August 3-9, 2024
Showing 1-25 of 109.
Molecular mimicry in multisystem inflammatory syndrome in children.
Source: Nature 2024 Aug 07;. doi: 10.1038/s41586-024-07722-4 Authors: Bodansky A, Mettelman RC, Sabatino JJ, Vazquez SE, Chou J, Novak T, Moffitt KL, Miller HS, Kung AF, Rackaityte E, Zamecnik CR, Rajan JV, Kortbawi H, Mandel-Brehm C, Mitchell A, Wang CY, Saxena A, Zorn K, Yu…
Interleukin-35 alleviates neuropathic pain and induces an anti-inflammatory shift in spinal microglia in nerve-injured male mice.
Source: Brain Behav Immun 2024 Aug 01;. doi: 10.1016/j.bbi.2024.07.043 Authors: Fiore NT, Hayes JP, Williams SI, Moalem-Taylor G Immune cells are critical in promoting neuroinflammation and neuropathic pain and in facilitating pain resolution, depending on their inflammatory and immunoregulatory cytokine response. Interleukin (IL)-35, secreted by…
Mechanisms of sensory adaptation and inhibition of the cold and menthol receptor TRPM8.
Source: Sci Adv 2024 Aug 02; 10(31). doi: 10.1126/sciadv.adp2211 Authors: Yin Y, Park CG, Zhang F, G Fedor J, Feng S, Suo Y, Im W, Lee SY Our sensory adaptation to cold and chemically induced coolness is mediated by the intrinsic property of TRPM8 channels…
H-coil repetitive transcranial magnetic stimulation does not improve executive function in patients with chronic peripheral neuropathic pain: a randomized sham-controlled crossover study.
August 3-9, 2024 | |
Source: Front Psychiatry 2024; 15. doi: 10.3389/fpsyt.2024.1401008Authors: Farnes N, Jacobsen HB, Stubhaug A, Vambheim SM Deep rTMS is an increasingly popular noninvasive brain stimulation technique which has shown promise for treating cognitive impairments. However, few studies have investigated the cognitive effects it could exert in…
In vivo determination of analgesic and anti-inflammatory activities of isolated compounds from Cleome amblyocarpa and molecular modelling for the top active investigated compounds.
August 3-9, 2024 | |
Source: RSC Adv 2024 Aug 05; 14(34). doi: 10.1039/d4ra04496gAuthors: El-Ayouty MM, Eltahawy NA, Abd El-Sameaa AM, Badawy AM, Darwish KM, Elhady SS, Shokr MM, Ahmed SA Barr. and Murb. from the family Cleomaceae is used in folk medicine as it has analgesic, anti-inflammatory, antibacterial and…
Exploring the association between patient-drawn pain diagrams and psychological and physical health variables: A large-scale study of patients with low back pain.
August 3-9, 2024 | |
Source: Eur J Pain 2024 Aug 07; . doi: 10.1002/ejp.4711Authors: Harsted S, Chang NHS, Nim C, Young JJ, McNaughton DT, O’Neill S Despite the use of Patient-Drawn Pain Drawings (PDPDs) in clinical settings, their validity as indicators of psychological distress remains debated. We aimed to…
Correlates of chronic pain onset and recovery in the CoLaus cohort.
August 3-9, 2024 | |
Source: Eur J Pain 2024 Aug 07; . doi: 10.1002/ejp.4712Authors: Dirupo G, Rossel JB, Fournier N, D’Andrea A, Vollenweider P, Decosterd I, Suter MR, Berna C Only few previous cohort studies examined simultaneously predictors of chronic pain (CP) onset and recovery. Furthermore, these studies used…
Identification and validation of aging-related genes in neuropathic pain using bioinformatics.
August 3-9, 2024 | |
Source: Front Genet 2024; 15. doi: 10.3389/fgene.2024.1430275Authors: Gao H, Dong G, Yao Y, Yang H Neuropathic pain (NP) is a debilitating and refractory chronic pain with a higher prevalence especially in elderly patients. Cell senescence considered a key pathogenic factor in NP. The objective of…
Single simple question in axonal polyneuropathy.
