December 2-8, 2023
Showing 1-25 of 71.
Intervertebral disc human nucleus pulposus cells associated with back pain trigger neurite outgrowth in vitro and pain behaviors in rats.
Source: Sci Transl Med 2023 Dec 06; 15(725). doi: 10.1126/scitranslmed.adg7020 Authors: Jiang W, Glaeser JD, Kaneda G, Sheyn J, Wechsler JT, Stephan S, Salehi K, Chan JL, Tawackoli W, Avalos P, Johnson C, Castaneda C, Kanim LEA, Tanasansomboon T, Burda JE, Shelest O, Yameen H,…
Docking for EP4R antagonists active against inflammatory pain.
Source: Nat Commun 2023 Dec 06; 14(1). doi: 10.1038/s41467-023-43506-6 Authors: Gahbauer S, DeLeon C, Braz JM, Craik V, Kang HJ, Wan X, Huang XP, Billesbølle CB, Liu Y, Che T, Deshpande I, Jewell M, Fink EA, Kondratov IS, Moroz YS, Irwin JJ, Basbaum AI, Roth…
Single-cell RNA sequencing uncovers the cell type-dependent transcriptomic changes in the retrosplenial cortex after peripheral nerve injury.
Source: Cell Rep 2023 Dec 03; 42(12). doi: 10.1016/j.celrep.2023.113551 Authors: Wang JH, Wu C, Lian YN, Cao XW, Wang ZY, Dong JJ, Wu Q, Liu L, Sun L, Chen W, Chen WJ, Zhang Z, Zhuo M, Li XY The retrosplenial cortex (RSC) is a vital…
Crosstalk between GABA receptors in astrocytes and neurons triggered by general anesthetic drugs.
Source: Transl Res 2023 Nov 30;. doi: 10.1016/j.trsl.2023.11.007 Authors: Wang DS, Ju L, Pinguelo AG, Kaneshwaran K, Haffey SC, Lecker I, Gohil H, Wheeler MB, Kaustov L, Ariza A, Yu M, Volchuk A, Steinberg BE, Goldenberg NM, Orser BA General anesthetic drugs cause cognitive deficits…
Transcranial Direct Current Stimulation Attenuates the Chronic Pain of Osteoarthritis in Rats via Reducing NMDAR2B Expressions in the Spinal Cord.
Source: J Musculoskelet Neuronal Interact 2023 Dec 01; 23(4). Authors: Liu Z, Chen X, Chen P, Wang L Osteoarthritis (OA) has been the common cause to lead to chronic pain. Transcranial direct current stimulation (tDCS) is effective in the treatment of chronic pain, but its…
Intravenous recombinant cerebellin 1 treatment restores spinal glutamate delta 1 receptor signaling and mitigates chronic pain.
Source: Br J Pharmacol 2023 Dec 03; . doi: 10.1111/bph.16296Authors: Sabnis SS, S Narasimhan KK, Chettiar PB, Gakare SG, Shelkar GP, Asati DG, Thakur SS, Dravid SM Chronic pain remains a major clinical problem and there is a critical need to develop effective therapeutics. We…
A causative role for periarticular skeletal muscle weakness in the progression of joint damage and pain in OA.
Source: Sci Rep 2023 Dec 04; 13(1). doi: 10.1038/s41598-023-46599-7Authors: Kim JR, Pham THN, Kim WU, Kim HA Although osteoarthritis (OA) is regarded as a disease of the articular cartilage, recent research has demonstrated alterations in periarticular muscles that surround the affected joint. Here, we investigated…
USP5: Comprehensive insights into structure, function, biological and disease-related implications, and emerging therapeutic opportunities.
Source: Mol Cell Probes 2023 Dec 02; . doi: 10.1016/j.mcp.2023.101944Authors: Si-Ting G, Xin X, Wang ZY, Hu YY, Feng Q Ubiquitin specific protease 5 (USP5) is a vital deubiquitinating enzyme that regulates various physiological functions by removing ubiquitin chains from target proteins. This review provides…
Antinociceptive action of cannabidiol on thermal sensitivity and post-operative pain in male and female rats.
