Apr 19 2017
RNA sequencing in multiple connected brain regions identifies large number of genes underlying pain-depression connection; new study will serve as resource for future work
news Research
Apr 06 2017
Activation of G protein-coupled receptor in central terminals dampens pain in “humanized” mice
news Research
Mar 23 2017
NFEPP binds and activates mu-opioid receptors only at low pH, soothing pain in rats without typical side effects
news Drug Development | Research
Mar 15 2017
New “leaky gate” model helps explain how the two sensations are encoded in mice
news Research

Papers of the Week

Community & Resource Updates

6 May 2017 to 13 May 2017
Certosa di Pontignano, Siena, Italy

Community Updates Lower block


Apr 04 2017

PRF will host a webinar with Luana Colloca, University of Maryland School of Nursing, and School of Medicine, Baltimore, US, on...

Feb 28 2017

Sarah Linnstaedt, PhD, received her doctoral degree in 2008 from Georgetown University, Washington, DC, and then completed a postdoctoral...


Recent Comments

Apr 13 2017
This comment is co-authored by Andrey Ryabinin and Mary Heinricher, Oregon...
Apr 05 2017
By: Ke Ren
The authors report interesting findings that electro-acupuncture (EA) in...
Mar 22 2017
Conceptual illustration of Grp neuron function as a relief valve.
Mar 22 2017
By: Min Zhuo
In recent work by Brust et al., the authors report the identification of a...
Mar 20 2017
This is an excellent and very important article related to appropriate...
Jan 30 2017
I agree with Michael Gold’s comments pointing out that to accept the...
Jan 24 2017
Thank you for the publication and thanks to others for this lively...
Jan 22 2017
There are, of course, responses to all of the points Wood and Emery raised...
Jan 20 2017
Shades of Ramon y Cajal vs. Golgi! And once again, both Drs. Gold and Wood...
Jan 19 2017
By: John Wood
Editor’s note: This comment, written in response to Michael Gold...
Jan 19 2017
Okay―I admit it; it was the PRF tweet [announcing publication of the PRF...
Nov 11 2016
So, the big question I have is this. If this were true, and pervasive,...
Oct 21 2016
To better treat pain, we require an understanding of the molecular...
Jul 26 2016
The new work reported by Rebecca Seal and colleagues indeed represents a...
Jul 11 2016
In my opinion the first line of the sixth paragraph in Part 2 is key in...
Jun 07 2016
Pain in infancy can have lifelong effects. In rodents, tissue injury in a...
May 29 2016
An interesting article which concludes that relief of pain by itself is...
May 16 2016
While several studies have previously demonstrated a role for the...
Mar 28 2016
Migraine is the third most common disease on Earth and the eighth most...
Mar 07 2016
By: PRF Team
Editor's Note: The work, described above, from Cobi Heijnen and...
Feb 01 2016
By: PRF Team
UPDATE: NEOMED has received approval from Health Canada to begin a phase...
Jan 27 2016
I tend to agree with comments from both of the above commenters. A large...
Q & A
Jan 26 2016
The debate is still ongoing. After the criticisms by Davis et al. on...
Jan 13 2016
An elegant paper by Xu et al. reports a potential new strategy to treat...
Dec 23 2015
Among the three main sodium channel alpha subunits present in nociceptors...

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Research Resources

Information for the new researcher or veteran in the field, Pain 101 is our growing collection of topical articles on important issues in pain research. Check out our articles on modeling pain in lower organisms, the role of glia in chronic pain, and transcranial magnetic stimulation. Our Pain Genes Resource will have the most up-to-date information on the genetics of pain sensitivity, risk of chronic pain and response to analgesics, presented in a format that makes it easy to keep current. We're in the process of pulling together data on the first  53 genes—you can help this resource grow by submitting new genes and studies. Stay tuned for more resources to come, including our Drug Pipeline database.