April 15-21, 2023
Showing 1-25 of 104.
Plasticity in ventral pallidal cholinergic neuron-derived circuits contributes to comorbid chronic pain-like and depression-like behaviour in male mice.
Source: Nat Commun 2023 Apr 17; 14(1). doi: 10.1038/s41467-023-37968-x Authors: Ji YW, Shen ZL, Zhang X, Zhang K, Jia T, Xu X, Geng H, Han Y, Yin C, Yang JJ, Cao JL, Zhou C, Xiao C Nucleus- and cell-specific interrogation of individual basal forebrain (BF)…
The basolateral amygdala-anterior cingulate pathway contributes to depression-like behaviors and comorbidity with chronic pain behaviors in male mice.
Source: Nat Commun 2023 Apr 17; 14(1). doi: 10.1038/s41467-023-37878-y Authors: Becker LJ, Fillinger C, Waegaert R, Journée SH, Hener P, Ayazgok B, Humo M, Karatas M, Thouaye M, Gaikwad M, Degiorgis L, Santin MDN, Mondino M, Barrot M, Ibrahim EC, Turecki G, Belzeaux R, Veinante…
Distinct serum immune profiles define the spectrum of acute and chronic pancreatitis from the multi-center PROCEED study.
Source: Gastroenterology 2023 Apr 13;. doi: 10.1053/j.gastro.2023.03.236 Authors: Lee B, Jones EK, Manohar M, Li L, Yadav D, Conwell DL, Hart PA, Vege SS, Fogel EL, Serrano J, Andersen D, Bellin MD, Topazian M, Van Den Eeden SK, Pandol SJ, Forsmark C, Fisher WE, Park…
Piezo2 regulates colonic mechanical sensitivity in a sex specific manner in mice.
Source: Nat Commun 2023 Apr 15; 14(1). doi: 10.1038/s41467-023-37683-7 Authors: Madar J, Tiwari N, Smith C, Sharma D, Shen S, Elmahdi A, Qiao LY The mechanosensitive ion channel Piezo2 in mucosa and primary afferents transduces colonic mechanical sensation. Here we show that chemogenetic activation or…
Efficacy and Safety of Tralokinumab in Adolescents With Moderate to Severe Atopic Dermatitis: The Phase 3 ECZTRA 6 Randomized Clinical Trial.
Source: JAMA Dermatol 2023 Apr 19; . doi: 10.1001/jamadermatol.2023.0627Authors: Paller AS, Flohr C, Cork M, Bewley A, Blauvelt A, Hong HC, Imafuku S, Schuttelaar MLA, Simpson EL, Soong W, Arlert P, Lophaven KW, Kurbasic A, Soldbro L, Vest NS, Wollenberg A Safe and effective long-term…
Efficacy and safety of Diclofenac sodium plaster in patients with acute pain of the limbs: a randomized, placebo and active-controlled, double-blind, parallel-group trial.
Source: Eur Rev Med Pharmacol Sci 2023 Apr; 27(7). doi: 10.26355/eurrev_202304_31952Authors: Pabst H, Gruber G, Picciotto R, Barbaro B, Giordan N The aim of the present study was to assess the safety and efficacy of Diclofenac sodium (DS) 140 mg medicated plaster vs. Diclofenac epolamine…
Macrophages and small extracellular vesicle mediated-intracellular communication in the peritoneal microenvironment: Impact on endometriosis development.
Source: Front Reprod Health 2023; 5. doi: 10.3389/frph.2023.1130849Authors: Wang Y, Dragovic RA, Greaves E, Becker CM, Southcombe JH Endometriosis is an inflammatory disease that is defined as the growth of endometrium-like tissue outside the uterus, commonly on the lining of the pelvic cavity, visceral organs…
Effects of Intradermal Botulinum Toxin Injections on Herpes Zoster Related Neuralgia.