August 3-9, 2024 | |
Source: Muscle Nerve 2024 Aug 08; . doi: 10.1002/mus.28209Authors: Bhandari V, Abraham A, Lovblom LE, Bril V The single simple question (SSQ), “What percentage of normal (0%-100%) do you feel regarding your disease?” has proven feasible and valid in assessing myasthenia gravis and a heterogeneous…
Validation of HAND OA US inflammatory and structural damage score (HOUSE) for thumb base joints: Systematic review on truth & discrimination.
August 3-9, 2024 | |
Source: Rheumatology (Oxford) 2024 Aug 08; . doi: 10.1093/rheumatology/keae417Authors: Kortekaas MC, Vanhaverbeke T, Keen HI, Terslev L, Hammer HB, D’Agostino MA, Wittoek R Recently, the HAND osteoarthritis (OA) ULTRASOUND (US) Examination (HOUSE) inflammatory and structural damage scores were developed by the OMERACT US working group….
Exploring viral neuropathic pain: Molecular mechanisms and therapeutic implications.
August 3-9, 2024 | |
Source: PLoS Pathog 2024 Aug; 20(8). doi: 10.1371/journal.ppat.1012397Authors: Xu S, Li H, Ai Z, Guo R, Cheng H, Wang Y As the Coronavirus Disease 2019 (COVID-19) pandemic continues, there is a growing concern regarding the relationship between viral infections and neuropathic pain. Chronic neuropathic pain…
The effect of acute social isolation on neural molecular responses in components of the social decision-making network.
August 3-9, 2024 | |
Source: BMC Genomics 2024 Aug 08; 25(1). doi: 10.1186/s12864-024-10653-zAuthors: Lopes PC, Chang M, Holloway F, Fatusin B, Patel S, Siemonsma C, Kindel M Prolonged or chronic social isolation has pronounced effects on animals, ranging from altered stress responses, increased anxiety and aggressive behaviour, and even…
Quercetin enhances decidualization through AKT-ERK-p53 signaling and supports a role for senescence in endometriosis.
August 3-9, 2024 | |
Source: Reprod Biol Endocrinol 2024 Aug 08; 22(1). doi: 10.1186/s12958-024-01265-zAuthors: Delenko J, Xue X, Chatterjee PK, Hyman N, Shih AJ, Adelson RP, Safaric Tepes P, Gregersen PK, Metz CN Patients with endometriosis suffer with chronic pelvic pain and infertility, and from the lack of pharmacologic…
Exploring the Analgesic Initiation Mechanism of Tuina in the Dorsal Root Ganglion of Minor CCI Rats via the TRPV1/TRPA1-cGMP Pathway.
August 3-9, 2024 | |
Source: Pain Res Manag 2024; 2024. doi: 10.1155/2024/2437396Authors: Yang Z, Sa C, Yu T, Chen J, Zhang R, Zhang Y, Liu J, Zhang H, Sun J Tuina is a treatment method in traditional Chinese medicine which has analgesic effects and effectively alleviates the symptoms of…
CCL18 promotes endometriosis by increasing endometrial cell migration and neuroangiogenesis.
August 3-9, 2024 | |
Source: Eur J Histochem 2024 Aug 06; 68(3). doi: 10.4081/ejh.2024.4052Authors: Peng Y, Ding S, Xu P, Zhang X, Wang J, Li T, Liao L, Zhang X Endometriosis is an estrogen-dependent inflammatory gynecological disease whose pathogenesis is unclear. C-C motif chemokine ligand 18 (CCL18), a chemokine,…
Identifying the genetic association between the cerebral cortex and fibromyalgia.
August 3-9, 2024 | |
Source: Cereb Cortex 2024 Aug 01; 34(8). doi: 10.1093/cercor/bhae318Authors: Liu A, Wang J, Jin T, Jiang Z, Huang S, Li S, Ying Z, Jiang H Fibromyalgia (FM) is a central sensitization syndrome that is strongly associated with the cerebral cortex. This study used bidirectional two-sample…
Co-producing research study recruitment strategies with and for children and young people for paediatric chronic pain studies.
