(1). doi: 10.1186/s10194-025-01983-8Authors: Yuan H, Na W, Li B, Miao S, Tang W, Kang L, Pi C, Yang C, Xie W, Wang T, Zhai D, Zhao D, Liu R, Yu S Migraine is the second disabling neurological disorder…
Network meta-analysis comparing efficacy of different strategies on medication-overuse headache.
Source: J Headache Pain 2025 Feb 26; 26(1). doi: 10.1186/s10194-025-01982-9Authors: Koonalintip P, Yamutai S, Setthawatcharawanich S, Thongseiratch T, Chichareon P, Wakerley BR Medication-overuse headache (MOH) is the most common secondary headache disorder, resulting from or leading to the frequent use of acute headache medications. Despite…
The properties of TREM1 and its emerging role in pain-related diseases.
Source: Mol Brain 2025 Feb 26; 18(1). doi: 10.1186/s13041-025-01187-wAuthors: Fan Z, Sun S, Wang L, Ge Z The TREM1 receptor, a member of the TREMs family, is expressed by myeloid cells and functions as an initiator or enhancer of the inflammatory response, playing a pivotal…
A cross-sectional study exploring relationships between triglyceride glucose index, atherogenic index of plasma, and chronic pain: NHANES 1999-2004.
Source: Lipids Health Dis 2025 Feb 25; 24(1). doi: 10.1186/s12944-025-02496-8Authors: Yan Z, Zhang H, Liu S, Cui J, Zhu Y, Zhao G, Liu R, Cui R Triglyceride glucose (TyG) index and atherogenic index of plasma (AIP) are indicators of insulin resistance. However, inadequate evidence indicates…
A Genetic and Environmental Analysis of Inflammatory Factors in Chronic Widespread Pain Using the TwinsUK Cohort.
Source: Biomolecules 2025 Jan 21; 15(2). doi: 10.3390/biom15020155Authors: Cherny SS, Livshits G, Williams FMK Chronic widespread musculoskeletal pain (CWP), a significant health issue affecting individuals and society, is often diagnosed as part of fibromyalgia but is not generally considered inflammatory. This study investigated the relationship…
Preclinical Insights into the Role of Kir4.1 in Chronic Pain and Depression: Mechanisms and Therapeutic Potential.
Source: Biomolecules 2025 Jan 23; 15(2). doi: 10.3390/biom15020165Authors: Zha T, Fang X, Wan J, Chen X, Lin J, Chen Q Chronic pain and mental health disorders, such as depression and anxiety, frequently co-occur and share underlying mechanisms involving neuronal excitability and synaptic transmission. The inwardly…
Chikungunya Particle and RNA Induce Mechanical and Heat Hypersensitivities in a TRPV1-Dependent Manner.
Source: Biomolecules 2025 Jan 23; 15(2). doi: 10.3390/biom15020171Authors: da Silva LCM, Dos Santos Maia AC, de Sousa NCF, Pavi CP, Savi BP, Nagashima S, Damasceno S, Schneider AH, Mascarin LZ, Rodrigues JFS, Monteiro CRAV, Silva IT, Fongaro G, Monteiro-Neto V, Bomfim MRQ, Cunha TM, de…
Brain Mechanisms of Hypnosis.
Source: Brain Sci 2025 Jan 31; 15(2). doi: 10.3390/brainsci15020142Authors: De Benedittis G Hypnosis is the longest-lasting of all psychotherapies and one of the oldest practiced methods for the control of pain and other stress-related chronic disorders […]. Pubmed ID: https://pubmed.ncbi.nlm.nih.gov/40002475/
Exploratory study on the ascending pain pathway in patients with chronic neck and shoulder pain based on combined brain and spinal cord diffusion tensor imaging.
