Basic Research
Showing 1-25 of 4,021.
Targeting TLR4-Lipid Rafts Reverses Hyperexcitability in Pain-Associated Human Dorsal Root Ganglia
Source: The Journal of neuroscience : the official journal of the Society for Neuroscience Authors: Yan Li, Megan L Uhelski, Robert Y North, Claudio Esteves Tatsui, Hajira Elahi, Mario Heles, Juliana M Navia-Pelaez, Christopher B Bankston, German Corrales, Nicolas A Cortes-Mejia, Juan P Cata, Luke…
A Systematic Review of Stem Cell Secretome-Derived Exosomes for Neuropathic Pain: Therapeutic Mechanisms and Translational Potential
Source: Molecular neurobiology Authors: Aidin Shahrezaei, Lili Dashti, Farinaz Nasirinezhad, Publication Date: Tue, 06 Oct 2026 06:00:00 -0400 Mol Neurobiol. 2026 Oct 6;63(1):950. doi: 10.1007/s12035-026-06225-9. ABSTRACT Neuropathic pain (NP) is a chronic disabling disorder with limited effective therapies. Exosomes isolated from the stem cell secretome…
Diversity and spatial segregation of TRP channels in the closest relatives of animals
Source: Proceedings of the National Academy of Sciences of the United States of America Authors: Simen Mannsåker, Pawel Burkhardt, Jeffrey Colgren, Publication Date: Wed, 07 Oct 2026 06:00:00 -0400 Proc Natl Acad Sci U S A. 2026 Oct 13;123(41):e2625484123. doi: 10.1073/pnas.2625484123. Epub 2026 Oct 7….
Long non-coding RNA Carip loss alters parabrachial synapses and drives pain hyposensitivity
Source: Brain : a journal of neurology Authors: Feng Xu, Ruijin Zhang, Yang Li, Hao Wang, Zhihua Zhao, Haidong Li, Xuefeng Shen, Peihua Chen, Xin Jin, Erzhong Wu, Xiaoli Cui, Dongdong Zhang, Chao Li, Xiaomin Chen, Runsheng Chen, Jianzhong Jeff Xi, Jianyuan Sun, Ye Yang,…
Multi-molecular adaptations of long-term opioid use in chronic pain
Source: Brain : a journal of neurology Authors: Marwan N Baliki, Andrew D Vigotsky, Gaelle Rached, Rami Jabakhanji, Lejian Huang, Paulo Branco, Joana Barroso, Olivia Cong, Maria Centeno, Sam Cermak, James Griffith, Ajay D Wasan, Thomas J Schnitzer, Apkar Vania Apkarian, Publication Date: Thu, 01…
Central infusion of prostaglandin E2 reveals a unified representation of sickness in the mouse insular cortex
Source: Current biology : CB Authors: Gretel B Kamm, Juan C Boffi, Muad Y Abd El Hay, Domitille Rajot, Ana Cukić, Martha N Havenith, Marieke Scholvinck, Nicolas Renier, Hiroki Asari, Robert Prevedel, Publication Date: Wed, 30 Sep 2026 06:00:00 -0400 Curr Biol. 2026 Sep 30:S0960-9822(26)01187-5….
Cell atlas of the developing human meninges reveals a dura-like nature of meningiomas
Source: Nature cell biology Authors: Elin Vinsland, Sergio Marco Salas, Ivana Kapustová, Lijuan Hu, Simone Webb, Xiaofei Li, Xiaoling He, Mats Nilsson, Muzlifah Haniffa, Roger A Barker, Oscar Persson, David R Raleigh, Erik Sundström, Peter Lönnerberg, Sten Linnarsson, Publication Date: Mon, 28 Sep 2026 06:00:00…
Spatially resolved multiomics of human meningeal development reveal lineage and disease dynamics
Source: Nature cell biology Authors: Ken To, J Patrick Pett, Olli Dufva, Nana-Jane Chipampe, Krzysztof Polanski, Ana-Maria Cujba, Kenny Roberts, Alexander V Predeus, Nadav Yayon, Kazumasa Kanemaru, Manal I Patel, David Horsfall, Tong Li, Pavel Mazin, Batuhan Cakir, Rakesh Kapuge, Alicja Wilk, Fani Memi, Xiaoling…
Sex-biased toll-like receptor 4 signaling in nociplastic pelvic pain