August 3-9, 2024 | |
Source: Front Pain Res (Lausanne) 2024; 5. doi: 10.3389/fpain.2024.1358509Authors: Ghio D, Lunt LE, Bridges A, Gahr L, Hood AM Children and young people experiencing chronic pain are at greater risk of inequitable and poor-quality pain management, which has implications for future management of pain in…
The effect of dysmenorrhea severity and interference on reactions to experimentally-induced pain.
August 3-9, 2024 | |
Source: Front Pain Res (Lausanne) 2024; 5. doi: 10.3389/fpain.2024.1365193Authors: Rogers SK, Nichols KL, Ahamadeen N, Shanahan ML, Rand KL Dysmenorrhea is associated with increased risk of chronic pain and hyperalgesia. Menstruating individuals with dysmenorrhea are more likely to have elevated pain reactivity when experiencing experimental…
Enhanced learning in migraine: False positive finding or discovery of a new migraine trait?
August 3-9, 2024 | |
Source: Cephalalgia 2024 Aug; 44(8). doi: 10.1177/03331024241268297Authors: Omland PM Pubmed ID: https://pubmed.ncbi.nlm.nih.gov/39109553/
Chronic Morphine Treatment Induces Sex- and Synapse-Specific Cellular Tolerance on Thalamo-Cortical Mu Opioid Receptor Signaling.
August 3-9, 2024 | |
Source: J Neurophysiol 2024 Aug 07; . doi: 10.1152/jn.00265.2024Authors: Jaeckel ER, Arias-Hervert ER, Perez-Medina AL, Schulz S, Birdsong WT How cellular adaptations give rise to opioid analgesic tolerance to opioids like morphine is not well understood. For one, pain is a complex phenomenon comprised of…
Enkephalin-mediated modulation of basal somatic sensitivity by regulatory T cells in mice.
August 3-9, 2024 | |
Source: Elife 2024 Aug 07; 13. doi: 10.7554/eLife.91359Authors: Aubert N, Purcarea M, Novarino J, Schopp J, Audibert A, Li W, Fornier M, Cagnet L, Naturel M, Casrouge A, Dieu-Nosjean MC, Blanchard N, Dietrich G, Peirs C, Marodon G CD4CD25Foxp3 regulatory T cells (Treg) have been…
Links Between Cellular Energy Metabolism and Pain Sensation.
August 3-9, 2024 | |
Source: Anesth Analg 2024 Aug 07; . doi: 10.1213/ANE.0000000000007096Authors: Li X, Zhao Z, Ke Y, Jiang Y, Liu Y, Liu Z One of the functions of organism cells is to maintain energy homeostasis to promote metabolism and adapt to the environment. The 3 major pathways…
Navigating virtual realities: identifying barriers and facilitators to implementing VR-enhanced PT for youth with chronic pain.
August 3-9, 2024 | |
Source: J Pediatr Psychol 2024 Aug 07; . doi: 10.1093/jpepsy/jsae056Authors: Jehl NM, Hess CW, Choate ES, Nguyen HT, Yang Y, Simons LE Virtual reality (VR) can enhance engagement in outpatient physical therapy (PT) through distraction and gamification of movement. This study assessed barriers and facilitators…
Development of Macrocyclic Neurotensin Receptor Type 2 (NTS2) Opioid-Free Analgesics.
August 3-9, 2024 | |
Source: Angew Chem Int Ed Engl 2024 Aug 07; . doi: 10.1002/anie.202405941Authors: Desgagné M, Chartier M, Lagard C, Ferková S, Choquette M, Longpré JM, Côté J, Boudreault PL, Sarret P The opioid crisis has highlighted the urgent need to develop non-opioid alternatives for managing pain,…
Prevalence of problematic pharmaceutical opioid use in patients with chronic non-cancer pain: A systematic review and meta-analysis.
August 3-9, 2024 | |
Source: Addiction 2024 Aug 07; . doi: 10.1111/add.16616Authors: Thomas KH, Dalili MN, Cheng HY, Dawson S, Donnelly N, Higgins JPT, Hickman M Chronic non-cancer pain (CNCP) is one of the most common causes of disability globally. Opioid prescribing to treat CNCP remains widespread, despite limited…