Editors' note: The January 14 webinar with speaker Ted Price is now available for viewing. Access the presentation and panel discussion below.
In a January 14 webinar, presenter Ted Price, University of Arizona, US, gave a talk titled Targeting Translation Control Mechanisms to Ease Pain.
Following the talk, a distinguished panel discussed important issues raised by Price's presentation.
The panel featured:
- Ellen Niederberger, Pharmazentrum Frankfurt/ZAFES, Institut für Klinische Pharmakologie, Klinikum der Goethe-Universität Frankfurt, Germany
- Ilona Obara, Durham University, School of Medicine, Pharmacy and Health, Stockton-on-Tees, UK
- Ru-Rong Ji, Duke University Medical Center, Durham, North Carolina, US (moderator)
Watch the webinar recording below
Please share your thoughts on the webinar by posting a comment below.
Here is Price's abstract of his talk:
Control of gene expression at the level of translation is important for homeostasis and plasticity in most cells. Changes in gene expression are thought to underlie many plasticity mechanisms driving chronic pain disorders but the mechanisms governing these changes are still poorly understood. In the nervous system, activity-dependent control of translation affords neurons the ability to control gene expression in temporal and spatial dimensions. Activity-dependent control of translation in neurons is largely mediated by signaling pathways that are modulated by the mechanistic target of rapamycin complex 1 (mTORC1) signaling hub and mitogen-activated protein kinases such as extracellular signal-related kinase (ERK). Work in my lab has focused on how injury to the peripheral nervous system (PNS) alters translation regulation activity and how this level of gene expression control may contribute to the development and maintenance of chronic pain disorders. This line of investigation has led to several novel therapeutic avenues and molecular mechanisms including: 1) adenosine monophosphate-activated protein kinase (AMPK), which is a key endogenous negative regulator of both the mTORC1 and ERK pathways and 2) phosphorylation of eukaryotic translation initiation factor 4E (eIF4E), which is controlled by ERK signaling. In this webinar, I will give an overview of current views on how these targets and mechanisms provide novel insight into potential causes of chronic pain and how these mechanisms might be manipulated pharmacologically to create therapeutics with the potential for disease modification in chronic pain disorders.
Want some background reading? See the recent papers and related PRF news story under Related Content in the right column of this page. (Editors' note: Two very recent papers discussed during the webinar—Comprehensive RNA-Seq expression analysis of sensory ganglia with a focus on ion channels and GPCRs in trigeminal ganglia, and Opioid receptor-triggered spinal mTORC1 activation contributes to morphine tolerance and hyperalgesia—have been added to the bottom of the Related Content list).
“Targeting Translation Control Mechanisms to Ease Pain” is the sixth in a series of PRF webinars supported by the Mayday Fund. See previous PRF webinars.