Editors' note: The September 12th webinar with speaker Jon Levine is now available for viewing. Access the presentation and panel discussion below.
In a recent review in Pain, Jon Levine, University of California, San Francisco, wrote:
“The molecular/genetic era has seen the discovery of a staggering number of molecules implicated in pain mechanisms. This has stimulated pharmaceutical and biotechnology companies to invest billions of dollars to develop drugs that enhance or inhibit the function of many of these molecules. Unfortunately this effort has provided a remarkably small return on this investment. Inevitably, transformative progress in this field will require a better understanding of the functional links among the ever-growing ranks of ‘pain molecules,’ as well as their links with an even larger number of molecules with which they interact. Importantly, all of these molecules exist side-by-side, within a functional unit, the cell, and its adjacent matrix of extracellular molecules. To paraphrase a recent editorial in Science magazine, although we live in the Golden age of Genetics, the fundamental unit of biology is still arguably the cell, and the cell is the critical structural and functional setting in which the function of pain-related molecules must be understood.” (Reichling, Green, and Levine, 2013).
In a September 12 webinar entitled Toward a Cell Biology of Pain, Levine summarized concepts related to the nociceptor as a cell-biological unit that responds to a variety of extracellular inputs with a complex and highly organized interaction of signaling molecules.
Following the presentation, a distinguished panel discussed important issues raised by Levine's presentation. The discussion featured:
- James Campbell, Arcion Therapeutics and Johns Hopkins University, Baltimore, US
- Michael Gold, University of Pittsburgh, US
- William Mobley, University of California, San Diego, La Jolla, US
- Anne Louise Oaklander, Harvard Medical School and Massachusetts General Hospital, Boston, US, and PRF science advisor
- Stephen McMahon, King’s College London, UK, and PRF science advisor (moderator)
A recording of the webinar is available below.
Listen to the webinar.
“Toward a Cell Biology of Pain” is the third in a series of PRF webinars supported by the Mayday Fund. See previous PRF webinars.