April 13-19, 2024
Showing 1-25 of 112.
CXCL5 activates CXCR2 in nociceptive sensory neurons to drive joint pain and inflammation in experimental gouty arthritis.
Source: Nat Commun 2024 Apr 16; 15(1). doi: 10.1038/s41467-024-47640-7 Authors: Yin C, Liu B, Dong Z, Shi S, Peng C, Pan Y, Bi X, Nie H, Zhang Y, Tai Y, Hu Q, Wang X, Shao X, An H, Fang J, Wang C, Liu B Gouty…
Nociceptor spontaneous activity is responsible for fragmenting non-rapid eye movement sleep in mouse models of neuropathic pain.
Source: Sci Transl Med 2024 Apr 17; 16(743). doi: 10.1126/scitranslmed.adg3036 Authors: Alexandre C, Miracca G, Holanda VD, Sharma A, Kourbanova K, Ferreira A, Bicca MA, Zeng X, Nassar VA, Lee S, Kaur S, Sarma SV, Sacré P, Scammell TE, Woolf CJ, Latremoliere A Spontaneous pain,…
Complex regional pain syndrome: advances in epidemiology, pathophysiology, diagnosis, and treatment.
Source: Lancet Neurol 2024 May; 23(5). doi: 10.1016/S1474-4422(24)00076-0 Authors: Ferraro MC, O’Connell NE, Sommer C, Goebel A, Bultitude JH, Cashin AG, Moseley GL, McAuley JH Complex regional pain syndrome (CRPS) is a rare pain disorder that usually occurs in a limb after trauma. The features…
Sortilin-Mediated Inhibition of TREK1/2 Channels in Primary Sensory Neurons Promotes Prediabetic Neuropathic Pain.
Source: Adv Sci (Weinh) 2024 Apr 16;. doi: 10.1002/advs.202310295 Authors: Sun W, Yang F, Wang Y, Yang Y, Du R, Wang XL, Luo ZX, Wu JJ, Chen J Neuropathic pain can occur during the prediabetic stage, even in the absence of hyperglycemia. The presence of…
The effects of telehealth-delivered mindfulness meditation, cognitive therapy, and behavioral activation for chronic low back pain: a randomized clinical trial.
Source: BMC Med 2024 Apr 12; 22(1). doi: 10.1186/s12916-024-03383-2Authors: Day MA, Ciol MA, Mendoza ME, Borckardt J, Ehde DM, Newman AK, Chan JF, Drever SA, Friedly JL, Burns J, Thorn BE, Jensen MP Chronic low back pain (CLBP) is a significant problem affecting millions of…
Differences in Cortical Morphology in People With and Without Migraine: A Registry for Migraine (REFORM) MRI Study.
Source: Neurology 2024 May; 102(9). doi: 10.1212/WNL.0000000000209305Authors: Christensen RH, Ashina H, Al-Khazali HM, Zhang Y, Tolnai D, Poulsen AH, Cagol A, Hadjikhani N, Granziera C, Amin FM, Ashina M Structural imaging can offer insights into the cortical morphometry of migraine, which might reflect adaptations to…
Effects of PDE-3 inhibition in persistent post-traumatic headache: evidence of cAMP-dependent signaling.
Source: J Headache Pain 2024 Apr 17; 25(1). doi: 10.1186/s10194-024-01762-xAuthors: Al-Khazali HM, Christensen RH, Chaudhry BA, Melchior AG, Ashina M, Burstein R, Ashina H Phosphodiesterase 3 (PDE-3) inhibition have been implicated in the neurobiologic underpinnings of migraine. Considering the clinical similarities between migraine and persistent…
Astrocyte activation in hindlimb somatosensory cortex contributes to electroacupuncture analgesia in acid-induced pain.
Source: Front Neurol 2024; 15. doi: 10.3389/fneur.2024.1348038Authors: Ye Q, Li J, Ren WJ, Zhang Y, Wang T, Rubini P, Yin HY, Illes P, Tang Y Several studies have confirmed the direct relationship between extracellular acidification and the occurrence of pain. As an effective pain management…
Santacruzamate A Alleviates Pain and Pain-Related Adverse Emotions through the Inhibition of Microglial Activation in the Anterior Cingulate Cortex.
