We recently discovered that growth factor inhibition completely eliminates opioid tolerance. We also discovered an important reason why opioids are ineffective against neuropathic pain and demonstrated a mechanistic link between pain and tolerance. However, we still do not fully understand the mechanisms underlying these remarkable effects. There are many opportunities for creative, driven individuals to make seminal contributions early in their careers. We are attacking these problems using Drosophila and mouse genetics, signal transduction assays, and proteomics, as well as advanced behavioral and neuroanatomical techniques. We interact with stimulating collaborators in a high caliber research environment at the world-renowned Pittsburgh Center for Pain Research.
Babcock DT, Shi S, Jo J, Shaw M, Gutstein HB, Galko MJ.
Curr Biol. 2011 Sep 27; 21(18):1525-33. Epub 2011 Sep 08.
PMID: 21906949. Abstract
Wang Y, Barker K, Shi S, Diaz M, Mo B, Gutstein HB
Nat Med. 2012 Mar; 18(3):385-7. Epub 2012 Feb 19.
Donica CL, Cui Y, Shi S, Gutstein HB
PLoS One. 2014; 9(5):e97105. Epub 2014 May 12.
Please send your CV, a summary of research experience, and the names and contact information for three references to:
Departments of Anesthesiology and Neurobiology
University of Pittsburgh School of Medicine
A-1305 Scaife Hall
3550 Terrace Street
Pittsburgh, PA 15261 USA