Source: Infect Drug Resist 2023; 16. doi: 10.2147/IDR.S401972Authors: Peng F, Xia TB Postherpetic neuralgia (PHN), which represents the most common chronic complication of herpes zoster, is characterized by intense pain and is difficult to treat. In fact, no treatments are currently available that can effectively…
Generation of induced pluripotent stem cell line (UKWNLi008) derived from a patient carrying a c.1678C>G variant in the transient receptor potential cation channel subfamily A member (TRPA1) gene potentially associated with small fiber neuropathy.
Source: Stem Cell Res 2023 Apr 12; 69. doi: 10.1016/j.scr.2023.103094Authors: Schottmann NM, Klug K, Klopocki E, Üçeyler N Using human dermal fibroblasts (hdF) derived from a patient carrying a c.1678C>G variant located in the TRPA1 gene, induced pluripotent stem cells (iPSC) were generated. Cells were…
Structural MRI in Migraine: A Review of Migraine Vascular and Structural Changes in Brain Parenchyma.
Source: J Cent Nerv Syst Dis 2023; 15. doi: 10.1177/11795735231167868Authors: Xu WJ, Barisano G, Phung D, Chou B, Pinto SN, Lerner A, Sheikh-Bahaei N Migraine is a complex and common disorder that affects patients around the world. Despite recent advances in this field, the exact…
AdipoRon Engages Microglia to Antinociception through the AdipoR1/AMPK Pathway in SNI Mice.
Source: Mediators Inflamm 2023; 2023. doi: 10.1155/2023/7661791Authors: Fang Q, Li J, Wang Y, Liu X, Shi Y, Chen J, Zhan H, Zeng Y, Wu W Microglia-associated neuroinflammation plays a crucial role in the initiation and development of neuropathic pain (NeuP). AdipoRon is an analog of…
Primary headache disorders: From pathophysiology to neurostimulation therapies.
Source: Heliyon 2023 Apr; 9(4). doi: 10.1016/j.heliyon.2023.e14786Authors: Wang Z, Yang X, Zhao B, Li W Primary headache disorders including migraine, cluster headache, and tension-type headache are among the most common disabling diseases worldwide. The unclear pathogenesis of primary headache disorders has led to high rates…
Psychiatric risk factors for chronic high-dose opioid prescribing: register-based cohort study.
Source: BJPsych Open 2023 Apr 20; 9(3). doi: 10.1192/bjo.2023.54Authors: van der Hoorn MMC, Kalkman GA, Weesie YM, Atsma F, Schellekens A Chronic high-dose (CHD) prescription opioid use is a major public health concern. Although CHD opioid use has been associated with psychiatric disorders, the causality…
Computational design and molecular modeling of morphine derivatives for preferential binding in inflamed tissue.
Source: Pharmacol Res Perspect 2023 Jun; 11(3). doi: 10.1002/prp2.1075Authors: Augenstein M, Alexander N, Gartner M The opioid epidemic has impacted over 10 million Americans in 2019. Opioids, like morphine, bind non-selectively in both peripheral tissue, leading to effective pain relief, and central tissue, resulting in dangerous…
Long COVID and especially headache syndromes.
Source: Curr Opin Neurol 2023 Apr 05; . doi: 10.1097/WCO.0000000000001153Authors: Tana C, Giamberardino MA, Martelletti P This is an expert overview on recent literature about the complex relationship between coronavirus disease 2019 (COVID-19) and headache. Pubmed ID: https://pubmed.ncbi.nlm.nih.gov/37078648/
Ultrastructure of dorsal root ganglia.
Source: Cell Tissue Res 2023 Apr 20; . doi: 10.1007/s00441-023-03770-wAuthors: Haberberger RV, Kuramatilake J, Barry CM, Matusica D Dorsal root ganglia (DRG) contains thousands of sensory neurons that transmit information about our external and internal environment to the central nervous system. This includes signals related…
Tannic acid, an IL-1β-direct binding compound, ameliorates IL-1β-induced inflammation and cartilage degradation by hindering IL-1β-IL-1R1 interaction.