Source: ACS Pharmacol Transl Sci 2024 Apr 12; 7(4). doi: 10.1021/acsptsci.3c00282Authors: Qin Y, Liu Q, Wang S, Wang Q, Du Y, Yao J, Chen Y, Yang Q, Wu Y, Liu S, Zhao M, Wei G, Yang L Chronic pain is a complex disease. It seriously…
Migraine and Its Treatment from the Medicinal Chemistry Perspective.
Source: ACS Pharmacol Transl Sci 2024 Apr 12; 7(4). doi: 10.1021/acsptsci.3c00370Authors: Pehlivanlar E, Carradori S, Simsek R Migraine is a disease of neurovascular origin that affects the quality of life of more than one billion people and ranks sixth among the most common diseases in…
A Systematic Guideline by the ASPN Workgroup on the Evidence, Education, and Treatment Algorithm for Painful Diabetic Neuropathy: SWEET.
Source: J Pain Res 2024; 17. doi: 10.2147/JPR.S451006Authors: Sayed D, Deer TR, Hagedorn JM, Sayed A, D’Souza RS, Lam CM, Khatri N, Hussaini Z, Pritzlaff SG, Abdullah NM, Tieppo Francio V, Falowski SM, Ibrahim YM, Malinowski MN, Budwany RR, Strand NH, Sochacki KM, Shah A,…
Personality systems interactions theory: an integrative framework complementing the study of the motivational and volitional dynamics underlying adjustment to chronic pain.
Source: Front Pain Res (Lausanne) 2024; 5. doi: 10.3389/fpain.2024.1288758Authors: Kästner A, Petzke F In the endeavor to advance our understanding of interindividual differences in dealing with chronic pain, numerous motivational theories have been invoked in the past decade. As they focus on relevant, yet different…
Nonspecific oral medications versus anti-calcitonin gene-related peptide monoclonal antibodies for migraine: A systematic review and meta-analysis of randomized controlled trials.
Source: Headache 2024 Apr 18; . doi: 10.1111/head.14693Authors: Robblee J, Hakim SM, Reynolds JM, Monteith TS, Zhang N, Barad M To compare calcitonin gene-related peptide monoclonal antibodies (CGRP mAbs) versus nonspecific oral migraine preventives (NOEPs). Pubmed ID: https://pubmed.ncbi.nlm.nih.gov/38634515/
Depression and anxiety are not associated with migraine outcomes in children and adolescents.
Source: Headache 2024 Apr 18; . doi: 10.1111/head.14700Authors: Gelfand AA Pubmed ID: https://pubmed.ncbi.nlm.nih.gov/38634622/
Focused Update on Migraine and Vertigo Comorbidity.
Source: Curr Pain Headache Rep 2024 Apr 18; . doi: 10.1007/s11916-024-01256-0Authors: Huang TC, Arshad Q, Kheradmand A To provide an update on comorbidity of vestibular symptoms and migraine. Pubmed ID: https://pubmed.ncbi.nlm.nih.gov/38635020/
People with painful knee osteoarthritis hold negative implicit attitudes towards activity.
Source: Pain 2024 Apr 16; . doi: 10.1097/j.pain.0000000000003210Authors: Pulling BW, Braithwaite FA, Mignone J, Butler DS, Caneiro JP, Lipp OV, Stanton TR Negative attitudes/beliefs surrounding osteoarthritis, pain, and activity contribute to reduced physical activity in people with knee osteoarthritis (KOA). These attitudes/beliefs are assessed using…
Painful distortions: people with painful knee osteoarthritis have biased visuospatial perception of the environment.
