February 15-21, 2025
Showing 1-25 of 149.
GPR37L1 identifies spinal cord astrocytes and protects neuropathic pain after nerve injury.
Source: Neuron 2025 Feb 11;. doi: 10.1016/j.neuron.2025.01.012 Authors: Xu J, Yan Z, Bang S, Velmeshev D, Ji RR Astrocytes in the spinal cord dorsal horn (SDH) play a pivotal role in synaptic transmission and neuropathic pain. However, the precise classification of SDH astrocytes in health…
Buprenorphine, Pain, and Opioid Use in Patients Taking High-Dose Long-Term Opioids: A Randomized Clinical Trial.
Source: JAMA Intern Med 2025 Feb 17; . doi: 10.1001/jamainternmed.2024.8361Authors: Becker WC, Seal KH, Nelson DB, DeRonne BM, Kats AM, Morasco BJ, Frank JW, Makris UE, Painter JT, Allen KD, Mixon AS, Bohnert A, Reznik TE, Hagedorn HJ, Hammett P, Borsari B, Baxley C, Krebs…
Infusion of young donor plasma components in older patients modifies the immune and inflammatory response to surgical tissue injury: a randomized clinical trial.
Source: J Transl Med 2025 Feb 14; 23(1). doi: 10.1186/s12967-025-06215-wAuthors: Gaudilliere B, Xue L, Tsai AS, Gao X, McAllister TN, Tingle M, Porras G, Feinstein I, Feyaerts D, Verdonk F, Sabayev M, Hedou J, Ganio EA, Berson E, Becker M, Espinosa C, Kim Y, Lehallier…
Efficacy of a physical rehabilitation program using virtual reality in patients with chronic tendinopathy: A randomized controlled trial protocol (VirTendon-Rehab).
Source: Digit Health 2025; 11. doi: 10.1177/20552076241297043Authors: Lucena-Anton D, Dominguez-Romero JG, Chacon-Barba JC, Santi-Cano MJ, Luque-Moreno C, Moral-Munoz JA To analyze the efficacy of a virtual reality (VR)-based rehabilitation program in people with chronic tendinopathy (CT) on pain, muscle activation pattern, range of motion, muscle…
Integrated bioinformatics analysis of the effects of chronic pain on patients with spinal cord injury.
Source: Front Cell Neurosci 2025; 19. doi: 10.3389/fncel.2025.1457740Authors: Zhang J, Qi L, Sun Y, Chen S, Liu J, Chen J, Yan F, Wang W, Wang Q, Chen L Spinal cord injury (SCI) poses a substantial challenge in contemporary medicine, significantly impacting patients and society. Emerging…
Alcohol Consumption Modulates the Development of Chronic Pain in COVID-19 Patients: A Network Meta-Analysis.
Source: ACS Pharmacol Transl Sci 2025 Feb 14; 8(2). doi: 10.1021/acsptsci.4c00479Authors: Bishir M, Vigorito M, Chan MH, Khan MAS, Chang SL The mechanisms underlying the onset and progression of chronic pain in COVID-19 patients have been understudied. Using network meta-analysis, we previously demonstrated that alcohol…
Towards painless and productive research relationships: reflections on study design by a researcher with chronic pain for participants with chronic pain.
Source: Front Pain Res (Lausanne) 2024; 5. doi: 10.3389/fpain.2024.1450667Authors: Wilkinson C Building flexibility into the research design of a study allows for responsiveness to the embodied and fluctuating nature of participants’ chronic illnesses, which may be shaped, for instance, by flare-ups and periods of remission…
Comparisons of the effects of psychologically-informed and usual physiotherapy on pain sensitivity in chronic low back pain: an exploratory randomized controlled trial.
Source: Arch Physiother 2025; 15. doi: 10.33393/aop.2025.3323Authors: Massé-Alarie H, Desgagnés A, Côté-Picard C, Liberty O, Langevin P, Piché M, Tousignant-Laflamme Y The presence of altered central pain processing and modulation, as well as negative psychological factors, have been suggested to impede recovery in chronic low…
Molecular Basis of PAC1R Allosteric Modulation with Lipids in Membranes.
