The April 17 webinar with speaker Andrew Charles is now available for viewing. Access the presentation and panel discussion below.
Charles, of the University of California, Los Angeles (UCLA) School of Medicine, US, gave a talk on current directions in the study of migraine pathophysiology and treatment, and how concepts about migraine may relate to other pain disorders. Following the talk, a distinguished panel discussed important issues raised by Charles' presentation. The discussion featured:
- Andrew Russo, University of Iowa, Iowa City, US
- Robert Shapiro, University of Vermont College of Medicine, Burlington, US
- Greg Dussor, University of Texas at Dallas, US (moderator)
Watch the webinar recording below
Here is Charles' abstract of his talk:
Basic concepts regarding migraine pathophysiology are evolving rapidly. Previously considered primarily as a vascular pain disorder, migraine is now more accurately considered as a genetically mediated brain disorder. The focus on migraine as an exclusively trigeminal nerve disorder is also changing with an understanding that input from the upper cervical nerves may play an important role. It is also now clear that hours before a migraine headache begins, a variety of symptoms, including sensory sensitivity, may occur and are correlated with changes in brain activity that can be visualized with functional imaging. These studies indicate that central sensitization in migraine is a primary phenomenon, rather than a secondary event produced exclusively by peripheral nociceptive input. These shifting paradigms in migraine science are opening up new possible avenues for acute and preventive therapies. We will discuss some of these therapies. It may also be useful to consider other episodic and chronic pain disorders in the context of these advances in the understanding of migraine.
Want some related reading? See the recent papers and a PRF news story under Related Content in the right column of this page.
“Paradigm Shifts in Migraine Science: New Opportunities for Therapy and Implications for Other Pain Disorders” is the eighth in a series of PRF webinars supported by the Mayday Fund. See previous PRF webinars.