August 12-18, 2023
Showing 1-25 of 123.
PIEZO2 in somatosensory neurons controls gastrointestinal transit
Source: Cell 3 August; 186(16). doi: 10.1016/j.cell.2023.07.006 Authors: M. Rocio Servin-Vences, Ruby M. Lam, Alize Koolen, Yu Wang, Dimah N. Saade, Meaghan Loud, Halil Kacmaz, Suzanne Frausto, Yunxiao Zhang, Arthur Beyder, Kara L. Marshall, Carsten G. Bönnemann, Alexander T. Chesler, Ardem Patapoutian The gastrointestinal tract…
Paradoxical heat sensation as a manifestation of thermal hypesthesia: a study of 1090 patients with lesions of the somatosensory system.
Source: Pain 2023 Aug 11;. doi: 10.1097/j.pain.0000000000003014 Authors: Vollert J, Fardo F, Attal N, Baron R, Bouhassira D, Enax-Krumova EK, Freynhagen R, Hansson P, Jensen TS, Kersebaum D, Maier C, Pogatzki-Zahn E, Rice ASC, Sachau J, Schaldemose EL, Segerdahl M, Sendel M, Tölle TR, Finnerup…
Neural Correlates of Pain-Autonomic Coupling in Patients With Complex Regional Pain Syndrome Treated by Repetitive Transcranial Magnetic Stimulation of the Motor Cortex.
Source: Neuromodulation 2023 Aug 16; . doi: 10.1016/j.neurom.2023.05.005Authors: Delon-Martin C, Lefaucheur JP, Hodaj E, Sorel M, Dumolard A, Payen JF, Hodaj H Complex regional pain syndrome (CRPS) is a chronic pain condition involving autonomic dysregulation. In this study, we report the results of an ancillary…
Multiphase Spinal Cord Stimulation in Participants With Chronic Back or Leg Pain: Results of the BENEFIT-02 Randomized Clinical Trial.
Source: Neuromodulation 2023 Aug 16; . doi: 10.1016/j.neurom.2023.05.006Authors: Kapural L, Patterson DG, Li S, Hatheway J, Hunter C, Rosen S, Fishman M, Gupta M, Sayed D, Christopher A, Burgher A, McJunkin T, Ross EL, Provenzano D, Amirdelfan K This study aimed to assess the safety…
The Effect of Transcutaneous Posterior Tibial Nerve Stimulation on Pain and Quality of Life in Patients with Fibromyalgia: A Single-Blind, Randomized Controlled Trial.
Source: J Clin Med 2023 Jul 29; 12(15). doi: 10.3390/jcm12154989Authors: Sarı İF, İlhanlı İ, Mızrak T, Kulaklı F, Kasap Z This study aimed to investigate the effectiveness of posterior tibial nerve stimulation (PTNS) in reducing pain, improving quality of life, and decreasing disease severity in…
Temporally complex inflammatory networks in an animal model reveal signatures for interstitial cystitis and bladder pain syndrome phenotype.
Source: Neurourol Urodyn 2023 Aug 17; . doi: 10.1002/nau.25267Authors: Shah AM, Vodovotz Y, Yoshimura N, Chermansky CJ, Fitzgerald J, Tyagi P Interstitial cystitis and bladder pain syndrome (IC/BPS) presents with symptoms of debilitating bladder pain and is typically a diagnosis of exclusion. The cystoscopic detection…
Digital screening method using social media advertising for the remote assessment of trigeminal neuralgia.
Source: Digit Health 2023; 9. doi: 10.1177/20552076231194913Authors: Chen FB, Barbosa DA Global trends, such as improving accessibility to healthcare services through the Internet, and the COVID-19 pandemic are among the driving factors in the adoption of digital health. This study hypothesized that digital solutions can…
Antinociceptive properties of losmapimod in two acute pain models in rats: behavioural analysis, immunohistochemistry, dose response, and comparison with usual analgesic drugs.