Source: bioRxiv 2025 Jan 28; . doi: 10.1101/2025.01.27.635027Authors: Hamilton NB, Yang B, Xiang C, Li T, Schneebeli ST, Li J The pituitary adenylate cyclase-activating polypeptide receptor I (PAC1R) represents a highly sought-after therapeutic target for chronic pain, migraine, and post-traumatic stress. As a class B…
De novo expression of neuropeptide Y in sensory neurons does not contribute to peripheral neuropathic pain.
Source: bioRxiv 2025 Jan 27; . doi: 10.1101/2025.01.25.634591Authors: Cooper AH, Nie A, Hedden NS, Herzog H, Taylor BK Nerve damage induces a robust expression of the pain-modulatory peptide neuropeptide Y (NPY) in large-diameter primary afferent neurons that innervate the dorsal horn of the spinal cord…
Cortical astrocyte activation triggers meningeal nociception and migraine-like pain.
Source: bioRxiv 2025 Feb 18; . doi: 10.1101/2025.02.08.637109Authors: Bree D, Zhao J, Stratton J, Levy D Migraine attacks are believed to originate in the brain, but the exact mechanisms by which the brain generates peripheral nociceptive signals that drive migraine pain remain unclear. Sensory cortex…
Metabolic reprogramming in the spinal cord drives the transition to pain chronicity.
Source: bioRxiv 2025 Feb 01; . doi: 10.1101/2025.01.30.635746Authors: Tagne AM, Fotio Y, Lee HL, Jung KM, Katz J, Ahmed F, Le J, Bazinet R, Jang C, Piomelli D Acute injuries can progress into painful states that endure long after healing. The mechanism underlying this transition…
TRPV1+ neurons promote cutaneous immunity against Schistosoma mansoni.
Source: bioRxiv 2025 Feb 08; . doi: 10.1101/2025.02.06.636930Authors: Inclan-Rico JM, Stephenson A, Napuri CM, Rossi HL, Hung LY, Pastore CF, Luo W, Herbert DR Immunity against skin-invasive pathogens requires mechanisms that rapidly detect, repel or immobilize the infectious agent. While bacteria often cause painful cutaneous…
Targeted ubiquitination of Na 1.8 reduces sensory neuronal excitability.
Source: bioRxiv 2025 Feb 04; . doi: 10.1101/2025.02.04.636451Authors: Tyagi S, Ghovanloo MR, Alsaloum M, Effraim P, Higerd-Rusli GP, Dib-Hajj F, Zhao P, Liu S, Waxman SG, Dib-Hajj SD Chronic pain and addiction are a significant global health challenge. Voltage-gated sodium channel Na 1.8, a pivotal…
Chronic intermittent ethanol produces nociception through endocannabinoid-independent mechanisms in mice.
Source: bioRxiv 2025 Feb 04; . doi: 10.1101/2024.11.08.622656Authors: Miliano C, Dong Y, Proffit M, Corvalan N, Natividad LA, Gregus AM, Buczynski MW Alcohol use disorder (AUD) affects millions of people and represents a significant health and economic burden. Pain represents a frequently under-treated aspect of…
Tumor necrosis factor (TNF) inhibitors for juvenile idiopathic arthritis.
Source: Cochrane Database Syst Rev 2025 Feb 20; 2. doi: 10.1002/14651858.CD013715.pub2Authors: Cagnotto G, Juhl CB, Ahlström F, Wikström F, Bruschettini M, Petersson I, Dreyer L, Compagno M Juvenile idiopathic arthritis (JIA) is a rheumatic disorder that causes chronic joint inflammation beginning before the age of…
Comparing Maintenance Therapy Achievement for Opioid-Experienced Patients Converted to Buprenorphine for Chronic Pain Management.
Source: J Pain Palliat Care Pharmacother 2025 Feb 20; . doi: 10.1080/15360288.2025.2464686Authors: Sams C, Cheng S Treatment of chronic, non-cancer pain can be challenging in the presence of long-term opioid therapy (LTOT). Buprenorphine products can provide a unique option for chronic pain treatment due to…
Diroximel fumarate acts through Nrf2 to attenuate methylglyoxal-induced nociception in mice and decrease ISR activation in DRG neurons.