Source: PLoS One 2023; 18(4). doi: 10.1371/journal.pone.0281834Authors: Lee HR, Jeong YJ, Lee JW, Jhun J, Na HS, Cho KH, Kim SJ, Cho ML, Heo TH Interleukin-1β (IL-1β) is one of the most potent pro-inflammatory cytokines implicated in a wide range of autoinflammatory, autoimmune, infectious, and…
TRPA1 rare variants in chronic neuropathic and nociplastic pain patients.
Source: Pain 2023 Apr 19; . doi: 10.1097/j.pain.0000000000002905Authors: Marchi M, Salvi E, Andelic M, Mehmeti E, D’Amato I, Cazzato D, Chiappori F, Lombardi R, Cartelli D, Devigili G, Dalla Bella E, Gerrits M, Almomani R, Malik RA, Ślęczkowska M, Mazzeo A, Gentile L, Dib-Hajj S,…
TRPM3 as a novel target to alleviate acute oxaliplatin-induced peripheral neuropathic pain.
Source: Pain 2023 Apr 19; . doi: 10.1097/j.pain.0000000000002906Authors: Aloi VD, Pinto SJPC, Van Bree R, Luyten K, Voets T, Vriens J Chemotherapy-induced peripheral neuropathic pain (CIPNP) is an adverse effect observed in up to 80% of patients of cancer on treatment with cytostatic drugs including…
Acute and sub-acute dermal toxicity of meloxicam emulgel: Analysis of biochemical, hematological, histopathological and immunohistochemical expression.
Source: Biochem Biophys Res Commun 2023 Apr 11; 660. doi: 10.1016/j.bbrc.2023.04.001Authors: Jyothi VGSS, Veerabomma H, Tryphena KP, Khatri DK, Singh SB, Madan J Meloxicam, a non-steroidal anti-inflammatory drug (NSAID) for the treatment of osteoarthritis. Despite being more effective against pain mediated by inflammation, it is…
Automatic extraction of social determinants of health from medical notes of chronic lower back pain patients.
Source: J Am Med Inform Assoc 2023 Apr 20; . doi: 10.1093/jamia/ocad054Authors: Lituiev DS, Lacar B, Pak S, Abramowitsch PL, De Marchis EH, Peterson TA We applied natural language processing and inference methods to extract social determinants of health (SDoH) information from clinical notes of…
Physical functioning following spinal cord stimulation: a systematic review and meta-analysis.
Source: Reg Anesth Pain Med 2023 Jun; 48(6). doi: 10.1136/rapm-2022-104295Authors: ElSaban M, Kleppel DJ, Kubrova E, Martinez Alvarez GA, Hussain N, D’Souza RS Spinal cord stimulation (SCS) has emerged as an important treatment for chronic pain disorders. While there is evidence supporting improvement in pain…
Daring discourse: economics of neuromodulation for the treatment of persistent spinal pain syndrome and complex regional pain syndrome.
Source: Reg Anesth Pain Med 2023 Jun; 48(6). doi: 10.1136/rapm-2022-103887Authors: Provenzano DA, Heller JA The treatment options for patients with chronic pain conditions are impacted by recent research, patient needs, and insurance coverage. Although various factors affect the cost of healthcare, the economic burden on…
The Pharmacokinetics of Subcutaneous Methylnaltrexone Bromide in Rhesus Macaques ().
Source: J Am Assoc Lab Anim Sci 2023 Apr 20; . doi: 10.30802/AALAS-JAALAS-22-000111Authors: Jepkes S, Josee-Lemoy M, Knych H, de Lucena T, Ardeshir A, Stockinger DE Opioids are an integral component of pain management for nonhuman primates. These potent analgesics also adverse gastrointestinal (GI) effects…
Measurement properties of 72 movement biomarkers aiming to discriminate non‑specific chronic low back pain patients from an asymptomatic population.
Source: Sci Rep 2023 Apr 20; 13(1). doi: 10.1038/s41598-023-33504-5Authors: Moissenet F, Armand S, Genevay S The identification of relevant and valid biomarkers to distinguish patients with non-specific chronic low back pain (NSCLBP) from an asymptomatic population in terms of musculoskeletal factors could contribute to patient…