Source: BJA Open 2022 Sep; 3. doi: 10.1016/j.bjao.2022.100029Authors: Soued M, Hamdi L, Ben Rehouma M, Mazoit JX, Benhamou D The p38 protein is a ubiquitous mitogen-activated protein kinase involved in the proinflammatory signalling pathway and in the pain response after various noxious stimuli. Many p38…
Percutaneous Electrical Nerve Field Stimulation in Children and Adolescents With Functional Dyspepsia-Integrating a Behavioral Intervention.
Source: Neuromodulation 2023 Aug 16; . doi: 10.1016/j.neurom.2023.07.005Authors: Santucci NR, Beigarten AJ, Khalid F, El-Chammas KI, Graham K, Sahay R, Fei L, Rich K, Mellon M Functional dyspepsia (FD) includes postprandial distress and epigastric pain syndrome. Percutaneous electrical nerve field stimulation (PENFS) in addition to…
Early Clinical Results of Intervertebral Joint Stabilization by Injectable Load-Sharing Polymers.
Source: J Pain Res 2023; 16. doi: 10.2147/JPR.S413104Authors: Hedman T, Yu J, Singh H, Deer T Genipin is a polymer-forming collagen bonding substance that can be dissolved in a buffered carrier and injected into disc annulus tissues. Therapeutic benefit is derived from the mechanical support…
Cav3.2 T-Type calcium channels downregulation attenuates bone cancer pain induced by inhibiting IGF-1/HIF-1α signaling pathway in the rat spinal cord.
Source: J Bone Oncol 2023 Oct; 42. doi: 10.1016/j.jbo.2023.100495Authors: Liu Q, Lu Z, Ren H, Fu L, Wang Y, Bu H, Ma M, Ma L, Huang C, Wang J, Zang W, Cao J, Fan X Bone cancer pain (BCP) is one of the most ubiquitous…
The Synergistic Effects of 5-HT2A and TRP Agonism/Antagonism in Reducing Inflammation for Enhanced Mental and Physical Health.
Source: ACS Med Chem Lett 2023 Aug 10; 14(8). doi: 10.1021/acsmedchemlett.3c00276Authors: Kargbo RB Depression is a widespread issue in the United States and the leading cause of disability globally, impacting people of all ages. Although selective serotonin reuptake inhibitors (SSRIs) are commonly used for treatment,…
Prolonged Antipruritic Effect of Botulinum Toxin Type A on Cowhage-induced Itch: A Randomized, Single-blind, Placebo-controlled Trial.
Source: Acta Derm Venereol 2023 Aug 16; 103. doi: 10.2340/actadv.v103.6581Authors: Nattkemper LA, Vander Does A, Stull CM, Lavery MJ, Valdes-Rodriguez R, McGregory M, Chan YH, Yosipovitch G Botulinum toxin type A (Botox) is thought to have antipruritic effects through inhibition of pruritic factors, including acetylcholine,…
Examining the role of mood in pain-limited treadmill walking duration in young healthy individuals.
Source: Eur J Pain 2023 Aug 16; . doi: 10.1002/ejp.2170Authors: Lu J, Bisset LM, Shaw K, Sharma P, Morris NR The purpose of the study was to examine the effects of acute mood modulation on treadmill walking duration during experimental pain application. Pubmed ID: https://pubmed.ncbi.nlm.nih.gov/37584244/
Non-CGRP Antagonist/Non-Triptan Options for Migraine Disease Treatment: Clinical Considerations.
Source: Curr Pain Headache Rep 2023 Aug 16; . doi: 10.1007/s11916-023-01151-0Authors: Ingram EE, Bocklud BE, Corley SC, Granier MA, Neuchat EE, Ahmadzadeh S, Shekoohi S, Kaye AD Although the association between CGRP and migraine disease is well-known and studied, therapies can target other pathways to…
Psychological Flexibility, Chronic Pain, and Health.
Source: Annu Rev Psychol 2023 Aug 16; . doi: 10.1146/annurev-psych-020223-124335Authors: McCracken LM Psychological flexibility is a model of human performance and well-being. It essentially entails an approach to life circumstances that includes openness, awareness, and engagement. It has roots in behavior analysis, and it is…
Predicting direct healthcare costs of general practitioner-guided care in patients with musculoskeletal complaints.