Source: Behav Brain Res 2023 Dec 02; . doi: 10.1016/j.bbr.2023.114793Authors: Arantes ALF, Carvalho MC, Brandão ML, do Prado WA, Souza Crippa JA, Lovick TA, Genaro K This study investigated the antinociceptive potential of cannabidiol (CBD) in male and female Wistar rats. The assessment and analysis…
Dual-neuromodulation strategy in pain management of herpes zoster ophthalmicus: retrospective cohort study and literature review.
Source: Ann Med 2023; 55(2). doi: 10.1080/07853890.2023.2288826Authors: Ma J, Wan Y, Yang L, Huang D, Zhou H Effective pain control of herpes zoster ophthalmicus (HZO) is not only essential to attenuate the clinical symptoms but to reduce the risk of postherpetic neuralgia development. Recently, neuromodulation…
Ethical Challenges of Virtual Reality Technology Interventions for the Vulnerabilities of Patients With Chronic Pain: Exploration of Technician Responsibility.
Source: J Med Internet Res 2023 Dec 04; 25. doi: 10.2196/49237Authors: Zhou S, Gromala D, Wang L Chronic pain, a common disease, is a crucial global public health concern. Approximately 20% of the worldwide population is affected by chronic pain, which accounts for 15% to…
The optimal dose of pain neuroscience education added to an exercise programme for patients with chronic spinal pain: A systematic review and dose-response meta-analysis.
Source: Pain 2023 Nov 30; . doi: 10.1097/j.pain.0000000000003126Authors: Núñez-Cortés R, Salazar-Méndez J, Calatayud J, Malfliet A, Lluch E, Mendez-Rebolledo G, Guzmán-Muñoz E, López-Bueno R, Suso-Martí L Pain neuroscience education (PNE) has shown promising results in the management of patients with chronic spinal pain (CSP). However,…
Remifentanil-induced hyperalgesia in healthy volunteers: a systematic review and meta-analysis of randomized controlled trials.
Source: Pain 2023 Nov 30; . doi: 10.1097/j.pain.0000000000003119Authors: Dello Russo C, Di Franco V, Tabolacci E, Cappoli N, Navarra P, Sollazzi L, Rapido F, Aceto P Recent literature suggests that the withdrawal of remifentanil (RF) infusion can be associated with hyperalgesia in clinical and nonclinical…
NLRP3 inflammasome activation in sensory neurons promotes chronic inflammatory and osteoarthritis pain.
Source: Immunother Adv 2023; 3(1). doi: 10.1093/immadv/ltad022Authors: Silva Santos Ribeiro P, Willemen HLDM, Versteeg S, Martin Gil C, Eijkelkamp N Pain is one of the most debilitating symptoms in rheumatic diseases. Pain often persists after total knee replacement in osteoarthritis, or when inflammation is minimal/absent…
Periodic Mechanical Stress Inhibits the Development of Osteoarthritis via Regulating ATF3-Akt Axis.
Source: J Inflamm Res 2023; 16. doi: 10.2147/JIR.S419186Authors: Lou Y, Song F, Kang Y, Xu Y The development of osteoarthritis (OA) has been linked to mechanical factors. Studies suggest that periodic mechanical stress (PMS) may be a factor contributing to cartilage repair and the onset…
Mechanistic Evaluation of Antiarthritic Effects of Citronellol in CFA-Induced Arthritic Rats.
Source: ACS Omega 2023 Nov 28; 8(47). doi: 10.1021/acsomega.3c06374Authors: Dar E, Mobashar A, Shabbir A, Mushtaq MN, Anjum I, Z Gaafar AR, Nafidi HA, Bourhia M Rheumatoid arthritis (RA) is an autoimmune disease characterized by systemic inflammation, joint tissue damage, pain, and synovitis. It leads…
The impact of adverse childhood experiences and posttraumatic stress symptoms on chronic pain.