Source: Front Neurosci 2025; 19. doi: 10.3389/fnins.2025.1460881Authors: Qiu Z, Liu T, Zeng C, Yang M, Yang H, Xu X To explore the changes in the white matter microstructure of the ascending pain conduction pathways in patients with chronic neck and shoulder pain (CNSP) using combined…
Mechanism of Intervertebral Disc Degeneration via the β-Catenin/CCL2 Pathway in Sox9 Conditional Knockout Mice.
Source: JOR Spine 2025 Mar; 8(1). doi: 10.1002/jsp2.70053Authors: Aboushaala K, Chee A, Ko F, Alkhudari J, Sumughan S, An HS, Samartzis D, Oh CD Degenerative changes in the intervertebral disc (IVD) are known to be a main cause of low back pain (LBP), oftentimes necessitating…
‘I want to know that it’s worth me attending’: A qualitative analysis of consumers’ decisions not to attend their chronic pain group education session.
Source: Br J Pain 2025 Feb 24; . doi: 10.1177/20494637251322977Authors: Searle AK, Wall CL, Tan C, Herriot P Many pain clinics encourage/mandate attendance at introductory group pain education sessions. Despite high non-attendance rates, no studies have examined consumer-reported reasons for non-attendance. The aim of this…
Prediction and validation of anoikis-related genes in neuropathic pain using machine learning.
Source: PLoS One 2025; 20(2). doi: 10.1371/journal.pone.0314773Authors: He Y, Wei Y, Wang Y, Ling C, Qi X, Geng S, Meng Y, Deng H, Zhang Q, Qin X, Chen G Neuropathic pain (NP) can be induced by a variety of clinical conditions, such as spinal cord…
The effect of peer group management intervention on chronic pain intensity, number of areas of pain, and pain self-efficacy.
Source: Scand J Pain 2025 Jan 01; 25(1). doi: 10.1515/sjpain-2024-0018Authors: Reilimo MI, Sainio M, Liira J, Laurola M Chronic pain causes loss of workability, and pharmacological treatment is often not sufficient, whereas psychosocial treatments may relieve continual pain. This study aimed to investigate the effect…
Cost Trends of New-To-Market Neurologic Medications: An Insurance Claims Database Analysis.
Source: Neurology 2025 Mar 25; 104(6). doi: 10.1212/WNL.0000000000213428Authors: Gusovsky Chevalier AV, Lin CC, Kerber K, Reynolds EL, Callaghan BC, Burke JF Costs for neurologic medications have increased considerably in recent years. Since 2014, more than 30 neurologic medications have been approved by the US Food…
Prdx5 regulates macrophage polarization by modulating the TLR4/NF-κB pathway to promote apoptosis in chronic prostatitis.
Source: Int Immunopharmacol 2025 Feb 26; 151. doi: 10.1016/j.intimp.2025.114332Authors: Wu W, Meng T, Wang Y, Chen J, Liang C Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a prevalent urological disorder characterized by urinary symptoms, pelvic pain, and sexual dysfunction. Despite its high prevalence, the pathogenesis…
Deciphering the Role of Circulating miRNAs in the Etiology and Pathophysiology of Endometriosis: An Updated Compiled Review.
Source: Exp Cell Res 2025 Feb 25; . doi: 10.1016/j.yexcr.2025.114482Authors: Pant A, Moar K, Arora TK, Dakal TC, Ranga V, Sharma NK, Maurya PK Endometriosis is characterized by the presence of endometrial tissue outside of the uterus. It is a benign chronic condition with incapacitating…
OMEGA-3-ENRICHED FISH OIL REDUCES THE CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHY IN MICE.
Source: Neuropharmacology 2025 Feb 25; . doi: 10.1016/j.neuropharm.2025.110384Authors: Melato J, Goldoni FC, Benvenutti L, Corrêa TP, Remor AP, Varela KG, Stoeberl LC, Fernandes GG, de Lima Rasga G, Passos GF, Apel MA, Klein-Junior LC, Santin JR, da Costa R, Meira Quintão NL Cancer is a…