Source: Pain 2023 Aug 15; . doi: 10.1097/j.pain.0000000000003028Authors: Pellekooren S, Ben ÂJ, van Dongen JM, Pool-Goudzwaard AL, van Tulder MW, van den Berg JM, Ostelo RWJG Information on healthcare utilization and costs of general practitioner (GP)-guided care in patients with musculoskeletal complaints is important for…
Caring for Our Patients With Opioid Use Disorder in the Perioperative Period: A Guide for the Anesthesiologist.
Source: Anesth Analg 2023 Sep 01; 137(3). doi: 10.1213/ANE.0000000000006280Authors: Barreveld AM, Mendelson A, Deiling B, Armstrong CA, Viscusi ER, Kohan LR Opioid use disorder (OUD) is a rising public health crisis, impacting millions of individuals and families worldwide. Anesthesiologists can play a key role in…
Substance Use Disorders: Basic Overview for the Anesthesiologist.
Source: Anesth Analg 2023 Sep 01; 137(3). doi: 10.1213/ANE.0000000000006281Authors: Jimenez Ruiz F, Warner NS, Acampora G, Coleman JR, Kohan L Substance use disorders (SUDs) represent a current major public health concern in the United States and around the world. Social and economic stressors secondary to…
The effectiveness of exercise and physical activity programs on fatigue and sleep in people with arthritis – A systematic review with meta-analysis.
Source: Sleep Med Rev 2023 Aug 07; 71. doi: 10.1016/j.smrv.2023.101832Authors: Runge N, Arribas-Romano A, Labie C, Mairesse O, Goossens Z, Nijs J, Malfliet A, Verschueren S, Van Assche D, de Vlam K, De Baets L This systematic review aimed to systematically investigate the literature on…
The association between racialized discrimination in healthcare and pain among Black patients with mental health diagnoses.
Source: J Pain 2023 Aug 15; . doi: 10.1016/j.jpain.2023.08.004Authors: Hammett PJ, Eliacin J, Saenger M, Allen KD, Meis LA, Krein SL, Taylor BC, Branson M, Fu SS, Burgess DJ Chronic pain is a costly and debilitating problem in the US, and its burdens are exacerbated…
Differential Effects of Thermal Stimuli in Eliciting Temporal Contrast Enhancement: A Psychophysical Study.
Source: J Pain 2023 Aug 15; . doi: 10.1016/j.jpain.2023.08.005Authors: Luebke L, von Selle J, Adamczyk WM, Knorr M, Carvalho GF, Gouverneur P, Luedtke K, Szikszay TM Offset analgesia (OA) is observed when pain relief is disproportional to the reduction of noxious input and is based…
Ligand recognition and G protein coupling of the human itch receptor MRGPRX1.
Source: Nat Commun 2023 Aug 17; 14(1). doi: 10.1038/s41467-023-40705-zAuthors: Guo L, Zhang Y, Fang G, Tie L, Zhuang Y, Xue C, Liu Q, Zhang M, Zhu K, You C, Xu P, Yuan Q, Zhang C, Liu L, Rong N, Peng S, Liu Y, Wang C,…
POU2F1/DNMT3a Pathway Participates in Neuropathic Pain by Hypermethylation-Mediated LRFN4 Downregulation Following Oxaliplatin Treatment.
Source: Neurochem Res 2023 Aug 18; . doi: 10.1007/s11064-023-04011-wAuthors: Gu YH, Wang J, Lu WC, Cheng Y, Tao R, Zhang SJ, Xu T, Zhai KW, Luo SX, Xin WJ Evidence demonstrates that DNA methylation is associated with the occurrence and development of various neurological diseases….
Headache disorders and relevant sex and socioeconomic patterns in adolescents and young adults across 204 countries and territories: an updated global analysis.
Source: J Headache Pain 2023 Aug 18; 24(1). doi: 10.1186/s10194-023-01648-4Authors: Ge R, Chang J, Cao Y Primary headache disorders are a group of highly prevalent and disabling neurological diseases that mainly consist of migraine and tension-type headache (TTH). A previous study showed that the burden…