Source: Diabetes 2025 Feb 20; . doi: 10.2337/db23-1025Authors: Yousuf MS, Moreno MM, Woodall BJ, Thakur V, Li J, He L, Arjarapu R, Royer D, Zhang J, Chattopadhyay M, Grace PM, Price TJ Diabetic neuropathic pain is associated with elevated plasma levels of methylglyoxal (MGO). MGO…
Psychological Support for Chronic Low Back Pain: A Systematic Review on the Validity of a Growing Remote Approach.
Source: Curr Pain Headache Rep 2025 Feb 20; 29(1). doi: 10.1007/s11916-024-01340-5Authors: Anselmo A, Pagano M, Cappadona I, Cardile D, Calabrò RS, Corallo F Low back pain (LBP) is one of the main health problems imposing a significant burden both personally and socially. It is estimated…
The angiotensin II type 2 receptor antagonists, PD123,319 ((S-( +)-1-[(4-(dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid), EMA300 (5-(2,2-diphenylacetyl)-4-[(4-methoxy-3-methylphenyl)methyl]-1,4,6,7-tetrahydroimidazo[4,5-c]pyridine-6-carboxylic acid) and EMA401 ((3S)-5-(benzyloxy)-2-(2,2-diphenylacetyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid), evoke pain relief in a varicella zoster virus-induced rat model of neuropathic pain.
Source: Inflammopharmacology 2025 Feb 20; . doi: 10.1007/s10787-025-01650-zAuthors: Das V, Lam AL, Smith MT Post-herpetic neuralgia (PHN) is a type of neuropathic (nerve) pain that persists for more than 3 months after crusting of the last shingles lesion. It is difficult to relieve with analgesic/adjuvant medications,…
Sodium hyaluronate and acupotomy bone decompression alleviates inflammatory responses in patients with knee osteoarthritis.
Source: Inflammopharmacology 2025 Feb 20; . doi: 10.1007/s10787-025-01667-4Authors: Wu J, Tang Q, Tan X Knee osteoarthritis (KOA), predominantly affecting middle-aged and elderly populations, induces localized joint pain and functional impairment. It was to evaluate the effectiveness of acupotomy bone decompression (ABD) combined with sodium hyaluronate…
Immune cells mediated the causal relationship between perturbational phenotyping of human blood cells and neuropathy pain: a two-sample and mediated mendelian randomized study.
Source: Cell Mol Biol (Noisy-le-grand) 2025 Feb 20; 71(2). doi: 10.14715/cmb/2025.71.2.17Authors: Chen Q, Zhong T, Liu J, Cai D, Gao H, Chen M Current research reveals a complex relationship between blood cells(BC) and neuropathic pain(NP), though the underlying biological mechanisms remain unclear. This study applies…
New Persistent Opioid Use After Surgery.
Source: JAMA Netw Open 2025 Feb 03; 8(2). doi: 10.1001/jamanetworkopen.2024.60794Authors: Bologheanu R, Bilir A, Kapral L, Gruber F, Kimberger O New persistent opioid use after surgery is contributing to the opioid crisis affecting the US, and interventions to limit postoperative opioid prescriptions have been proposed…
Comprehensive Analysis of Migraine Burden and Treatment Trends: A Retrospective Cohort Study of Recent Large Multiple Commercial Payer Databases. (P9-12.005).
Source: Neurology 2024 Apr 09; 102(7_supplement_1). doi: 10.1212/WNL.0000000000208156Authors: Petrova M, Besedina O, Hare B, Gupta A, Lakhan S Migraine affects about 14.4% of the population causing substantial burden. Our objective was to describe the populations of individuals diagnosed with migraine headache with regards to diagnosis…
Spinal cord stimulation (SCS) induced favorable neuromodulative outcome in the treatment of chronic neuropathic pain syndrome in children.
Source: Eur J Paediatr Neurol 2025 Feb 15; 54. doi: 10.1016/j.ejpn.2025.02.007Authors: Barišić N, Nemir J, Perković R, Frančić M, Lombardi R Chronic pharmaco-resistant pain syndrome (CPS) requires different therapeutic approaches based on the underlying pathology. Spinal cord stimulation (SCS) in children with chronic neuropathic pain…