Source: Brain, behavior, and immunity Authors: Melissa E Lenert, Michel Pontari, Esmeralda Hildago-Lopez, J Quentin Clemens, Chelsea M Kaplan, Steven E Harte, Andrew Schrepf, Publication Date: Mon, 28 Sep 2026 06:00:00 -0400 Brain Behav Immun. 2026 Sep 28:107032. doi: 10.1016/j.bbi.2026.107032. Online ahead of print. ABSTRACT…
A molecular and spinal circuit basis for the functional segregation of itch and pain
Source: Neuron Authors: Myung-Chul Noh, Kelly A Corrigan, Sean-Paul G Williams, Cedric Peirs, Michael J Leone, Daniel J Headrick, Mustafa Guvercin, Suhjin Lee, BaDoi N Phan, Xinyi Zhao, David A Henry, Deepika Yeramosu, Sudhagar Babu, Ashley R Brown, Robert Van De Weerd, Richard P Dum,…
A microglial SPP1-ITGB1 feedback loop sustains thalamic hyperexcitability and post-stroke pain
Source: Neuron Authors: Ruicheng Dai, Wenting Wu, Xiangyu Zhou, Yu Zhou, Xinwei Gao, Minmin Luo, Publication Date: Mon, 28 Sep 2026 06:00:00 -0400 Neuron. 2026 Sep 28:S0896-6273(26)00679-3. doi: 10.1016/j.neuron.2026.08.028. Online ahead of print. ABSTRACT Central post-stroke pain (CPSP) represents a failure of homeostatic recovery, yet…
Myeloid AEG-1 regulates the initiation of chronic inflammatory pain responses in the CFA mouse model
Source: Brain, behavior, and immunity Authors: Bryan D Mckiver, Deniz Bagdas, Lauren V Moncayo, Torin A Honaker, Eda Köşeli, Sara M Herz, Rachel Mendoza, Jolene J Windle, Devanand Sarkar, M Imad Damaj, Publication Date: Sat, 26 Sep 2026 06:00:00 -0400 Brain Behav Immun. 2026 Sep…
STING-IL-6 signaling in sensory neurons drives cisplatin-induced neuropathic pain
Source: Brain, behavior, and immunity Authors: Fabio B Andrade, Beatriz L Adjafre, Yasmin Sahlloul, Sang Hoon Lee, Francisco I Gomes-Aragão, Atlante S Mendes, Conceição Elidianne A Silva, Gabriel V Lucena-Silva, Arthur Silveira Prudente, Fernando Q Cunha, José C Alves-Filho, Bernhard Ryffel, Temugin Berta, Thiago M…
Sex-specific spinal neurotrophin receptors mediate chronic stress-induced tactile allodynia in rats
Source: The journal of pain Authors: María José Escoto-Rosales, Andrea Crisóstomo-Jiménez, Juan Miguel Pizaña-Encarnación, Rosa Estefanía Guerrero-Morán, Erika Curiel-Gómez, Erick J Rodríguez-Palma, Ana M Islas-Espinoza, José Jaime Herrera-Pérez, Alonso Fernández-Guasti, Nadia L Caram-Salas, Crystell G Guzmán-Priego, Vinicio Granados-Soto, Publication Date: Sat, 26 Sep 2026 06:00:00…
Tangeretin attenuates diabetes-induced neuropathic pain in rats: Evidence for adrenoceptor involvement
Source: Neuropharmacology Authors: Gamze Tokgöz Tekin, Gizem Türkoğlu Sağlık, Cevşen Yazıcı Şenocak, Ümide Demir Özkay, Özgür Devrim Can, Publication Date: Fri, 25 Sep 2026 06:00:00 -0400 Neuropharmacology. 2026 Sep 25;301:111200. doi: 10.1016/j.neuropharm.2026.111200. Online ahead of print. ABSTRACT In this study, the efficacy of tangeretin, a…
Addiction-like behavioral severity predicts prolonged oxycodone withdrawal-induced allodynia in genetically diverse rats
Source: Neuropharmacology Authors: Sonja L Plasil, Lani Tieu, Chengjia Qian, Natalie Taylor, Stella Coe, Elizabeth Sneddon, Lieselot Lg Carrette, Molly Brennan, Alex Morgan, Dyar Othman, Kathleen Bai, Sara Foroutani, Giordano de Guglielmo, Marsida Kallupi, Olivier George, Publication Date: Fri, 25 Sep 2026 06:00:00 -0400 Neuropharmacology….