Source: Pain 2024 Apr 16; . doi: 10.1097/j.pain.0000000000003231Authors: MacIntyre E, Braithwaite FA, Stanton TR Visuospatial perception is thought to be adaptive-ie, hills are perceived as steeper when capacity is low, or threat is high-guiding appropriate interaction with the environment. Pain (bodily threat) may similarly modulate…
Barriers and enablers to exercise adherence in people with nonspecific chronic low back pain: a systematic review of qualitative evidence.
Source: Pain 2024 Apr 16; . doi: 10.1097/j.pain.0000000000003234Authors: Gilanyi YL, Shah B, Cashin AG, Gibbs MT, Bellamy J, Day R, McAuley JH, Jones MD Exercise is a first-line treatment for chronic low back pain (CLBP), reducing pain and disability in the short term. However, exercise…
Asymmetrical atrophy of the paraspinal muscles in patients undergoing unilateral lumbar medial branch radiofrequency neurotomy.
Source: Pain 2024 Mar 22; . doi: 10.1097/j.pain.0000000000003223Authors: Guven AE, Evangelisti G, Burkhard MD, Köhli P, Hambrecht J, Zhu J, Chiapparelli E, Kelly M, Tsuchiya K, Amoroso K, Zadeh A, Shue J, Tan ET, Sama AA, Girardi FP, Cammisa FP, Hughes AP Lumbar medial branch…
From taboo to treatment: The emergence of psychedelics in the management of pain and opioid use disorder.
Source: Br J Clin Pharmacol 2024 Apr 16; . doi: 10.1111/bcp.16045Authors: Weleff J, Nunes JC, Costa GPA, Sofuoglu M, MacLean RR, De Aquino JP The rise of psychedelics in contemporary medicine has sparked interest in their potential therapeutic applications. While traditionally associated with countercultural movements…
Distinct Functional Connectivity Patterns for Intermittent Vs Constant Neuropathic Pain Phenotypes in Persistent Spinal Pain Syndrome Type 2 Patients.
Source: J Pain Res 2024; 17. doi: 10.2147/JPR.S426640Authors: Pahapill PA, Arocho-Quinones EV, Chen G, Swearingen B, Tomas CW, Koch KM, Nencka AS Chronic low back pain (cLBP) has been associated with alterations in brain functional connectivity (FC) but based upon heterogeneous populations and single network analyses. Our…
Translation Research in Therapeutic Approaches from Conventional to Novel Nano-therapeutics for Rheumatoid Arthritis Treatment.
Source: Curr Rheumatol Rev 2024 Apr 15; . doi: 10.2174/0115733971288433240408062359Authors: Rani L, Mathur P, Verma R, Kumar V, Mishra AK, Sahoo PK Rheumatoid arthritis is a systemic autoimmune disorder related to joint inflammation, bone erosion, and deformity. Numerous studies indicate that the causes and consequences…
5HT2A modulation attenuates pancreatic cancer induced pain mouse model by inhibiting HDAC.
Source: Acta Cir Bras 2024; 39. doi: 10.1590/acb392324Authors: Fan W, Yang X, Zhou L, Xu J, Huang W, Tripathi AS Patients have been severely suffered from cancer associated pain, and pancreatic cancer is the most severe form of cancer associated with pain. There are very…
Mindfulness-Based Therapy for Military Populations with Chronic Pain: A Systematic Review.
Source: J Integr Complement Med 2024 Apr 17; . doi: 10.1089/jicm.2023.0343Authors: Chen HL, Li BH, Du YN, Jin ZF, Zhou LJ Due to the limited role of chronic pain medication in military personnel and the distress caused to the military population, mindfulness-based therapy has been…
Clinicians diagnosing virtual patients with the classification algorithm for chronic pain in the ICD-11 (CAL-CP) achieve better diagnoses and prefer the algorithm to standard tools: An experimental validation study.
Source: Eur J Pain 2024 Apr 17; . doi: 10.1002/ejp.2274Authors: Hay G, Korwisi B, Lahme-Hütig N, Rief W, Barke A The ICD-11 classification of chronic pain comprises seven categories, each further subdivided. In total, it contains over 100 diagnoses each based on 5-7 criteria. To…