Source: Front Psychol 2023; 14. doi: 10.3389/fpsyg.2023.1243570Authors: Stapleton P, Kang Y, Schwarz R, Freedom J Chronic pain is a prevalent worldwide health condition. The current study aimed to extend previous research that investigated the dynamics between chronic pain, adverse childhood experiences (ACEs), and post-traumatic stress…
Peripheral gating of pain by glial endozepine.
Source: bioRxiv 2023 Nov 21; . doi: 10.1101/2023.11.20.567848Authors: Li X, Prudente AS, Prato V, Guo X, Hao H, Jones F, Figoli S, Mullen P, Wang Y, Tonnello R, Lee SH, Shah S, Maffei B, Berta T, Du X, Gamper N We report that diazepam binding…
Inhibition of TRPM8 function by the prostacyclin receptor requires coupling to Gq/11 proteins.
Source: Br J Pharmacol 2023 Dec 03; . doi: 10.1111/bph.16295Authors: Trif C, Banica AM, Manolache A, Anghel SA, Huţanu DE, Stratulat T, Badea R, Oprita G, Selescu T, Petrescu SM, Sisignano M, Offermanns S, Babes A, Tunaru S The Transient Receptor Potential Melastatin subtype 8…
Remission of hypersensitivity by simple weight load stimuli in a complex regional pain syndrome mouse model.
Source: J Orthop Res 2023 Dec 03; . doi: 10.1002/jor.25750Authors: Kiyomoto K, Emori M, Hanaka M, Teramoto A, Hayakawa H, Takashima K, Yamashita T, Iba K Painful sensitivity of the hand or foot are the most common and debilitating symptoms of complex regional pain syndrome…
Chronic restraint stress and social transfer of stress produce tactile allodynia mediated by the HMGB1/TNF.Ñó./TNFR1 pathway in female and male rats.
Source: Physiol Behav 2023 Nov 30; . doi: 10.1016/j.physbeh.2023.114418Authors: Pluma-Pluma A, García G, Murbartián J Previous studies have shown the relevance of high mobility group box 1 protein (HMGB1) and tumor necrosis factor α (TNFα) in nerve or tissue injury-induced nociception. However, the role of…
Fundamental Neurochemistry Review: The role of enteroendocrine cells in visceral pain.
Source: J Neurochem 2023 Dec 01; . doi: 10.1111/jnc.16022Authors: Londregan A, Alexander TD, Covarrubias M, Waldman SA While visceral pain is commonly associated with disorders of the gut-brain axis, underlying mechanisms are not fully understood. Dorsal root ganglion (DRG) neurons innervate visceral structures and undergo…
Novel Targets and Drug Delivery System in the Treatment of Postoperative Pain: Recent Studies and Clinical Advancement.
Source: Curr Drug Targets 2023 Nov 30; . doi: 10.2174/0113894501271207231127063431Authors: Satapathy T, Singh G, Pandey RK, Shukla SS, Bhardwaj SK, Gidwani B Pain is generated by a small number of peripheral targets. These can be made more sensitive by inflammatory mediators. The number of opioids…
P-selectin-dependent leukocyte adhesion is governed by endolysosomal two-pore channel 2.
Source: Cell Rep 2023 Nov 29; 42(12). doi: 10.1016/j.celrep.2023.113501Authors: Goretzko J, Pauels I, Heitzig N, Thomas K, Kardell M, Naß J, Krogsaeter EK, Schloer S, Spix B, Linard Matos AL, Leser C, Wegner T, Glorius F, Bracher F, Gerke V, Rossaint J, Grimm C, Rescher…
Associations between the use of common nonsteroidal anti-inflammatory drugs, genetic susceptibility and dementia in participants with chronic pain: A prospective study based on 194,758 participants from the UK Biobank.
Source: J Psychiatr Res 2023 Nov 26; 169. doi: 10.1016/j.jpsychires.2023.11.030Authors: Yuan S, Ling Y, Huang X, Tan S, Li W, Xu A, Lyu J To investigate the potential relationship between common nonsteroidal anti-inflammatory drugs (NSAIDs), genetic susceptibility and all-cause dementia (ACD), Alzheimer’s disease (AD), and…