Direct cellular contact by Porphyromonas gingivalis suppresses nociceptor excitability and induces analgesia during inflammation
Source: Science advances Authors: Sena Chung, Doyun Kim, Byeonggeon Koh, Yeon Kyeong Ko, Kihwan Lee, Hayun Kim, Hyun Young Kim, Manda Yu, Ozge Erdogan, Larissa Staurengo-Ferrari, Isaac M Chiu, Mary E Davey, Youngnim Choi, Seog Bae Oh, Publication Date: Fri, 25 Sep 2026 06:00:00 -0400…
Epidermal microstructure and tactile sensitivity in the glabrous skin of hands and feet
Source: Journal of neurophysiology Authors: James Re Hall, Gabriela Gonzalez Salas Duhne, Olivia M Wallis, Clare Howarth, Hannes P Saal, Publication Date: Fri, 25 Sep 2026 06:00:00 -0400 J Neurophysiol. 2026 Sep 25. doi: 10.1152/jn.00279.2026. Online ahead of print. ABSTRACT Glabrous skin on the human…
Ultraviolet-B sensitizes silent nociceptors and desensitizes C-touch fibers to slow depolarizing electrical stimuli in pigs
Source: Pain reports Authors: Sabrina Soares, Martin Schmelz, Roman Rukwied, Publication Date: Fri, 21 Aug 2026 06:00:00 -0400 Pain Rep. 2026 Aug 19;11(5):e1491. doi: 10.1097/PR9.0000000000001491. eCollection 2026 Oct. ABSTRACT INTRODUCTION: Tetrodotoxin-resistant voltage-sensitive sodium channel subtypes 1.8 and 1.9 play a key role on “silent” (mechano-insensitive)…
Two pore domain THIK2 potassium channels regulate acute and chronic pain signaling
Source: Pain reports Authors: Nicolas Gilbert, Franck C Chatelain, Solène Gibaud, Thomas Lorivel, Ying-Ling Shen, Marie-Emmanuelle Kerros, Sylvain Feliciangeli, Frederic Fiore, Chih-Cheng Chen, Florian Lesage, Delphine Bichet, Publication Date: Fri, 21 Aug 2026 06:00:00 -0400 Pain Rep. 2026 Aug 19;11(5):e1481. doi: 10.1097/PR9.0000000000001481. eCollection 2026 Oct….
A glutamatergic S1-VPL-S1 corticothalamocortical loop amplifies mechanical hypersensitivity in neuropathic pain
Source: Pain Authors: Yujiao Hu, Hao Ding, Lijing Zou, Zhuo Wen, Hongming Wu, Tingting Ni, Lin He, Qi Gao, Han Cao, Junyu Zhou, Jiajun Chen, Baochun Jiang, Shuang Qiu, Lina Yu, Min Yan, Publication Date: Tue, 28 Jul 2026 06:00:00 -0400 Pain. 2026 Oct 1;167(10):2350-2364….
Macrophage migration inhibitory factor antagonist ISO-1 reduces neuroinflammation and neuropathic pain in a sex-dependent manner
Source: Pain Authors: Monica Pontearso, Anirban Bhattacharyya, Pavel Adamek, Daniel Vasconcelos, Jakub Slepicka, Mario Heles, Diana Spicarova, Jiri Palecek, Publication Date: Mon, 20 Jul 2026 06:00:00 -0400 Pain. 2026 Oct 1;167(10):2336-2349. doi: 10.1097/j.pain.0000000000004066. Epub 2026 Jul 21. ABSTRACT Peripheral neuropathy is a global health concern…
Study on the effect and mechanism of sesamin on P2X3-related cheek allergic contact dermatitis in mice induced by SADBE stimulation
Source: Neuropharmacology Authors: Xiaoqian Ma, Yuanyuan Zhang, Yuxin Yang, Yusen Sun, Shangdong Liang, Guilin Li, Publication Date: Fri, 29 May 2026 06:00:00 -0400 Neuropharmacology. 2026 Oct 1;297:111051. doi: 10.1016/j.neuropharm.2026.111051. Epub 2026 May 28. ABSTRACT Allergic contact dermatitis (ACD) is a common inflammatory skin condition characterized…
Novel targets in headache: A narrative review
Source: Headache Authors: Adriana Della Pietra, Peter J Goadsby, Carolina Oldoni, Stephen Silberstein, Fred Cohen, Simon Akerman, Publication Date: Tue, 29 Sep 2026 06:00:00 -0400 Headache. 2026 Sep 28. doi: 10.1111/head.70202. Online ahead of print. ABSTRACT OBJECTIVES/BACKGROUND: This narrative review summarizes novel applications for the…
Top down vs bottom up nociplastic pain
Source: Pain Authors: Andrew Schrepf, Daniel J Clauw, Publication Date: Tue, 08 Sep 2026 06:00:00 -0400 Pain. 2026 Oct 1;167(10):2231-2232. doi: 10.1097/j.pain.0000000000004100. Epub 2026 Aug 27. NO ABSTRACT PMID:42708330 | DOI:10.1097/j.pain.0000000000004100 Pubmed ID: pubmed:42708330 Identifiers: pmid:42708330, doi:10.1097/j.pain.0000000000004100,